Hot on the heels of her recent Tonight Show appearance, comedian Candice Thompson (@jokesbyCandice) joins Matt and Andy to talk about Punching Henry, the movie Matt is in with Henry Phillips, ASMR, Richard Simmons, anti-Brit racism, what zoo animals taste like, Neanderthals’ medication, mini-pigs and films about them, iCondoms, 3D printing medical supplies and pizzas, swimming pool pee and dog fMRIs.

Comedian and actor Johnny Pemberton (@johnnypemberton) of Son of Zorn joins Matt and Andy to discuss water shortage solutions and Indiegogo lies, pipe bombs, ulcerative colitis, money you can piss on, a better way to crowdsource, training bees to play with balls, chiropractic, more opinions on cats and toxo, saving polar ice and eating da poo-poo.

Comedian Kate Willett (@katewillett) joins Andy and Matt to talk about NASA's big exoplanet announcement and Episode 70 of our show discussing exoplanet research, the twin paradox, twin astronauts, fake Twitter accounts, a study showing that cats may not make you crazy, and a chiropractor's creative menstrual invention.

Comedians Ever Mainard (@evermainard) and Deborah Etta (@deborah_etta) join Andy and Matt to talk about scientific weirdos and Galois, starfish and STDs and regrowing dicks, finger regrowth, Matt’s awful ex, why whales jump, unethical kitten experiments, science fairs gone wrong, more blood and shit stuff, moon stuff and monkeys and dogs judging cooperation in humans. This episode is brought to you by Audible. For a free 30-day trial, visit audible.com/psp.

Danish comedian Simon Talbot (@simontalbot_) recently relocated to the US, and he joins Matt and Andy to talk about Andy's cold apartment, Jehovah's witnessing, Simon’s weird blood, our no-butthole ancestor, dinosaur protein, Danish traditions, time crystals, ask-a-sociopath, talking viruses and a possible way to reverse antibiotic resistance.

British comic James Acaster (@JamesAcaster) stopped by to talk with Matt and Andy about city rivalries, science marches, conga/flute/didgeridoo combos, Jerusalem Syndrome and Paris Syndrome, human/pig chimeras, cats possibly being as intelligent as dogs, Matt not knowing how big an otter is, giant otter fossils, slowing down light, a light speed sonic boom and James' band Luna Dott Raids the Bee Pigeon.

Podcaster Andrew Ti (@ANDREWTI) of the popular show (and blog) Yo, Is This Racist? joins Andy and Matt to talk about injecting frog neurotoxins in eyes, unethical self-experiments, the EPA vs. Trump, fake news inoculation, a free course on critical reasoning, poop stuff, mouse lasers, dumb psychopaths and who is, in fact, racist.

Comedy writer and improviser Laura Willcox (@Laura_Willcox) and comedian Andy Peters (@andy_peters) join Matt and Andy to talk about famous and not famous namesakes, failing low-level tests, sharks reproducing asexually, dud rockets, rhino shit as social media, cat marking and the parasites in it, a massive Venus wave, the truth about lemmings and other potentially dodgy kids' films, plus alchemy.

Actor/author Maggie Rowe (@ThisMaggieRowe) has written for Arrested Development and produced both Hollywood Hell House and Hollywood Purity Ball, and her new book Sin Bravely: A Memoir of Spiritual Disobedience chronicles her early experiences as a born-again Christian and her time spent in an Evangelical psychiatric facility. Maggie joins Matt and Andy to discuss entropy and evolution, false memory and sleep, synaesthesia and lightning strikes, icebergs and global warming, the antimatter story we didn’t cover, the origins of Stouffer's french bread pizza, and radio bursts from a galaxy billions of light years away.

British standup and sketch comic Steve Hall (@stevehallcomedy) happened to be stateside for the holidays, so he stopped by to talk with Matt and Andy about pamphlets and Thomas Paine, the passing of dark matter-discoverer Vera Rubin, ants using tiny sponges to carry honey, new evidence that suggests an iceberg didn't cause the Titanic to sink, why sustainable fishing might not be the best, molten underground rivers, Bill Gates and an effective Ebola vaccine, Dr. Jane Gregory's Cognitive Behave Yourself, inverted farting, Eric Cantona's goal, a pretend city for kids and First Kiss by Steve's sketch group We Are Klang.