Pharmacy to Dose: The Critical Care Podcast

Part 3 Critical Care Medication March Madness Bracket Downloadable bracket and more available here: https://pharmacytodose.com/2020/03/15/2020-critical-care-medication-march-madness-bracket-and-info/   03:01 – Final Four analysis with Matt Rubertus, PharmD, BCCCP 09:11 – Final Four analysis with Josiah Smith, PharmD, BCCCP 17:35 – Final Four analysis with Brian Gilbert, PharmD, BCPS, BCCCP 29:18 – Final Four analysis with Melanie Smith, PharmD, BCPS, BCCCP   Email: PharmacyToDose@Gmail.com Social Media: @PharmacyToDose Website: PharmacyToDose.Com Learn more about your ad choices. Visit megaphone.fm/adchoices

Part 2 Critical Care Medication March Madness Bracket  Downloadable bracket and more available here: https://pharmacytodose.com/2020/03/15/2020-critical-care-medication-march-madness-bracket-and-info/  00:50 – Introduction; 03:23 – Potpourri region analysis with Brian Gilbert, PharmD, BCPS, BCCCP; 43:43 – PAD region analysis with Melanie Smith, PharmD, BCPS, BCCCP  Email: PharmacyToDose@Gmail.com Social Media: @PharmacyToDose Website: PharmacyToDose.Com Learn more about your ad choices. Visit megaphone.fm/adchoices

Part 1: Critical Care Medication March Madness Bracket  Downloadable bracket and more available here: https://pharmacytodose.com/2020/03/15/2020-critical-care-medication-march-madness-bracket-and-info/ 00:58 – Bracket announcement, background, rules, and how you can participate!; 10:15 – Cardiac region analysis with Matt Rubertus, PharmD, BCCCP; 40:37 – Infectious Diseases region analysis with Josiah Smith, PharmD, BCCCP PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Immunotherapy Toxicity in the ICU Special Guest: Heather May, PharmD, FCCM, BCPS, BCCCP  Show Notes: https://pharmacytodose.files.wordpress.com/2020/03/immunotherapy-toxicity-in-the-icu-show-notes.pdf Show References: https://pharmacytodose.files.wordpress.com/2020/03/immunotherapy-references.pdf 00:52 – Show updates!; 10:50 – Immune system primer; 13:30 – How does CART therapy work?; 16:35 – CART Side effects that lead to the ICU; 17:40 – When does CRS occur and how acute is the presentation?; 20:50 – CRS risk factors; 23:26 – Biomarkers for CRS identification; 25:25 – CRS treatment; 32:30 – CART neurotoxicity; 37:00 – Mechanism of ICANS; 38:00 – ICANS risk factors; 39:30 – ICANS treatment; 42:45 – Where do patients go post-CART?; 47:15 – Examples of immune checkpoint inhibitors; 49:27 – ICI mechanism of action; 51:05 – Immune-related adverse events (irAEs); 55:20 – Which irAEs grades will present to the hospital/ICU?; 57:30 – When do irAEs occur?; 59:28 – irAEs treatment; 64:55 – Downside to treating irAEs?; 68:22 – Do irAEs mean the treatment is working?; 73:12 – Take-home points for immunotherapy toxicity PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

2020 SCCM Congress Recap Special Guest and Official Conference Correspondent: Anthony Hawkins, PharmD, BCCCP Anthony and I recap the 2020 SCCM Congress discussing everything from the convention center, research presentations, educational sessions, receptions, things we would change, and much more! This episode was recorded live in Orlando, FL. Show references: https://pharmacytodose.files.wordpress.com/2020/02/2020-sccm-congress-references.pdf PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com   Learn more about your ad choices. Visit megaphone.fm/adchoices

