Pharmacy to Dose: The Critical Care Podcast

Trial of the Week: ATHOS-3 Angiotensin II for the Treatment of Vasodilatory ShockSpecial Guest: Dr. Ashish Khanna, MD, MS, FCCP, FCCM, FASADr. Ashish Khanna joins me to highlight the ATHOS-3 trial, where Dr. Khanna is the principal investigator and first author of the NEJM publication.We discuss the history of angiogensin II, research prior to ATHOS-3, highlight findings from the ATHOS-3 trial, writing for NEJM, experience leading a large prospective RCT in the critically ill, what research do we have since this landmark publication, and much more.Reference list: https://pharmacytodose.files.wordpress.com/2023/09/athos3-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Insidious Harm of Medication DiluentsSpecial Guest: Carolyn Magee Bell, PharmD, BCCCPCarolyn Bell joins me to discuss her first author research study, the Insidious Harm of Medication Diluents. We review what the perception around balanced fluids was in 2016, advice for prospective research, ultimate trial take-aways, things she would do different, bribing other Pharmacists, and much more.Reference list: https://pharmacytodose.files.wordpress.com/2023/08/medication-diluent-trial-of-week-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Aneurysmal Subarachnoid Hemorrhage (aSAH) Part IISpecial Guest: Casey May, PharmD, BCCCP, FNCS04:24 – Guideline overview09:15 – Blood pressure management22:03 – Nimodipine31:15 – Antifibrinolytics36:58 – Hyponatremia and adjunctive treatments46:20 – Seizure prophylaxis49:10 -- Cerebral vasospasm/DCI treatment52:46 -- Gaps in guidelines, future trials, ideas for future studies60:25 – Take-home points Reference List: https://pharmacytodose.files.wordpress.com/2023/08/asah-part-ii-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Tamiflu Dosing ReviewSpecial Guest: Melissa Thompson Bastin, PharmD, PhD, BCCCP, FCCMMelissa Thompson Bastin joins me to discuss her review on oseltamivir dosing in the critically ill. We give an overview of the H1N1 pandemic, treatment regimens we used in the past, findings from this review, present-day oseltamivir dosing, applying lessons learned from H1N1 pandemic to the COVID-19 pandemic, and much more. Reference list: https://pharmacytodose.files.wordpress.com/2023/08/tamiflu-dosing-trial-of-week-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Heart Failure with Preserved Ejection Fraction (HFpEF) and Guideline/Consensus Document WritingSpecial Guest: Dave Dixon, PharmD, FACC, FAHA, FCCP, FNLA, BCACP, CDCES, CLS02:57 – Experience and advice with guideline/consensus document writing 19:40 – HFpEF definition, complications, acute presentation, and HFpEF mimics36:17 – HFpEF GDMT treatment61:50 – Future directions and take-home pointsReference List: https://pharmacytodose.files.wordpress.com/2023/08/hfpef-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Topics discussed include ESICM guidelines and definition of ARDS, phenotypes and respiratory support, corticosteroids, NMBA and VV ECMO, prone positioning in ARDS, absence of corticosteroids in guidelines, and personalized treatment strategies based on sub-phenotypes and biomarker profiles.

Trial of the Week: CATSSpecial Guest: Scott Benken, PharmD, MHPE, BCPS-AQ Cardiology, FCCM, FCCPScott Benken joins me to discuss the upcoming 2023 Chicagoland Critical Care Conference before reviewing the 2007 CATS study which compares catecholamine vasopressors and inotropes in septic shock. We cover the history of septic shock treatment, review the study results, current guideline recommendations, and much more.2023 Chicagoland Critical Care Conference registration link:https://appserv7.admin.uillinois.edu/FormBuilderSurvey/Survey/uic_college_of_pharmacy/continuing_education/critical_care_2023/SurveyReference list: https://pharmacytodose.files.wordpress.com/2023/08/cats-trial-of-week-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Trial of the Week: Unpeeling the Banana BagSpecial Guests: Aaron Cook, PharmD, FCCP, FNCS, FKSHP, BCCCP, BCPSAlex Flannery, PharmD, PhD, FCCM, BCCCP, BCPSListen to Aaron and Alex go into the history of this famous article, discuss how this paper, and how they still feel the impact years after publication.Flannery AH, Adkins DA, Cook AM. Unpeeling the Evidence for the Banana Bag: Evidence-Based Recommendations for the Management of Alcohol-Associated Vitamin and Electrolyte Deficiencies in the ICU. Crit Care Med. 2016 Aug;44(8):1545-52. https://pubmed.ncbi.nlm.nih.gov/27002274/PharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Rapid Reaction: MERCYSpecial Guests: Erin McCreary, PharmD, BCPS, BCIDPJason Pogue, PharmD, BCPS, BCIDP11:00 – Background, study methodology, and results23:00 – MERCY deep-dive, discussion, and future considerationsMERCY: https://pubmed.ncbi.nlm.nih.gov/37326473/Reference List: https://pharmacytodose.files.wordpress.com/2023/08/mercy-rapid-reaction-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices

Literature Review SeriesMay 2023Special Guest: Kelly Oldziej, PharmD05:00 – Featured Articles36:20 – Cardiology47:20 – Infectious Diseases51:00 – Emergency Medicine59:22 – PharmD66:15 – Grab BagReference List: https://pharmacytodose.files.wordpress.com/2023/07/may-lrs-2023-references.pdfPharmacyToDose.Com @PharmacyToDose PharmacyToDose@Gmail.com Learn more about your ad choices. Visit megaphone.fm/adchoices