Tobacco and alcohol are the largest sources of preventable death in the world. Our current treatments are only 15% effective at best. However, psilocybin-assisted therapy has achieved an astonishing 80% success rate in clinical trials. Professor Matthew Johnson is paving the way for this new an innovative treatment to address one of the most damaging social burdens of modern society, drug addiction. It is important to note that Professor Johnson’s research is not looking at casual habitual smokers, but instead, long-term, treatment resistant tobacco users.  Matthew W. Johnson, Ph.D., Professor at Johns Hopkins, has worked with psychedelics since 2004. He published psychedelic safety guidelines in 2008, the first psychedelic treatment of tobacco addiction in 2014, and with colleagues published the largest study of psilocybin in cancer distress in 2016. His 2018 psilocybin review recommended Schedule IV upon medical approval. He is Principal Investigator on upcoming psilocybin studies treating opioid addiction and PTSD, and LSD research treating chronic pain. Matt and the Johns Hopkins Psychedelic Research Unit are examining the long-term behavioural changes resulting from a single psilocybin session and cognitive behavioural therapy. Johns Hopkins Psychedelic Research Unit Professor Matthew Johnson Smoking cessation study Smoking cessation research Roland Griffiths Episode Healthy normals research  Smoking cessation behaviours three months following acute insular damage from stroke IbogaineBreathwork for treating PTSD Twitter - @Drug_Researcher Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

This week, Professor Nutt speaks to journalist Johann Hari @johannhari101 about the ‘war on drugs’. It is now widely accepted that the ‘war on drugs’ has failed, with many people believing it can never succeed. Despite this, politicians from around the world continue to follow this mantra as an effective strategy to reduce drug-related harms. The reason why… politics. Currently, it is politically damaging to support the legalisation of drugs because public discourse has been led to believe that legalisation will cause anarchy and chaos. Contrarily, what we have now is a complete lack of control. Legally regulating the supply of drugs is the only way to bring order to this chaos. Johann Hari is the author of two New York Times best-selling books. His first, ‘Chasing the Scream: the First and Last Days of the War on Drugs’, is currently being adapted into a major Hollywood film by Oscar-winning director Lee Daniels, and into a non-fiction documentary series. His first TED talk, ‘Everything You Think You Know About Addiction is Wrong’, has been viewed more than 40 million times across all platforms. He has written over the past decade for some of the world’s leading newspapers and magazines, including the New York Times, the Los Angeles Times, the Guardian, the Spectator, Le Monde Diplomatique, the Melbourne Age, and Politico. He is a regular panellist on HBO’s Realtime With Bill Maher.Chasing the Scream Lost ConnectionsProfessor Nutt fired Portugal decriminalisation Bud OsbornSafe injection facilities Philip Owen – coffin Billie Holiday Strange Fruit Ruth DreifussNeil Woods episode Swiss experiment Crispin Blunt episode Harry Anslinger Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

The tables have been turned in this one-off special of the Drug Science podcast. In this episode, Professor David Nutt is interviewed by renowned singer-songwriter – Joss Stone. Professor Nutt is the Chair of the Drug Science Scientific Committee and currently the Edmund J Safra Professor of Neuropsychopharmacology and Head of the Neuropsychopharmacology Unit at Imperial College London. Professor Nutt has steered the psychedelic renaissance toward legitimate research in the UK enabling the next generation of researchers to expand our understanding of these substances. In this week’s episode, Professor Nutt is interviewed by singer-songwriter Joss Stone. Joss became a friend of the show after appearing in our first season of the podcast to talk about Medical Cannabis. Now she’s back to ask the Professor some burning questions about cannabis, psychedelics, SSRI’s, Adderall, addiction and pain. A Cuppa Happy podcastUnited Patients Alliance Medical cannabis slides  CannabisPrescribed CBD could help people quit cannabisTwenty21NICE guidelineHarry AnslingerMedical Psychedelics Working Group  Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

On July 14th 2020, the UK’s leading independent scientific body on drugs has launched the Drug Science Medical Psychedelics Working Group. Building off the success of the Medical Cannabis Working Group, the Medical Psychedelics Working Group is a consortium of Drug Science experts, leading academics, researchers and policy specialists, supported by industry partners. The group’s aim is to create a rational and enlightened approach to psychedelic research and clinical treatment. The group will explore innovation within the psychedelic space with a specific focus on how psychedelics can be integrated into primary and secondary healthcare. Evidence-based science, sharing data, and strong partnerships are keys to success for the psychedelic community. The purpose of this group is to break down the barriers of 50 years of medical censorship by creating a rational and enlightened approach to psychedelic research and clinical treatment, ensuring the UK is a world leader in psychedelic medicine.Jo Neill is Professor of Psychopharmacology at the University of Manchester (Division of Pharmacy & Optometry). She is Chair of the Medical Psychedelics Working Group for Drug Science and a committee member, a scientific advisor for Heroic Hearts UK and the Conservative Drug Policy Reform Group. She is co-founder of b-neuro, a University based Contract Research Organisation developing new treatments for mental illness through animal models. Jo is past President of the British Association for Psychopharmacology (President 2016-2018). She served on the Research Excellence Framework panel for Unit of Assessment 3 (Allied Health Professions, Dentistry, Nursing and Pharmacy) in 2014. Jo is working with Policy at Manchester to educate the public about the urgent need for drug law reform and suspension of Schedule 1 restrictions to enable research into the medicinal properties of currently illegal drugs. Medical Psychedelics Working Group B-Neuro Neil Woods episode Psilocybin for depression episode Veterans and psychedelics part 1 Veterans and psychedelics part 2Veterans and psychedelics part 3Psilocybin slides MDMA slides Judith Aldridge Fiona Measham James Morgan DMT episode Neil Woods MP letter Denver decriminalisation Oakland decriminalisation Psilocybin in The Telegraph Magic Medicine Film US Expanded Access Programme From Shock to Awe Anorexia trial at Imperial College Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