Acute Kidney Injury (AKI) Special Guest: Erin Barreto, PharmD, MSc, BCPS, BCCCP, FCCM Show Notes: https://pharmacytodose.files.wordpress.com/2020/02/aki-show-notes.pdf Show References: https://pharmacytodose.files.wordpress.com/2020/02/aki-references.pdf 1:10 – Show updates!; 9:15 – Define and classify AKI; 14:45 – Subspecifying the type of AKI; 18:22 – Prevalence of AKI in the ICU; 20:45 – Identification of high-risk patients; 24:43 – Preferred risk prediction tools; 26:12 – Ideal kidney biomarker; 28:28 – Ideal v. current biomarkers; 32:13 – Structural biomarkers; 39:40 – AKI prevention; 44:08 – Kidney/drug dosing equations; 53:49 – Equations in AKI/renal recovery; 56:43 – Cystatin C; 72:19 – What if you don’t use novel biomarkers?; 75:33 – Favorite calculator for AKI clinical risk predictor tool; 77:43 – AKI potpourri; 85:05 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Life After the ICU: A Personal Experience Special Guest: G. Morgan Jones, PharmD, BCCCP, FCCM Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/life-after-the-icu-show-notes.pdf Morgan details his incredible journey after a personal experience with PICS and PICS-F. PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Post-Intensive Care Syndrome (PICS) Special Guest: Jimmi Hatton Kolpek, PharmD, BSPharm, FCCP, FCCM, FNAP Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/pics-show-notes.pdf Show References: https://pharmacytodose.files.wordpress.com/2020/01/pics-references.pdf 00:25 - #PharmacyToRead Update; 10:07 – Why Jimmi is interested in PICS; 12:36 – When did PICS become an ICU focus?; 13:56 – How did PICS get thrust into the spotlight?; 15:40 – Definition of PICS; 16:27 – When does PICS occur?; 19:38 – How common is PICS?; 21:30 – PICS risk factors; 25:35 – How long does PICS last and how does it affect recovery?; 28:55 – Role of peer support; 31:20 – PICS prevention; 38:17 – Medications that can treat/prevent PICS; 41:50 – When to seek help for PICS?; 44:25 – Process for patients being referred to ICU Recovery Clinic; 48:12 – Who makes up the team and what problems are addressed?; 51:18 – What PICS resources are available for patients/families?; 54:35 – Do we prepare patients for what happens after the ICU?; 56:58 – How can we improve?; 59:53 – Take-home points on PICS PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Extracorporeal Membrane Oxygenation (ECMO) Special Guest: Amy Dzierba, PharmD, FCCM, FCCP, BCCCP  Show Notes: https://pharmacytodose.files.wordpress.com/2020/01/ecmo-show-notes.pdf Show References: https://pharmacytodose.files.wordpress.com/2020/01/ecmo-references.pdf  00:25 - #PharmacyToRead Announcement!; 07:50 – Why is Amy interested in ECMO?; 11:48 – What is ECMO and when did we start using ECMO in the US?; 13:45 – ECLS v. ECMO; 15:52 – Why are we talking about ECMO today?; 19:40– What does ECMO do?; 21:05 – ECMO modalities; 22:59 – ECMO equipment; 27:30 – What should be tried before ECMO?; 30:56 – ECLS effect on PK/PD; 40:05 – Tips/tricks on ECMO anticoagulation, infection, and sedation protocols; 40:45 – Anticoagulation protocols; 47:30 – Infection protocols; 53:15 – Sedation protocols; 58:18 – ECMO complications; 60:40 – Tips when creating or modifying ECMO protocols; 63:27 – Future areas of ECMO research; 65:00 – Take-home points PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Acute Respiratory Distress Syndrome (ARDS) Special Guest: Andrea Sikora Newsome, PharmD, BCPS, BCCCP Show Notes: https://pharmacytodose.files.wordpress.com/2019/12/ards-show-notes.pdf Show References: https://pharmacytodose.files.wordpress.com/2019/12/ards-references.pdf 4:42 – #PharmacyToRead Book Club Announcement!; 7:24 – History of ARDS; 10:17 – Current ARDS definition; 11:25 – Criticisms to Berlin definition; 13:54 – ARDS Causes/Risk factors; 15:33 – Typical ARDS time course; 18:58 – ARDS treatment goals; 21:04 – Brief primer on mechanical ventilation; 30:50 – Prone positioning; 35:17 – NMBA for ARDS; 42:15 – Prone, paralyze, or both?; 43:34 – FACTT study and fluid stewardship in ARDS; 46:00 – Corticosteroids in ARDS; 49:45 – ARDS failed drugs; 53:55 – ECMO for severe ARDS; 58:25 – Future research areas; 60:10 – Role of PharmD in ARDS PharmacyToDose.Com @PharmacyToDose on Twitter/Instagram PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices