Comedians explore the early insane years of San Quentin prison, discuss the benefits of ketamine therapy, uncover the CIA's plan to overthrow the government of Iran, delve into manipulation and propaganda, compare inciting violence tactics to those of Trump and Putin, have a conversation with a ghost, witness chaos and confusion during a revolution, and provide updates on upcoming comedy shows.

Dave Anthony and Gareth Reynolds host political commentator and journalist, Sam Sacks. They discuss topics like royal dentistry in Sweden, unusual anatomy leading to surgical mishaps, lost stories in their hometown, a cheap beer mishap, a daring escape after a depot explosion, the ban on the Charleston dance, bizarre practices to stop cholera in China, Miss Gertrude's remarkable swim across the English Channel, and mistreatment and mistaken identity in camps.

Comedians discuss Iran's exploitation, Shah Reza's modernization efforts, racial classifications in America, and British interference. They also have a light-hearted conversation about death, describe an outrageous character, and share stand-up comedy show updates.

Hosts and guest comedian discuss newspaper articles from history, including Bigfoot tracks, dangerous objects, and crucifixes in schools. They also share humorous stories about receiving fines and tickets, and debate the use of a Whipping post for juvenile delinquency.

Chicago Soup Plot, struggling actor, mispronunciations, anarchy in the kitchen, investigation and discovery, press conference with hotel owner, investigation into anarchist bombing, the manhunt for the 'Super Anarchist', controversy and arrests surrounding food poisoning, the story of Gene Crohn's identity, immigration, and advocacy

The hosts discuss their recent intense text message exchange and their experience with different mattresses. They delve into the founding of San Quentin Prison, including the challenges faced, women inmates and living conditions, controversial plans for the prison, discrimination against Chinese people, racial dynamics and labor, and corruption and mismanagement at the prison.

Comedian and podcaster Sovereign Syre joins the hosts to discuss topics such as disfigured wives in the 1800s, researching historical narratives, a lumberyard fire and yellow fever epidemic, an ex-constable's embezzlement, disliking oysters and eating crickets, and a comical thief chase.

Comedians Gareth Reynolds and Dave Anthony discuss the enigmatic life of Alfred Packer with guest Adam Cayton Holland. They delve into Packer's upbringing, military service, hardships faced during a journey, gruesome discoveries, strange behavior, and sudden financial success. The chapter also touches on Packer's arrest, media attention, and his appearance during that time.

The hosts and guest discuss recording challenges and upcoming comedy specials. They mock bizarre incidents involving ducks and tanks. They ponder extreme decisions to escape unhappy marriages. They discuss alimony, mysterious coffee incidents, and a Lord warning against war. They debate the impact of postmarks on valuable stamps. They explore racial dynamics in a man's affection for Boise. They sarcastically discuss someone considering army enlistment. They analyze gender-specific physical features and the disappearance of hats. They question absurd stories about elephants and a girl with sticky lips. They discuss a man who lived with a bullet in his heart.

Comedians Gareth Reynolds and Dave Anthony explore John Murray Spear and his controversial life and beliefs. They discuss his unique apprenticeship experiences, the creation of the controversial Hangman game, his involvement in spiritualism, his mission to build a robot baby god, and his excavation project in search of a lost race of humans.