The Drug Science Podcast

Professor Badiani received his doctoral degree in Medicine and Surgery from Sapienza University of Rome and carried out post-doctoral research in Italy (CNR), Canada (CSBN), and USA (University of Michigan) to then return to Sapienza University Medical School as Assistant Professor in the Department of Pharmacology, progressing to the rank of Full Professor in 2008. At Sapienza he also served as Associate Chief Physician in the Drug Addiction unit of the University Hospital. Additionally, he has been President of the European Behavioural Pharmacology Society (EBPS) from 2011 to 2013. Professor Badiani conducts research in the field of drug addiction with the focus on the role of environmental factors in determining individual vulnerability to drug addiction in both humans and animals. In this episode of Drug Science podcast you’ll learn about the most recent research on the science of drug addiction from a leading expert in the field. Jane StewartDopamine Terry RobinsonCocaine AmphetamineDrug sensitization (reverse tolerance)PsychotomimetismPsychosisIncentive sensitization theory of addiction Kent C BerridgeMorphineHeroin Adrenal glandHuda AkilStriatumNucleus accumbensFrontal cortexOpiatePsychostimulant Naloxone precipitated withdrawal increases dopamine release in the dorsal striatum of opioid dependent menRussell’s Circumplex Models ★ Support this podcast ★

Professor Allan Young is a psychopharmacologist and the Director of the Centre for Affective Disorders in the Department of Psychological Medicine in the Institute of Psychiatry, Psychology and Neuroscience at King’s College London. Prof Young is the clinical academic lead in the Psychological Medicine and Integrated Care Clinical Academic Group in the South London and Maudsley NHS Trust where he is also a Consultant Psychiatrist and the head of the National Affective Disorders Tertiary Clinic.  Professor Young’s research interests focus on the cause and treatments for severe psychiatric illnesses, particularly mood disorders like depression. He has received research grant funding from the UK Medical Research Council, the Wellcome Trust, and numerous other respected funding agencies worldwide. He has published over 400 peer-reviewed publications and a number of books about psychopharmacology and affective disorders. According to the 2014 Thomson Reuters Highly Cited Researcher list, Professor Young was recently ranked as one of the world's leading scientific minds in the field of Psychiatry and Psychology. DepressionBipolar disorderMajor depressive episodeAnhedoniaICD-10DSM-5Atypical depressionImmuno-metabolic depressionSSRIRapid cycling bipolar disorderTricyclic antidepressantsMonoamine oxidase inhibitors (MAOIs)Dopamine receptor D2Cognitive Remediation TherapyInstitute of Psychiatry, Psychology & NeuroscienceCBTKetamineEsketamine: Ketamine nasal spray BioavailabilityPsilocybin: From Serendipity to Credibility?COMPASS Pathways ★ Support this podcast ★

Listen in to hear Robin’s valuable perspective on matters such as assisted death, private education and the difference between a debate and a conversation. The Demon-Haunted WorldThe Infinite Monkey CageAssisted dyingSection 28Peter Singer if…Frankie HowerdAmusing Ourselves to Death ★ Support this podcast ★

Coming from Canada, home to one of the most progressive drug addiction services in the world, Manisha was reporting for VICE News in their new documentary 'Beyond Fentanyl' which looks at how drugs like “benzos,” "dope” and “tranq” are ravaging North American communities and how U.S. policy affected the latest flood of synthetic street drugs. Tune in to this week’s episode for a VICE  journalist’s perspective on drug policies around the world.  OxycodoneHeroinFentanylBenzodiazepinesDowner and upper drugsDrug overdoseNoradrenalineLofexidineAwakn clinic“This Is Something That Changed My Life”: A Qualitative Study of Patients' Experiences in a Clinical Trial of Ketamine Treatment for Alcohol Use DisordersibogainePsilocybinAyahuascaDMTToad venom5-MeO-DMTSupervised injection sitesNaloxoneBristol drug testingThe LoopMephedroneMonkey dustBath Salts drugoxycontin crisisCannabisBeyond Fentanyl documentary  ★ Support this podcast ★

This week’s episode features Professor Bruce Alexander, a psychologist and professor emeritus from Vancouver, BC, Canada, author of two books about addiction: Peaceful Measures: Canada's Way Out of the War on Drugs and The Globalization of Addiction: A Study in Poverty of the Spirit. Professor Alexander conducted a series of experiments into drug addiction known as the Rat Park experiments. Which brought into light the true complexity of addiction and the influence of our environment on how we use drugs and how they affect us. Listen to this episode to find out why the “demon drug myth” is extremely out of date with the scientific world and what we can do to debunk it. Skin poppersHeroinMorphineDemon drug mythIan KershawRat parkHow permanent was Vietnam drug addiction ★ Support this podcast ★

This week’s episode features English television and radio presenter, and model Melanie Sykes.Melanie is an advocate for medical cannabis use for childhood epilepsy and other chronic conditions. In 2021 she became an Ambassador in Medcan Support - a non-profit community interest company who provide free resources and educational material on medical cannabis, the endocannabinoid system and the positive outcomes cannabis treatment has had on so many people throughout the UK. With her support, she helps fight the stigma and raises other issues which are preventing access to the natural medicine.Listen to this episode of the podcast to find out more about medical cannabis and also how an autism diagnosis at 51 can change your life!  Don’t ‘Talk to FRANK’ but do check out the Frank magazine -> The Frank Magazine CannabisAutismHarry ThompsonADHDNeurodivergenceMedcan supportThe Autistic Brain: Thinking Across the SpectrumThe Frank MagazineHempWeed the PeopleEpilepsyProject Twenty21William Broke O’Shaughnessy ★ Support this podcast ★

