One of the tools scientists have used in autism research has been lab mice, genetically engineered to display similar behavioural characteristics as some humans with autism. But the value of those experiments, has become the subject of fierce debate amongst neuroscientists.It's also that debate that gets at the heart of what we do and don't understand about autism: Should we be trying to "cure" it by identifying its genetic causes? How? What exactly would that look like in practice? Where should we be focusing our research efforts, and why? As you might imagine, none of those answers are easy, or without contention...GUEST: Celia Ford, PhD, neuroscience; Future Perfect fellow at Vox We love feedback at The Big Story, as well as suggestions for future episodes. You can find us:Through email at hello@thebigstorypodcast.ca Or @thebigstoryfpn on Twitter

Ira Wells, a Toronto-based journalist for The Walrus, dives into the intriguing world of consumer rage in Canada. He discusses how everyday frustrations—like the price of a beloved sandwich—reflect a broader affordability crisis. Despite reports of improving economic indicators, Canadians feel more anger than relief. Wells explores the historical roots of this rage and how political parties are harnessing it. He questions what it means for future governments if affordability doesn’t improve and highlights the emotional toll inflation takes on people’s lives.

Daniel Otis, a freelance journalist specializing in UFOs, delves into Canada’s renewed focus on unexplained aerial phenomena. He discusses the Sky Canada Project, the first official UFO study in nearly 30 years, and the growing public interest in UFOs worldwide. The conversation highlights international collaboration, particularly within the Five Eyes alliance, and the urgency behind improving UFO reporting systems. Otis also examines recent sightings and the need for transparency in understanding these mysterious encounters.

Emily Durham, a Toronto-based career coach and host of the Straight Shooter Recruiter podcast, dives into the current Canadian job market. She discusses the recent creation of 47,000 jobs amidst rising living costs and declining labor force participation. Emily emphasizes the critical role of networking for job seekers and provides strategies for navigating negotiations for promotions and raises. The conversation highlights both optimism for gradual recovery and the reality of ongoing challenges, especially in sectors facing layoffs.

Brennan Doherty, a Toronto-based writer for The Local, dives into the realities of park encampments. He discusses the intertwining crises of housing, opioids, and the pandemic, shedding light on the often misunderstood individuals living in these camps. Through personal stories from residents like David Sessichelli, he illustrates their resilience amidst harsh conditions. Doherty challenges perceptions, advocating for empathy and a human rights approach to managing encampments while revealing the complexities of their choices and needs.

Shannon Waters, a B.C. politics and environment reporter at The Narwhal, dives into the contentious world of salmon farming in British Columbia. She discusses the environmental damage caused by open-net farms and the mounting pressure for reform from Indigenous communities and environmental advocates. Waters explores the logistical and economic challenges of transitioning to sustainable practices while considering the role of upcoming elections in shaping future policies. The fate of the salmon farming industry teeters between tradition and the urgent need for sustainability.

Glen McGregor, a Parliament Hill reporter for City News, dives into the increasing unrest within the Liberal Party surrounding Justin Trudeau's leadership. He discusses the mounting pressure from Liberal MPs calling for Trudeau's resignation and the formal letter they've drafted. The conversation explores the implications of by-election losses, the internal conflict during closed caucus meetings, and how a leader can be challenged. With potential future contenders in the mix, McGregor highlights the precarious state of party unity and the uncertain months ahead for Trudeau.

Aaron Rupar, a political commentator and creator of Public Notice, dives into the final weeks of the US election. He discusses Donald Trump's unconventional rally tactics, including a peculiar tribute to golfer Arnold Palmer. Rupar also examines Kamala Harris's strategy of highlighting Trump's controversies in her speeches. The pitfalls of polling data are explored, stressing the importance of grassroots campaigning. Finally, he highlights the impact of innovative campaigning through podcasts, especially in reaching non-traditional voter demographics.

Nicole Myers, an Associate Professor in Sociology at Queen's University, dives deep into Canada's complicated bail reform debate. She discusses the public outcry over crimes committed by those on bail and the political tensions this stirs. The conversation highlights the historical context of bail practices, ethical dilemmas in the legal system, and the impact of policies like Bill C-75. Myers emphasizes the need for a balanced approach that prioritizes both community safety and the rights of individuals, particularly within marginalized groups.

Laura Palmer, host of Island Crime, returns to discuss the tragic conclusion of Amber Manthorne's case. She shares the emotional turmoil faced by Amber's family as they sought answers. The podcast delves into police updates from a recent press conference and the investigative efforts that captivated the public's attention. Palmer also reflects on engaging with media and law enforcement during the investigation, showcasing the delicate balance between hope and heartbreak in the search for truth.