Unseen Upside: Investments Beyond Their Returns

Travel to a Vermont dairy farm to see how AI is reshaping agriculture.Learn how data-driven tools are making farming more sustainable and productive, and how companies like Inari Seeds are engineering crops for a changing climate. This episode uncovers the future of food—where technology, tradition, and environmental stewardship meet.Guests include: Lucas Mann, Co-Founder and Managing Partner of Acre Venture Partners Catherine Feuillet, Chief Scientific Officer at Inari Richard Nelson, Farmer at Nelson Dairy Farm Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

Brandon White, co-founder of Axiom, discusses groundbreaking AI models that replace animal testing in drug development, making the process quicker and more humane. Stefan Strine from the Cleveland Clinic highlights their strategic investments in AI and quantum computing for healthcare innovation. Sunil Dhaliwal of Amplify Partners shares insights on the rise of computational biologists and how they drive AI integration in biotech. Together, they explore the ethical implications and future potential of AI in transforming medicine and improving patient outcomes.

What happens when AI meets the earth’s natural heat?Join us as we explore how Fervo and global partners are harnessing AI to unlock geothermal energy’s potential—delivering clean, flexible power around the clock. From Houston to the Middle East, we examine the science, policy, and investment trends driving the energy transition, and how geothermal could help power the AI revolution itself.Guests include: Fahad Alajlan, President at King Abdullah Petroleum Studies and Research Center (KAPSARC) Josh Posamentier, Co-Founder and Managing Partner of Congruent Ventures Tim Latimer, Co-Founder and CEO of Fervo Energy Tom Mitchell, Partner at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

Discover how AI is breaking down barriers to education and tailoring learning experiences for students everywhere.From Duolingo’s global reach to the innovative use of AI in real classrooms at Miss Porter’s School in Connecticut, this episode explores how technology is expanding access, enhancing engagement, and equipping the next generation with essential skills—while ensuring integrity and safety remain at the forefront.Guests include: Luis von Ahn, CEO and Co-Founder of Duolingo Henry Ellenbogen, Chief Investment Officer at Durable Capital Partners Maureen Lamb, Latin teacher and the Language Department Chair at Miss Porter's School Dean Dimizas, Partner and Managing Director at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

Get ready—Season 6 of Unseen Upside launches October 21.This season, we’re taking you behind the scenes to explore how AI is transforming our world. From labs and classrooms to clinics and fields, we’ll follow the capital and uncover how AI is driving the next chapter of human progress.Tune in for episode one on your favorite podcast platform, Tuesday, October 21.

Once numbering in the tens of millions, the American bison was nearly driven to extinction by the early 1900s. But a coalition of conservationists, Native American communities, and private partners were determined to save the species.Join us for this mini episode of Unseen Upside: Investments Beyond Their Returns, as we share the remarkable story of the bison’s restoration alongside John Calvelli, Executive Vice President of Public Affairs at Wildlife Conservation Society.Stay tuned for Season 6 which explores the transformative impact of AI across industries—launching Tuesday, October 21. In the meantime, catch up on past episodes in our podcast feed!Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

Summer isn't over just yet--Unseen Upside is bringing you Part 2 of our summer reading list! Tune in as we share more book recommendations from investors and entrepreneurs on the leading edge of healthcare. Check the show notes for links to all the recommendations, and catch up on past episodes in our podcast feed. Stay tuned for Season 6—launching soon.Featured Recommendations: The Frozen River: A GMA Book Club Pick by Ariel Lawhon The Hard Thing About Hard Things: Building a Business When There Are No Easy Answers by by Ben Horowitz Zero to One: Notes on Startups, or How to Build the Future by Peter Thiel  Clayton M. Christensen’s Books Fifty Miles from Tomorrow by William L. Iggiagruk Hensley A Fortunate Man: The Story of a Country Doctor by John Berger  Guests Include: Theresa Hajer, Head of US Venture Capital Research at Cambridge Associates Alyssa Jaffe, Partner at Seven Wire Ventures Lucas Trout, Lecturer on Global Health and Social Medicine at Harvard Medical School Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