This week’s episode features yet another great speaker at the ESPD55 conference Mark Plotkin, an ethnobotanist, advocate for tropical forest conservation and the host of Plants of the Gods podcast. Following research at Harvard under Richard Evans Schultes and years of working in a close relationship with the native communities of Amazonia, Mark with his books, podcasts and talks educates the public about the wondrous world of plants, their history, medicinal and cultural significance. Accordingly, he advocates for saving tropical forests as entities inseparable from their indigenous cultures. His group Amazon Conservation Team focuses on helping the communities to survive within the modern world rather than subordinate to it. Tune in to the episode to find out how we can help these communities grow but also how wine, magic mushrooms and other substances might have influenced our own culture.The Plants of the GodsKary MullisThujone ESPD55Dennis McKennaStoned Ape HypothesisDrunken monkey hypothesisThe Ethnobotany of Wine as Medicine in the Ancient Mediterranean WorldRichard Evans SchultesScopolamineErik the redThe Shamans and Apprentices ProgramTales of a Shaman’s ApprenticeTimothy LearyAmazon Conservation Team Ethnographic mappingPeyoteAyahuascaMescalineRichard SpruceAlfred Russel WallaceDMTCocaCocaineCannabisKratomIbogaine ★ Support this podcast ★

Wade Davis is a Canadian cultural anthropologist, ethnobotanist, author, and photographer. Davis came to prominence with his 1985 best-selling book The Serpent and the Rainbow about the ‘zombies of Haiti’. He is professor of anthropology and the BC Leadership Chair in Cultures and Ecosystems at Risk at the University of British Columbia.Davis has published articles in Journal of Ethnopharmacology, Outside, National Geographic, Fortune, and Condé Nast Traveler. He is an Explorer-in-Residence at the National Geographic Society and had produced 18 documentary films. His work has largely focused on worldwide indigenous cultures, and has taken him to, among others, East Africa, Borneo, Nepal, Peru and Tibet.As a honorary citizen of Colombia, Wade Davis educates about the true culture of a country known mostly for its drug cartels and cocaine scandals. Listen to this week’s episode to find out about Colombia and its sacred plant - Coca, a stimulant milder than tea and with more nutritional benefits than all the plants we know of.  ESPD55.comLeaves of GrassGold Museum, BogotáKogi peopleMorphineOpiumOpioidsHow Coffee Fuelled RevolutionsCaffeinePenny universityDEA Drug SchedulingHallucinogensTimothy LearyManuel SantosCocaineCoca leavesCoca wine (Vin Mariani)Dennis McKenna Albert HoffmanPeyoteRichard Evans ShultesAlkaloidVolstead actAndrew Weil ★ Support this podcast ★

Dennis Jon McKenna is an American ethnopharmacologist, research pharmacognosist, lecturer and author. He received his doctorate in botanical sciences from the University of British Columbia and completed post-doctoral research fellowships in the National Institute of Mental Health and in the Department of Neurology at Stanford University School of Medicine. His research has included the pharmacology, botany, and chemistry of ayahuasca and oo-koo-hé, the subjects of his master's thesis. He has also conducted extensive fieldwork in the Peruvian, Colombian, and Brazilian Amazon. Having authored numerous scientific articles and books, McKenna’s work led to the development of natural products for Aveda Corporation as well as greater awareness of natural products and medicines. Additionally, together with his brother Terence McKenna and Jeremy Bigwood, he developed a technique for cultivating psilocybin mushrooms, and published what they had learned in a book Psilocybin - Magic Mushroom Grower’s Guide.With that immense experience and knowledge of psychedelics, Dennis McKenna is a founding board member and the director of ethnopharmacology at the Heffter Research Institute, A non-profit which investigates the potential medicinal uses of these substances.Tune in to this week’s episode to find out about the true significance of ethnopharmacology and a conference organised by Dennis that you’ll be able to stream online very soon!ETHNOPHARMACOLOGIC SEARCH FOR PSYCHOACTIVE DRUGSDennis McKennaESPD 50National Institute of Mental HealthAlexander ShulginAndrew WeilEthnopharmacologic Search for Psychoactive DrugsEthnopharmacologyCocaCody SwiftCOMPASS psilocybin trialPsilocybinESPD 55“Sea DMT” Tryptamine in Sea SpongesNew York Times DMT toad article How to Change your Mind by Michael PollanNational Institutes of Health (NIH)Poison arrow frogsBufoteninSerotonin receptorsAyahuascaAutoradiographyLSDSalvinorinKappa opioid receptorICCERS - The International Centre for Ethnobotanical Education, Research, and ServiceIbogaAyahuasca tourismMckenna’s missionDMT: The Spirit Molecule (documentary)ESPD55.comPsilocybin Pulse DosingMicrodosingOregon Drug DecriminalizationSet and settingSerotoninDopamineDefault mode networkRobin Carhart-Harris5-HT2a receptor ★ Support this podcast ★

This week we’re talking about ketamine with Professor Celia Morgan, a Professor of Psychopharmacology at the University of Exeter and the academic lead for Exeter Translational Addiction Partnership (ETAP) and Ketamine for Reduction of Alcoholic Relapse (KARE). Professor Morgan is interested in the effects of drugs and alcohol on the brain and behaviour. Her research focuses on examining both the benefits and side effects of recreational drugs on cognition, mental health and neurobiology. Through behavioural, neuroimaging studies and clinical trials, she has investigated the potentially therapeutic sides of controlled substances in clinical trials aimed at the treatment of addiction and in particularly looking at drugs such as ketamine and MDMA in combination with psychological therapies. Tune into this week's episode to find out all about ketamine and how cycling around squats in North London can be part of scientific research...  ★ Support this podcast ★