Inside the ICE House

Enveda Biosciences is using AI to decode nature’s vast chemical library and transform it into breakthrough medicines. Founded in 2019 by Viswa Colluru, the company is advancing first-in-class therapies like ENV-294 while cutting the time and cost of drug discovery. Colluru joins Inside the ICE House to share how Enveda is reimagining the playbook for modern medicine and building a healthier future for patients worldwide.

Nimbus Therapeutics is transforming drug discovery with computational chemistry and AI to design small molecules that precisely target disease. CEO Abbas Kazimi, who took the helm in March, is driving a “fail fast” approach that balances discipline with innovation. He joins Inside the ICE House to share how Nimbus is scaling its pipeline and shaping the future of precision medicine.

Michael Reinking, Senior Market Strategist for the NYSE, recaps a choppy week driven by tariff uncertainty, tech earnings misses, and focus on the upcoming jobs report. He notes August ended strong for small and mid-caps, but September’s seasonal weakness and rising global yields remain risks. Labor data showed slower hiring and AI-linked layoffs, though productivity gains offered a bright spot. Reinking flags the jobs report, expected Fed rate cuts, and inflation data as key drivers ahead.

AI is revolutionizing pharmaceuticals, moving from a side tool to a core driver of many aspects of the industry. Eli Lilly is leading the way, appointing Thomas Fuchs as its first Chief AI Officer to integrate AI across its pipeline. A NASA and Mount Sinai veteran, Fuchs is turning Lilly’s data into a competitive edge. He joins Inside the ICE House to share how Lilly is building the AI-powered medicine company of the future.

Alex Zweber, Portfolio Manager and Strategist at Parametric under Morgan Stanley Investment Management, joins Bilal Little, Director of Exchange Traded Products at the NYSE, to share his journey from derivatives trading to leading Parametrics' liquid alternatives team. He discusses the explosive growth of ETFs for income, protection, and growth, and how Parametric is bringing decades of institutional expertise into the ETF wrapper. 

The future of mental health is being transformed, moving beyond trial-and-error treatments to science-driven precision. Breakthroughs in neuroscience, AI, and precision medicine are mapping the brain’s unique biological signatures, creating pathways for personalized care. Alto Neuroscience is at the forefront, using brain biomarkers and AI to match patients with the right therapies—fast. Founded in 2019 by Dr. Amit Etkin, the company is rewriting the rules of mental health treatment. He goes Inside the ICE house to explain how Alto is turning guesswork into guided science and offering hope where it once felt out of reach.

In August, Inside the ICE House aired five new episodes, four traditional Inside the ICE House episodes, and one episode that kicked off a new, monthly series. Episode 480: Elanco CEO Jeff Simmons on Protecting Our Pets & Advancing Animal Health Episode 481: Edwards Lifesciences CEO Bernard Zovighian on Engineering Hope & Pioneering Purpose August Markets in Focus: Inside the ICE House x Opening Bell Daily Episode 482: Houlihan Lokey CEO Scott Adelson on Markets, M&A, and Building a Global Powerhouse Episode 483: W&T Offshore CEO Tracy Krohn on Steering Oil and Gas Exploration Through Industry Transformation

Michael Reinking, Senior Market Strategist for the NYSE, recaps a busy week following Fed Chair Powell’s dovish Jackson Hole remarks, which fueled a market rally and left the door open for a September rate cut. He highlights political drama around Fed independence, the U.S. taking stakes in Intel and MP Materials, and Nvidia’s strong earnings that lifted the AI sector. Reinking notes the S&P 500 hitting record highs with solid August gains, while warning that September brings labor data, inflation reports, and Fed policy decisions into sharper focus.

Artificial intelligence is reshaping industries by unlocking insights hidden within massive amounts of unstructured data. With powerful tools like vector databases and enterprise platforms, AI is driving breakthroughs across healthcare, finance, and entertainment. Pinecone founder Edo Liberty and HumanX founder Stefan Weitz have been at the forefront of this transformation. They join the Inside the ICE House podcast for breakfast on the balcony above the NYSE trading floor to share their journeys, explore the problems they’re solving, and discuss how AI is accelerating innovation and redefining the future.

The offshore oil and gas industry fuels progress by unlocking hidden energy reserves deep beneath the ocean’s surface. With advanced technology, it thrives in some of the world’s harshest environments to power industries, transportation, and daily life. W&T Offshore has been a leader in this space for more than four decades. Tracy Krohn, who founded the company in 1983 and still leads it to this day, goes Inside the ICE House to discuss W&T Offshore’s journey, its focus on efficiency, sustainability, and safety, and the future of offshore energy.