The HemOnc Pulse

In this episode of "The HemOnc Pulse," Dr. Goodman, an Associate Professor of Medicine at the University of California San Diego, joins Chadi Nabhan, MD, MBA, FACP, to discuss Castleman Disease. Dr. Goodman explains why the rare disease is often mismanaged, how each subtype is diagnosed and treated, and how it's comparable to hematologic cancers like lymphoma or myeloma.

Discussing the role of measurable residual disease in ALL treatment, advancements in TKIs for Ph+ ALL, medication-based treatments for high-risk patients, innovative strategies for Ph- leukemia patients, and the importance of achieving MRD negativity in leukemia therapy.

In this podcast, Drs. Dahiya and Spiegel discuss the FDA's 'Black Box' warning on CAR-T therapies for blood cancer patients. They explore the risks of secondary malignancies post-treatment and the impact of shifting CAR-T therapies to frontline treatments. The speakers stress the importance of informed consent, patient counseling, and evaluating the benefit-risk ratio in oncology treatments.

In this season's fourth episode of "The HemOnc Pulse," Catherine Coombs, MD, an Associate Professor in the Division of Hematology/Oncology at the University of California, Irvine, School of Medicine, highlights recent studies in clonal hematopoiesis of indeterminate potential (CHIP) presented at the 65th American Society of Hematology Meeting & Exposition. Dr. Coombs discusses research on reversing the adverse effects of CHIP, particularly its association with atherosclerotic cardiovascular disease, using interventions such as selective nuclear export inhibitors. She also illustrates another study that looks at the prevalence of CHIP in patients undergoing autologous hematopoietic stem cell transplant in lymphoma, which showed an increased risk of cardiovascular disease and lower survival rates.  

Discussion on the risks of secondary malignancies from CAR-T therapy, challenges of attributing lymphomas to CAR-T, exploration of insertional mutagenesis impact, concerns about myeloid neoplasms, and unique aspects of filter cell CAR-T therapy.

Dr. Aditi Shastri, Assistant Professor of Medicine at Montefiore Einstein Comprehensive Cancer Center, discusses TP53-mutated MDS, treatment options, risk stratification tools, emerging drugs like IMETEL stat and sabatolimab, and the decision-making process of observing versus intervening in patients with MDS.

The first episode of The HemOnc Pulse of the new year features an in-depth discussion by the leading researchers of the Hodgkin Lymphoma International Study for Individual Care (HoLISTIC) consortium. Principal investigators Susan Parsons, MD, MRP; and Andrew Evans, DO, MBA, MSc; are joined by Matthew Maurer, DMSc; to share the story behind harmonizing the world's Hodgkin lymphoma data, and what the effort means for both clinicians and patients.

Dr. Saad Usmani, Chief of the Myeloma Service at the Memorial Sloan Kettering Cancer Center, discusses the evolution in myeloma treatment and highlights the Perseus and IsKia trials. The podcast also covers advancements in achieving MRD negativity, personalized therapy for translocation 1114 myeloma, autologous stem cell transplant, maintenance therapy, and mechanisms of resistance to BCMA and GPRC 5D directed therapies in myeloma.

Sangeetha Venugopal, MD, of the University of Miami Sylvester Comprehensive Cancer Center, offers her thoughts on the investigational drug KER-050 in lower-risk myelodysplastic syndromes (MDS), the COMMANDS trial, and if she believes MDS is a distinct disease. She also highlights the latest research in MDS at the 65th American Society of Hematology Annual Meeting and Exposition.

In this episode of The HemOnc Pulse, Jerald Radich, MD, of the Fred Hutchinson Cancer Center, joins Chadi Nabhan, MD, MBA, FACP, to discuss various abstracts on acute myeloid leukemia (AML) presented at the 2023 American Society of Hematology (ASH) Annual Meeting & Exposition. The conversation centered around menin inhibitors for the treatment of AML, the effect of measurable residual disease-positivity on transplantation outcomes, and whether age plays a role in transplantation.