Phaedra Ellis-Lamkins, CEO and co-founder of Promise, revolutionizes welfare access using data and technology. Topics include applying for welfare, bail reform, and creating an ideal welfare system with technology. They explore AI's potential, addressing bias in tech design, and black maternal healthcare inequity. The podcast also discusses creating accessible technology, avoiding AI bias, and the importance of integrity and fitness in the next generation.

Contemporary artist Sarah Sze joins the podcast to discuss the relationship between art and technology. They explore the impact of AI on the intrinsic value of objects and whether AI democratizes art. Sarah also reacts to AI-generated art inspired by her work and how AI can enhance an artist’s work. The conversation delves into the intersection of physical and digital art and the role of technology in transforming art.

Science fiction author Kim Stanley Robinson joins the podcast to speculate about how we might evolve as a civilization. They discuss how he builds his science fiction worlds, the shifting pace of human acceleration, and how AI may change how humans organize themselves in the future.

Peter Lee, AI expert and Corporate Vice President of Research and Incubations at Microsoft, discusses the potential of AI in healthcare and demonstrates GPT-4's ability to provide a second opinion. They also explore the challenges of regulating AI while encouraging innovation and the importance of building effective technology around AI.

Reid Hoffman interviews CEO Jeff Berman about AI critics, adaptable strategic plans, superintelligence, GPT-4 capabilities, AI's potential in healthcare, generating different accents and languages, the decision not to sign an open letter on AI threats, and the importance of prioritizing humans in AI.

Cancer physician and author, Siddhartha Mukherjee, discusses the potential of AI in healthcare, the risks of incorporating AI into medicine, and the emergence of a new human. The podcast also explores the ethical implications of genetic and cellular technologies and the future of humanity's self-evolution.

Former Secretary of State Condoleezza Rice discusses the future of war and geopolitics in relation to artificial intelligence (AI). Topics include global collaboration in the AI space, legislating around AI for safety and innovation, the role of AI in foreign affairs and diplomacy, and building global governance around AI. The podcast also explores the complexities of global issues, the potential positive and negative effects of AI in war and defense, the Russo-Georgian War and the role of the US, US-China relations in the age of AI, and the importance of talent, being human, and progress with technology.

Anne-Marie Slaughter, CEO of New America, talks about the care economy and how technology can make humans whole. Topics include caring for elders, the childcare crisis, AI shifting the care economy, and the changing concept of human beings. They also discuss reorganizing businesses and governments for a better future.

Marques Brownlee, a self-taught YouTube creator, discusses how AI enhances his work and lowers barriers for creators. They talk about the arcs of technological progress, the power of electric vehicles, and what makes good technology.

Possible Season 2 explores the potential impact of AI on human creativity in media production. The hosts discuss the lineup of guests, including a popular YouTuber and a renowned science fiction writer. They mention using AI tools to explore big questions.