Working Scientist

Deep brain stimulation (DBS) is an experimental treatment strategy which uses an implanted device to help patients with severe depression who have reached a point where no other treatment works.But despite her involvement in the DBS collaboration, which involves neuroscientists, neurosurgeons, electrophysiologists, engineers and computer scientists, neurologist Helen Mayberg does not see it as a long-term solution.“I hope I live long enough to see that people won't require a hole in their brain and a device implanted in this way,” she says . “I often have a nightmare with my tombstone that kind of reads like, what did she think she was doing?”Mayberg, director of the Nash Family Center for Advanced Circuit Therapeutics at the Icahn School of Medicine at Mount Sinai in New York City, introduces Brandy as a typical patient, who says of her condition; “It kind of holds me down, and it takes so much effort to do anything, or to experience anything, and there’s always that cost of, kind of reminds me of like scar tissue, like every time you stretch, it comes back and it holds you even tighter.”After receiving the treatment, Brandy describes the incremental changes that occurred: “Things got a little bit easier. And even in the smallest things, it got a little bit easier to brush your teeth, it got a little bit easier to get out of bed, it got a little bit easier to have hope. That just started a cascade of positive instead of the cascade of negative.”This is the tenth episode in Tales from the Synapse, a 12-part podcast series produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal.The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.

Thomas Hummel, who researches smell and taste disorders at the Technical University of Dresden in Germany, describes international efforts to help patients who have lost their sense of smell, perhaps as a result of COVID-19, head trauma, chronic rhinosinusitis, and neurodegenerative diseases.Hummel points to the development of cochlear implants to help patients with hearing loss. “There could be similar implants inside the nasal cavity connected to the olfactory bulb, eliciting a pattern that might make sense to the brain,” he says.Describing his career path, Hummel, who is also a medical doctor, says unlike some other clinical research areas, his is more heavily dependent on international collaborations. “When you work in cardiovascular diseases you just look around the corner and there’s somebody who works on cardiovascular disorders. In the sense of smell it is different. You look around the corner, and there’s nobody.” Hosted on Acast. See acast.com/privacy for more information.

In 2020 the forced isolation of pandemic-related lockdowns led many of us to attend virtual fitness classes and undertake home baking projects. Chantel Prat wondered why she wasn’t interested in taking part. “I couldn’t help but notice and be frustrated by the fact that my brain was responding to the pandemic in a way that seemed very different from the people around me,” she says.At the time Prat was writing her book The Neuroscience of You. Published in 2022, it explores how different brains make sense of the world. “I've always been interested in the relationship between the mind and the brain, at the level of the individual, not how do brains work in general,” she says.“Right now I feel like we’re living through a great social paradox,” she adds. “People are discussing the importance of having diverse minds and brains and decision-making spaces. But yet, we don’t seem to be getting any better at talking through our differences.”To illustrate her point, Prat, who is based at the University of Washington in Seattle, uses the 2015 online image of a dress which went viral and generated heated debates about its colour. Was it white and gold, or blue and black? “This is just a tiny example of how our experiences shape this world-building that we're doing, the way our brains create inferences and connect the dots, even for something as elementary as colour.” she says.She also recalls how, as a single mother aged 19, she first recognised that her baby daughter Jasmine perceived the world in ways that surprised her, based on lab experiments that she participated in. Hosted on Acast. See acast.com/privacy for more information.

A child neurologist treating Christin Godale’s epilepsy was so impressed with his young patient’s interest in the brain he gave her some of his textbooks to read during an extended stay in hospital.“He said I should consider a career in neuroscience. That moment really changed my life,” says Godale, who followed his advice and went on to research epilepsy for her PhD at the University of Cincinnati, Ohio.Godale describes how at one point she was experiencing up to 30 seizures a day and spent periods in a coma, severely curtailing her quality of life, childhood friendships, and graduate school experiences.“I’ve developed some habits to combat these cognitive impairments that I experience,” she says. “I find myself writing down everything that I’m learning in a lecture and hearing at a meeting.”When the pandemic struck in March 2020 and labs shut down, Godale embarked on patient advoacy work and science communication via the Society for Neuroscience’s early career policy ambassadors program.She lobbied Congress members to increase federal funding for neuroscience research, and in late 2021 decided on a career path that would involve her in both academia and industry, working for a seed fund focused on life science and digital companies in southwest Ohio.“During my graduate studies, I networked a lot. I encourage any early career researcher listening to this podcast to prioritize networking while you’re in graduate school,” she says. Hosted on Acast. See acast.com/privacy for more information.

In his 2022 book Zero to Birth, How the Human Brain is Built, developmental neurobiologist William Harris includes ice hockey analogies to describe how the body’s most complicated organ develops in the womb, drawing on a 40-year career studying fruit fly, salamander, frog and fish embryos.Harris, professor emeritus at Cambridge University, UK, played the sport growing up in Canada and is now a coach. “A coach will have tryouts and select the best players for different positions,” he says. “The brain does the same thing. Maybe two neurons try out for every position, one makes it that’s a little bit better at communicating, and the other one doesn’t, going through a process called apoptosis. The survivors have to last your whole life.”Harris highlights some differences between human and animal brains, (cerebral cortex size, for example, and how newborn babies are hard wired to understand and develop speech). Writing the book, he believes, made him respect human and animal brains even more. “Probably our brains are the most unique things about us. We have unique faces, but our brains are even more unique. You just can’t see them,” he says. Hosted on Acast. See acast.com/privacy for more information.

