The Life Scientific

Professor Hugh Montgomery is an intensive care physician and researcher at University College Hospital in London. His work has taken him to the Himalayas, where he and colleagues were studying the effect of oxygen uptake at high altitude. The findings were surprising and have implications for patients in intensive care. Jim al-Khalili talks to Hugh Montgomery about the gene for fitness and how mountaineers have influenced intensive care medicine.

Jim al-Khalili talks to the next chief scientific advisor to the government, Sir Mark Walport about how he thinks science can save the UK economy; how he plans to ensure that scientific evidence is taken seriously by an arts-dominated civil service and why he believes scientific research should be made available to everyone, free of charge. Sir Mark, who started his Life Scientific studying immune responses, has spent the last ten years in charge of one of the largest funders of medical research in the world, the Wellcome Trust. Many love his robust, straight-talking style: others find him uncompromising. He hopes to tackle environmental change and many of the problems associated with our ageing population, as well as changing Whitehall's attitude to science. It's hard to predict what other issues he may have to deal with, but even without an unexpected crisis, many anticipate that his forthcoming time in government will be nothing if not eventful.

Jim Al-Khalili meets Sunetra Gupta, a scientist and novelist. As a Professor of Theoretical Epidemiology she studies infectious diseases such as flu and malaria and explains how a mathematical equation can be as beautiful as a Keats poem.

Professor David Nutt was sacked in 2009 as the government's chief drugs adviser after criticising its decision to reclassify cannabis. He is a psychiatrist and one of the country's leading experts on the effects of drugs on the brain. His latest research is investigating how psilocybin, the active ingredient in magic mushrooms, could be used to treat depression. He talks to Jim about his passion for science and his disputes with government over drug policy.

Andrea Sella is a science showman, whose theatrical demonstrations of chemistry are filling theatres up and down the country. But as Professor of Materials and Inorganic Chemistry, Jim Al-Khalili asks him if he would rather be known for his research into rare metals than for his whizz bang displays.

Richard Dawkins' first book on evolutionary biology "The Selfish Gene" was published to much acclaim and some controversy in 1976. In this interview with Jim Al-Khalili, Professor Dawkins discusses his enthusiasm for the science that inspired the book and how he popularised the idea of the immortal gene. Using the source material from scientists such as Bill Hamilton, Robert Trivers and John Maynard Smith, he presented a gene's eye view of the world. He's written many other books on evolutionary biology, such as "The Extended Phenotype" "Unweaving the Rainbow" and "The Ancestors Tale". In 2006 he published a polemic which he describes as "a gentlemanly attack on religion", "The God Delusion". Jim asks what he hoped to achieve by writing the book and finds out why he would rather be known for his science than his atheism.

A world in which planes are silent may sound like a pipe dream; but University of Cambridge engineer, Dame Ann Dowling, and her team proved it is possible to build an aircraft that barely makes any noise. A brilliant mathematician and a keen pilot, Ann now heads of one of the largest engineering departments in Europe. Her design for a silent aircraft could improve the quality of life for millions of people living near airports worldwide: so does she mind that it never got off the ground? Jim talks to Ann Dowling about mathematics, engines and how she always wanted to do something useful. Producer: Anna Buckley.

For fifteen years, Martin Siegert has dreamt about Lake Ellsworth, a hidden lake buried beneath the Antarctic ice that's been cut off from the rest of the world for millions of years. Having studied data from airborne radar surveys, Martin knew the lake must exist and was determined to find out more. Finally, this winter, a team of British scientists led by Martin will drill through three kilometres of ice to unlock the secrets of this hidden lake. Can life exist in such a cold, dark and isolated place? And if so what form will it take? Martin describes working in Antarctica as being like an episode of Mash and explains why, unlike so many Antarctic scientists, he prefers analysing data to having icy adventures.

Jim Al-Khalili talks to botanist, Pat Wolseley about her obsession with lichen and the environmental secrets it holds. This humble and ancient organism contains a wealth of information about the quality of air we breathe. Certain species thrive on road traffic pollution: others prefer acid rain. And, for the last five years, thousands of people throughout the UK have been gathering scientific data on different lichen populations in their local area and using it to monitor air pollution.

Professor Steve Jones is a geneticist who says he lives life in the slow lane, studying snails. His work shows how animals adapt to the environment they live in. He is also a prolific writer of science books who wrote his first book, "The Language of the Genes" as a response to unsuccessful grant applications.