Comedian and physical therapist Laura Hayden (@LauraHaydenFun) joins Jesse, Andy and Matt to talk about her penile pictorial book What About Dick, a decrease in average body temperature, sciatica advice, the benefits of pooping before you exercise, Matt's upcoming Australia tour and Andy's upcoming Warsaw Poland Bros gigs.

Comedian Forrest Shaw (@forrestshaw) returns to the show to talk about stalking manatees with police helicopters, gambling addiction, his upcoming podcast I've Got a Problem, survival of the wittiest, a lost branch of humanity's family tree, Matt's upcoming comedy shows in Eureka and Medford and Andy's upcoming Warsaw Poland Bros shows in Santa Barbara and Los Olivos.

Comedian Matthew Broussard (@mondaypunday) returns to the show to chat with Jesse, Andy and Matt about Matthew's new special Hyperbolic, exaggerated accents, the CEO shooter, cyborg beetles, a quantum computing milestone, gray goo, online security in a post-quantum world, elliptic curves, conic sections, Fermat's Enigma and a super old bird mother.

Comedian Becky Braunstein (@beckyfromalaska) joins Andy, Jesse and Matt to talk about growing up Jewish in Alaska, eruv rules and topology, orcas bringing back the salmon hat fad, the dangers of squeezing limes in bright sunlight, and tiny vodka-propelled robots.

Comedian/writer/actress Laura Kightlinger (@KingKightlinger) joins Matt, Jesse and Andy to talk about spontaneous human combustion, Bourbon Room comedy shows in Hollywood, the story behind Andy's various bands,  the Uranus story we don't want to cover, how one atom can change a parrot's color, blurb machine Peter Travers, peacock spiders, a blue whale that's been leaking oil for 26 years and a flu strain that we've basically beaten. 

Screenwriter James Lamont joins Matt, Jesse and Andy to talk about writing the upcoming Paddington in Peru, alcohol detox champion hornets, Shatner's double SPATS, memory not being confined to the brain, Jesse getting checked in on by local kids and Matt's oath to take up arms for the United States.

Comedian Benny Blue (@bennyblueeyes) joins Jesse, Andy and Matt to talk about brat summer transitioning into the fall of civilization, Benny's new special Live From My Mother's Funeral, Benny and Andy's Blue Lake connection, Anarchist Cookbook adolescent shenanigans, why humans are the perfect size for speed, Matt and Andy's show with the 2022-iest name ever, the best mural ever painted and its painter, Norm MacDonald's sketch artist sketch, how an asteroid got ants into farming fungi, Jesse's love of 90-Day Fiancee, Matt's upcoming comedy shows and Andy's upcoming ska shows.

Comedian and former Probably Science cohost Brooks Wheelan (@brookswheelan) joins Jesse and Andy to talk about his new special Alive In Alaska, Tony Hinchcliffe entering the election arena, cats beating babies at word association, Don't Wake Daddy, snake talk just for Brooks, the Teddy Roosevelt biography The River of Doubt, Chuck Klosterman's The Nineties, the ever-changing landscape of standup and Andy's upcoming gigs with Warsaw Poland Bros.

Comedian Jeffrey Jay (@heyjeffreyjay) joins Matt, Jesse and Andy to discuss UnCertified Fresh, the Matt Walsh-iverse of awful movies, Earth gaining a second moon, the orbital path of that object, an octopus that punches fish to make them help it hunt and choceted EEG caps for cats.

DJ Qualls (@TheOnlyDJQualls) and Kelly Blackheart (@kellyblackheart) of the Locked & Probably Loaded podcast join Matt and Jesse to talk about DJ's upcoming movie Carved, Nashville dive bars, the Ark Encounter, the Ig Nobel prize for butt-breathing, extreme aging, re-creating Mars in a lab and resurrecting the woolly mammoth.