As summer heats up, Unseen Upside brings you a special two-part mini-episode packed with inspiration for your reading and listening list. From thought-provoking explorations of social justice and capitalism to the latest in women’s sports and business innovation, this short episode is your guide to what’s fueling the minds and spirits of those driving change in healthcare, housing, and beyond.Whether you’re looking for your next great read, a podcast to spark new ideas, or just want to know what’s on the radar of industry leaders, this episode has you covered. Check the show notes for links to all the recommendations, and stay tuned for part 2 of our guests' summer picks soon!Featured Recommendations: Weathering: The Extraordinary Stress of Ordinary Life in an Unjust Society by Dr. Arline T. Geronimus James (Pulitzer Prize Winner) by Percival Everett Outliers: The Story of Success by Malcolm Gladwell Just Mercy: A Story of Justice and Redemption by Bryan Stevenson A Brief History of Seven Killings (Booker Prize Winner): A Novel by Marlon James  Queens of the Court (The Women’s Hoops Show Podcast) Americana: A 400-Year History of American Capitalism by Bhu Srinivasan Acquired: Novo Nordisk (Ozempic), Season 14, Episode 1 Unseen Upside: Appetite for Change: The Obesity Epidemic Meets Biotech Guests Include: Chavon Sutton, Managing Director, Sustainable & Impact Investing at Cambridge Associates Lynne Chou O’Keefe, Founder and Managing Partner at Define Ventures Tim Ortez, Chief Financial Officer of the Weingart Foundation Margaret Anadu, Senior Partner at The Vistria Group Jasmine Richards, Head of Diverse Manager Research at Cambridge Associates Gunnar Esiason, Head of Patient Engagement at RAVen (RA Ventures) Dean Dimizas, Partner in the Private Client Practice at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm with 50+ years of institutional investing experience. We partner with private clients, endowments, foundations, pension plans, and corporations to design and manage custom portfolios focused on generating alpha and achieving investment objectives. Our services include outsourced CIO, non-discretionary portfolio management, staff extension, and alternative asset class mandates.

There’s a maternal health crisis in the United States, with high rates of maternal mortality, especially among marginalized communities. But what is being done to improve it? Through conversations with those on the front lines, we uncover the stark health inequities that exist in maternal healthcare and the developments created to tackle them. We also hear from mothers who have firsthand experience with Preeclampsia—a serious pregnancy complication and one of the many causes of maternal mortality— and one company on a quest to cure it.  Guests include: Scott Gottlieb, MD, Partner at New Enterprise Associates and Former FDA Commissioner Scott Johnson, MD, Chief Executive Officer and Co-Founder at Comanche Biopharma Jennell Lynch, Chief Executive Officer and Founder at Executive Doula Agency  Theresa Hajer, Head of US Venture Capital Research at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.

How will evolving digital technologies impact healthcare delivery, patient experience, and access to care?According to new venture-backed companies, they can advance health equity, democratize access, and empower individuals to take control of their health journey. Alongside industry pioneers and investors, we explore digital health advancements such as telemedicine, remote monitoring, and data-driven diagnostics that are all working to improve healthcare efficiencies.Join us as we uncover the potential of these technologies to improve healthcare outcomes for all.Guests include: Lynne Chou O'Keefe, Founder & Managing Partner at Define Ventures Siva Namasivayam, CEO & Co-Founder at Cohere Health Chavon Sutton, Senior Investment Director in the Sustainable & Impact Investing Research Group at Cambridge Associates Unseen Upside: Investments Beyond Their Returns is developed in partnership with PRX, an award-winning podcast media company.Cambridge Associates is a global investment firm that works with endowments, foundations, healthcare systems, pension plans, and private clients to implement and manage custom investment portfolios that aim to generate outperformance and maximize their impact on the world. Cambridge Associates delivers a range of portfolio management services, including outsourced CIO, non-discretionary portfolio management, staff extension, and asset class mandates.