An applied goal of Pieter Roelfsema’s lab at the Netherlands Institute for Neuroscience in Amsterdam is to create a visual brain prosthesis aimed at people who have lost their sight.To help achieve this goal, the lab partners with both neurosurgeons and artificial intelligence researchers.“We are knowledgeable about how to put electrodes in the brain,” says Roelfsema, “but we collaborate with experts who know about how to make these electrodes so that they don't damage the brain tissue too much, also with people in artificial intelligence who can take camera images and translate them into brain stimulation patterns.“We also collaborate with neurosurgeons who can inform us how to really make this device and make it something that is going to be feasible for a neurosurgeon to really implant in the brain. That is definitely a very important goal for me, to bring this to a patient.”In episode five of Tales from the Synapse, a podcast series with a focus on brain science, Roelfsema describes how he handles requests from people who are pinning their hopes on being able to see again. “I have to explain this is not a clinically approved device,” he says.“Our ambition will be to go to humans in the next say, two years, or maybe a little bit later, but it’s still going to be research. There are all kinds of regulations, which are there for a good reason. And we have to show that we comply with all these regulations.”Tales from the Synapse is produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal. The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.

Gina Rippon was a paid-up member of the “male-female brain brigade” earlier in her career as a cognitive neuroscientist, but changed tack, she says, after discovering there was not a lot of sound research behind the well-established belief that male and female brains are biologically different.In the fourth episode of this 12-part podcast series Tales from the Synapse, Rippon explores the role of social conditioning to explain why boys and girls might respond differently to pink and blue objects, why girls aged nine describe maths “as a boy thing,” and why the same girls shun games that are aimed at children “who are really, really smart.”Rippon, Professor Emeritus of cognitive neuroimaging at Aston University in Birmingham, UK and author of the 2019 book The Gendered Brain , is also interested in why women continue to be under-represented in science even in countries that purport to be gender-equal.Her forthcoming second book investigates why girls and women on the autism spectrum have historically been overlooked. Viewing the condition through a gendered lens hampers our understanding of it, she argues.Tales of the Synapse, a podcast series with a focus on brain science, is produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal. The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.

After a mostly miserable childhood in the small Israeli village of Tel Aviv (his words), Ori Amir moved to the US, where he gained a PhD in cognitive neuroscience and launched a second career as a stand-up comedian.Amir is now a professor at Pomona College in Claremont, California, where he researches what happens in our neural networks when we are trying to be funny.His interest in this was triggered after realising there were around 20 studies examining brain activity when we are enjoying comedy, he says, but nothing about the creative process involved in being funny. Amir’s research also investigates attempts to use artificial intelligence to generate humour.“I’m afraid that if I make any jokes about artificial intelligence, I will get in trouble in the future. Artificial intelligence would cancel me. So I’m refraining from making any such jokes,” he tells his audience.Amir’s stand-up act also includes anecdotes about life as a PhD student. “It’s going to take seven years, the first five-and-a-half-years to work very hard on developing a silly accent,” he adds. “Then you do some original research and it all culminates in a dissertation defence in which you present your work in front of five important neuroscientists. And if you fail, they eat your brains.”This is the third episode of Tales from the Synapse, a 12-part podcast series with a focus on brain science, produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal.The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.

In the second episode of this 12-part podcast series, Tales from the Synapse, neuroscientist Anil Seth describes his research into consciousness, which he describes as “insurance against falling into a single, disciplinary hole.”Alongside neuroscientists, Seth’s research group at the University of Sussex in Brighton, UK, also includes string theorists, mathematicians and psychologists. The team also collaborates with academics in the arts and humanities.His 2021 book Being You: A New Science of Consciousness. begins by challenging the idea that consciousness is beyond the reach of science, and concludes with a look at consciousness in non-human animals, before asking if artificial intelligence will one day become both sentient and conscious.Seth’s own academic career path demonstrates the many disciplines with an interest in consciousness. He began studying physics but transitioned to psychology, computer science and artificial intelligence, the subject of his PhD at Sussex. He returned there to set up his neuroscience group after completing a postdoc at the The Neurosciences Institute in San Diego, California, from 2001-2006.He admits to an ongoing sense of wonder that that the self is experienced through brain activity, the “tofu-textured electrical wetware inside our skulls” with its “86 billion neurons and 1000 times more connections,” adding: “It seems like a miracle. But that’s the point of science, isn’t it, to preserve the wonder of a phenomenon, but to explain it too?"Tales from the Synapse is produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal. The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.

As a pharmacy student at the University of Wisconsin–Madison, Natasha Mason was struck by the high volume of patients who complained about opiates and antidepressants not working, but at the same time became more and more dependent on them.This observation triggered an interest in the behavioural effects of psychedelic drugs, which took her career in a psychopharmacological direction. She now researches the neural effects of cannabis, both when people are under the influence of the drug, and over the longer term, at Maastricht University in the Netherlands.Mason is also interested in the positive and negative effects of developing a tolerance to cannabis.“Recreational users tend to use cannabis for the relaxing or the euphoric effects. So here, tolerance can be seen as kind of a maladaptive thing. You have to use more of the drug to get the high that you want … This is where addiction dependence can come in,” she says.“But tolerance can be a good thing in regards to the clinical use of this drug. Individuals who are using cannabis for pain do not want the high, because this also comes with the impairment as well.”This 12-part Working Scientist podcast series, Tales from the Synapse, is produced in partnership with Nature Neuroscience and introduced by Jean Mary Zarate, a senior editor at the journal. The series features brain scientists from all over the world who talk about their career journeys, collaborations and the societal impact of their research. Hosted on Acast. See acast.com/privacy for more information.