First Opinion Podcast

The Supreme Court's decision to overturn Roe v. Wade opened the door to allow states to ban or severely restrict abortion. But as biotech CEO Aoife Brennan and her colleagues are coming to realize, it will also affect how — and perhaps where — clinical trials are conducted. This week on the "First Opinion Podcast," Brennan, of Synlogic, talks about how the Supreme Court's ruling is forcing people involved in clinical research to rethink something as simple as pregnancy tests, which had once been taken for granted, and plan for the possibility that research sponsors and study sites will be required to share pregnancy and outcome data with state officials.

Polio has exploded back into Americans' consciousness after being out of the spotlight in the U.S. for half a century or so: In late summer, it paralyzed an adult in New York state, and the poliovirus has been detected in New York City's wastewater. This week on the "First Opinion Podcast," doctors Sallie Permar and Jay Varma make the case that pediatricians are the frontline for fending off this "old foe," but they need help.

Christopher Hartnick never expected his work as a doctor to intersect with political discussions about abortion and the right of pregnant people to make choices about their own bodies. Yet as a pediatric ear, nose, and throat physician who specializes in treating babies and children who have difficulty breathing, he's had up-close looks at how prospective parents make life-or-death decisions over the course of a pregnancy. This week, Hartnick discusses a risky procedure performed at birth for which parents must choose, at multiple stages, whether to prioritize the mother's life or the child's.

During his long career as a pediatric oncologist and cancer researcher, William Woods thought highly of the FDA's work evaluating and approving new cancer drugs. But his opinion of the agency changed when he was diagnosed with amyotrophic lateral sclerosis, or ALS, a progressive disease that damages nerves in the brain and spinal cord. This week on the "First Opinion Podcast," Woods talks about living with ALS, and watching what he sees as the glacial pace of approving an experimental ALS drug called AMX0035.

The number of children who become orphans because of Covid-19 rises each week: over 10.5 million children around the world have lost a parent or other caregiver living in the home, a staggering and heart-breaking figure. For comparison, it took 10 years years to create as many orphans as Covid-19 created in just two years.  Seth Flaxman and Susan Hillis have been tracking this grim statistic as part of their work with Global Reference Group on Children Affected by Covid-19. These losses can reverberate for years. This week, Flaxman and Hillis discuss the trials of children who have lost parents during the pandemic, and what can be done to help keep them safe and healthy.

For two decades, nurses have been considered the most trustworthy professionals in the country, above physicians. Yet the rigid hierarchy within hospitals and health systems places physicians at the top, creating a fraught power dynamic and a double standard when it comes to discipline. This week, nurses and educators Michelle Collins and Cherie Burke discuss this double standard as it relates to the recent cases of a former nurse and another former physician.

When Covid-19 began tearing across the U.S. in March 2020, Alex Goldstein started posting on Twitter the pictures and stories of people who had died from the disease.  Over two years later, as the U.S. marks the grim milestone of 1 million people dead from Covid-19, Goldstein is still at it. The account, @FacesOfCovid, has now memorialized more than 7,000 people.

Sickness can beget debt, which can then turn around and beget more sickness. That's the all-too-unfortunate cycle for people across the country who find themselves with overwhelming medical debt, the most common reason a debt collector might come after someone, with 1 in 5 households going into debt to pay for medical care. This week, Michelle Proser addresses ways to prevent medical debt and offers potential stopgaps that could help people get out of debt and into necessary, supportive health care environments.

Clinicians walk a tightrope when trying to help their patients with chronic pain. They want to be able to ease a patient's suffering with medication, but must be mindful of the risks of addiction. There are some non-medication treatments for pain, but they're often hard to access or not covered by insurance.  Finding the balance can be challenging and emotionally taxing. And in the wake of the opioid crisis, many clinicians tend to err on the side of caution and under-treat pain. This week, two physicians discuss how to treat chronic pain adequately and ethically.

The roll out of a new mental health crisis line for the entire U.S., is scheduled to happen on July 16 — the blink of an eye in bureaucratic time. People in mental health crises or their family members will soon be able to dial 988, instead of 911 or the harder-to-remember 800-273-8255, the number for the National Suicide Prevention Lifeline. The thinking is that calls to 988 will route people to the care they need instead of to law enforcement or emergency personnel with limited training in working with people in the midst of mental health crises. This week on the "First Opinion Podcast," Benjamin Miller probes at some more concerns: Who will be answering the calls? And does the system have the capacity to take care of callers right away?