Probably Science

Andy Wood, Matt Kirshen
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Feb 4, 2026 • 1h 8min

Episode 594 - David Huntsberger

Comedian David Huntsberger returns to the show to talk with Matt, Jesse and Andy about his podcast Intercepts, his new platform The Endless Abyss, the lost art of sketch comedy albums, the world's worst redaction, Redactle, how dogs build their vocabularies like toddlers, Stella the talking dog, dumb dogs, breed stereotypes, Bad Will Hunting, the worst logo and name in education, longevity in meat-eaters and the foresight of The Machine Stops.
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Jan 30, 2026 • 1h 10min

Episode 593 - Diya Basrai

Comedian/neuroscientist Diya Basrai (@diyabasrai) joins Jesse, Andy and Matt to talk about Moravec's Paradox, whether there's something meat-specific about intelligence, a less-pessimistic AI take, a tool-using cow, Diya's comedy special and his comedy/science live show Uncontrolled Variables.
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Jan 21, 2026 • 1h 10min

Episode 592 - Jon Stringer

Comedian Jon Stringer (@jonjstringer) joins Andy, Jesse and Matt to talk about living in a converted rural Kansas church, the intricacies of comedy competitions and cruise ship comedy, dry ice PVC soupcan launchers, the oldest known use of poison arrows, retail blowguns and their misuse, vibe-coding a band manager, why you should stop using hydrogen peroxide on cuts, sword canes and pendulous doorknockers.
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Jan 13, 2026 • 1h 15min

Episode 591 - Imaan Hadchiti

Comedian Imaan Hadchiti (@imaanfrankhadchiti) joins Jesse, Andy and Matt to talk about Rima syndrome, the movie Tiptoes, the passing of an art legend, sniffing farts to prevent Alzheimer's, what actually causes ice to be slippery, when physical aging really kicks in and making paralyzed rats walk again in a really creepy way.
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Jan 4, 2026 • 1h 13min

Episode 590 - Waen Shepherd

Comedian/actor/writer/composer Waen Shepherd (@waenshep) joins Andy, Jesse and Matt to talk about the new album from his alter ego Gary Le Strange, the biology of elves, the best chocolate chip cookie recipe, a runaway supermassive black hole, a lemon-shaped exoplanet and the music of Gary Wilson.
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Dec 28, 2025 • 1h 10min

Episode 589 - Chris Duffy

Comedian/host/author Chris Duffy (@chrisiduffy) returns to the show to talk with Jesse, Andy and Matt about his new book Humor Me: How Laughing More Can Make You Present, Creative, Connected, and Happy, his radio show/podcast You're The Expert, his TED podcast How To Be a Better Human, the unintentionally phallic Covid-era Terry Crews video Chris worked on with Matt and Andy, prescribing standup to improve mental health, training Swedish crows to pick up cigarette butts and a frozen worm revived after 46,000 years.
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Dec 16, 2025 • 1h 18min

Episode 588 - Buddy Fitzpatrick

Comedian Buddy Fitzpatrick (@buddycomic) joins Andy, Matt and Jesse to talk about Batman's effect on subway chivalry, the rooms of Madonna Inn, ladyfingers, manmade fire from 350,000 years earlier than previously thought, monogamy across the animal kingdom and an insane chain of rabies transmission via organ transplantation.
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Dec 9, 2025 • 1h 24min

Episode 587 - Adam Burke

Comedian Adam Burke (@atpburke) joins Andy, Jesse and Matt to talk about Adam's new comedy special Unamerican, debunking the Stanford Prison Experiment, classic '80s Arnold movies, Matt and Jesse performing together in Nashville, the preacher who shot an escaped lab monkey, AIs that believe themselves to be more rational than humans, 3D printing with a mosquito proboscis, Andy's upcoming orchestra shows and Matt's upcoming San Deigo standup show.
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Nov 28, 2025 • 1h 25min

Episode 586 - Ophira Eisenberg

Comedian/writer/NPR host Ophira Eisenberg (@ophirae) joins Andy, Jesse and Matt to talk about her podcast Parenting Is a Joke, her upcoming special produced by Lewis Black, the effect of venting on anger, a rage room show Andy worked on, why you should leave uncontacted tribes alone, the wombat-thief influencer and why you should speak up to seagulls.
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Nov 14, 2025 • 1h 12min

Episode 585 - Jeff Zenisek

Comedian Jess Zenisek (@jeffzenisek) joins Andy, Jesse and Matt to talk about tennis, homophobic sports stereotypes, Jesse's new ski persona, Mr. Wizard, Jeff's hair care regimen, a tiny tyrannosaur, a better rock-paper-scissors strategy, gray hair's relationship to cancer, the worst music to play during sex and the banger Parked By The Lake.

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