Feeling down from time to time is normal, but how can you tell when sadness is something more – like major depressive disorder? We spoke with Jessi Gold, MD, MS, the first chief wellness officer of the University of Tennessee system and bestselling author of How Do You Feel?, to unpack the complexities of depression. She breaks down the differences between temporary low mood and clinical depression, the role of genetics and medical conditions, and how daily stressors can contribute. We also dive into treatment options -- from therapy to medication -- and the importance of recognizing when it’s time to seek help.

Stress often gets a bad rap, but did you know some stress is not just helpful—it’s essential for a longer, healthier life? We spoke with Sharon Bergquist, MD, physician, research scientist, and author of The Stress Paradox: Why You Need Stress to Live Longer, Healthier, and Happier, about the science behind beneficial stress. She explains how short bursts of the right kind of stress can strengthen the body, sharpen the mind, and even boost longevity. Tune in to discover how to harness stress as a powerful tool for better health.

Every year on March 30th, World Bipolar Day shines a light on bipolar disorder, a condition often misunderstood. But what exactly is bipolar disorder, and how does it differ from unipolar depression? We spoke with Holly A. Swartz, MD, professor of psychiatry and president of the International Society for Bipolar Disorders, to break it all down. She explains the hallmark signs of mania and hypomania, how stressors can trigger episodes, and the latest treatment options, including therapy and medication. Plus, we explore the powerful impact of stable daily rhythms in managing mood and fostering long-term well-being. Resources: ISBD.org IPSRT.org

While some pain is normal and a necessary signal for our bodies, there is also pain that can be persistent and chronic. What is the difference between acute and chronic pain? And why do our brains sometimes amplify discomfort? We spoke with Daniel J. Clauw, MD, director of the Chronic Pain and Fatigue Research Center at the University of Michigan, about the complexities of pain management, how widespread and long-lasting pain is often rooted in the central nervous system, and treatments that go beyond just targeting muscles or joints. From physical therapy to acupuncture and mind-body techniques, we explore a range of strategies to help restore function and improve quality of life. 

Endometriosis affects an estimated 1 in 10 women, yet it remains underdiagnosed and misunderstood. How can you know if you have endometriosis? Why is it often missed? And what treatments—both surgical and medical—can provide relief? We spoke with Lora Shahine, MD, a double board-certified reproductive endocrinologist and OBGYN at Pacific North West Fertility, to break down its complexities – why symptoms vary, why it’s tough to detect, and how it impacts fertility. We also explored cutting-edge approaches in fertility care, emphasizing the importance of listening to patients. If you're experiencing symptoms, know that you have the right to advocate for yourself and seek the care you deserve.

Migraine isn't just a bad headache – it’s a complex neurological condition that can leave you sidelined for days. What are certain triggers for migraine? What are the treatment options? We spoke with Cynthia E. Armand, MD, associate professor of neurology at Montefiore Medical Center, who helps us break down what makes migraine different from headaches, the certain triggers that can set off an attack, and how tracking symptoms can be the key to managing them. Plus, we dive into treatment options, from over-the-counter meds to cutting-edge neuromodulation devices. Tune in for expert insights on taking control of migraine and finding relief.

Genetic testing can be both illuminating and intimidating. What exactly is genetic testing, and who might benefit most? We spoke with Huma Q. Rana MD, MPH, Clinical Director of the Division of Cancer Genetics and Prevention at Dana-Farber Cancer Institute and assistant professor of medicine at Harvard Medical School, about the impacts of genetic insights, breaking down the process, addressing logistical hurdles, like gathering your family history, and the range of possible test outcomes positive and what each might mean for your health and the health of your loved ones.

Generational trauma is the psychological and physiological effects that trauma can pass down through generations of families. But is generational trauma a life sentence, or can it be overcome? In this episode, we explore its impact on mental health with James Longman – journalist, ABC News chief international correspondent, and author of The Inherited Mind: A Story of Family, Hope, and the Genetics of Mental Illness. He shares insights from his research, his fight against stigma, and ways to support loved ones facing mental illness.

Multiple myeloma is a type of blood cancer that affects plasma cells in the bone marrow. And it most commonly impacts older adults, with higher prevalence among men and African Americans. What are the symptoms and signs that are often subtle or overlooked, leading to delays in diagnosis? What treatment options are available for those diagnosed? In this episode spoke with Jens Hillengass, MD, PhD, chief of the Myeloma and Amyloidosis Service and vice chair of research of the Department of Medicine at Roswell Park Cancer Institute about the importance of early detection, healthy lifestyle strategies, and recent advances in research that offer hope. We then sat down with Jacqueline Henry, BSN, RN, nurse manager for the lymphoma and myeloma department at Roswell Park, about what quality of life looks like for patients, treatment goals, and how to find hope after diagnosis.

Anorexia nervosa is a serious and complex mental health disorder marked by a distorted body image and an intense fear of weight gain. Often misunderstood, anorexia isn't about food or vanity – it stems from biological, psychological, and social factors and can affect anyone. What are the warning signs? And how can recovery be supported? We spoke with Kamryn Eddy, PhD, co-director of the Eating Disorders Clinical and Research Program at Massachusetts General Hospital and associate professor of psychology at Harvard Medical School, about how to recognize the signs of anorexia, supporting loved ones, emerging treatments options, and the crucial role of hope in recovery.