In this episode of the Drug Science podcast, Professor Nutt is joined by an old friend who he has known for 35 years. Professor Roland Griffiths is a researcher who has examined a wide range of psychotropic substances through the years. He has studied, the abuse potential of a number of different substances; caffeine dependence and withdrawal, and the relative prices people are willing to pay for access to common street drugs. Roland Griffiths, is a Professor in the Departments of Psychiatry and Neurosciences at the Johns Hopkins University School of Medicine, and founding Director of the Johns Hopkins Center on Psychedelic and Consciousness Research. His principal research focus in both clinical and preclinical laboratories has been on the behavioral and subjective effects of mood-altering drugs. He has conducted extensive research with sedative-hypnotics, caffeine, and novel mood-altering drugs. In 1999 he initiated a research program investigating the effects of the classic psychedelic psilocybin that includes studies in healthy volunteers, in beginning and long-term meditators, and in religious leaders. Therapeutic studies with psilocybin include treatment of psychological distress in cancer patients, treatment of cigarette smoking cessation, and psilocybin treatment of major depression. Other studies have examined the effects of salvinorin A, dextromethorphan, and ketamine which produce altered states of consciousness having some similarities to psilocybin. Drug interaction studies and brain imaging studies (fMRI and PET) are examining pharmacological and neural mechanisms of action. The Hopkins laboratory has also conducted a series of internet survey studies characterizing various psychedelic experiences including those associated with acute and enduring adverse effects, mystical-type effects, entity and God-encounter experiences, and alleged positive changes in mental health, including decreases in depression and anxiety, decreases in substance abuse, and reductions in death anxiety. Caffeine Psilocybin Benzodiazepines Psilocybin occasioning mystical-type experiences+14 month follow up Johns Hopkins Center for Psychedelic & Consciousness ResearchJournal of Psychopharmacology William James Religious Experience Psilocybin for religious clergy Matt Johnson tobacco addiction study Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

In this episode of the Drug Science podcast, Professor David Nutt is joined by two pharmacosexuality experts to discuss chemsex, drug fuelled sex parties and sexual psychonauts. From the peak sexual experience to sober sex, our relationship with sex and drugs is complicated but intrinsically personal. Find out who chooses to mix sex and drugs, the risks associated with doing so, and what pleasure this provides people who combine the two.Dr Alex Dymock (@alexdymock) is Lecturer in Law at Goldsmiths, University of London. Her research is concerned with the regulation of sexuality, sexual subcultures, pornography, criminal law, and the history of drugs and drug policy. She co-led the Wellcome Trust funded Pharmacosexuality project (@pharmacosex) from 2018-2019, which examined the relationship between drug use and sexuality.Dr Leah Moyle (@leah_moyle) is Lecturer in Criminology at Royal Holloway, University of London. Leah’s research focuses primarily on understanding illicit drug markets, cultures of drug use, and ‘non-commercial’ supply. She co-led the Wellcome Trust funded Pharmacosexuality project (@pharmacosex) from 2018-2019, which examined the relationship between drug use and sexuality. Project websiteArticle for Wellcome Trust with Dr Ben MechenGBH/GBLMDMAAlcoholVice documentary on chemsexBlueLightShulgin – MDMA for relationship workErowidStephen Port caseACMD call for reclassification of GHBReynhard Sinaga casePoppersTesto-junkieVylessi  Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

DMT is a drug that’s relatively novel in western neuropsychopharmacology. Not much research has been done on this substance to date and many intoxicants are unable to recount their psychedelic experience. For the first time, this substance is being studied in an fMRI and EEG to elucidate why and how this drug elucidates vivid dreams and near-death experiences. Chris Timmerman recently completed his PhD in neuropsychopharmacology at Imperial College London, investigating the effects of psychedelic drugs in the human brain with Robin Carhart-Harris and David Nutt. He is developing his research with a focus on the effects of psychedelics in consciousness and brain connectivity. Chris recently lead a study involving the effects of DMT in the human brain and experience, while also understanding its potential use for mental health conditions. Having gained a BSc in neuroscience, Dr Chloe Sakal went on to study medicine and gain membership with the Royal College of Psychiatrist. She has a keen interest in the psychopharmacology and the potential for the therapeutic use of psychedelic drugs in treating a wide range of psychiatric disorders. She is a study doctor for the UKs first MDMA-assisted psychotherapy trial looking at the safety and tolerability of its use in the treatment of alcoholism. She is an assistant-therapist on a phase two study looking at the treatment of psilocybin-assisted therapy for the treatment of depression. Alongside this, Chloe was a study participant in Chris Timmerman’s DMT research. DMT Brain imaging study (Coming soon) DMTAugusto PinochetMDMA alcoholismRick Strassman LSD brain imaging studies Life After Life – Raymond Moody5-MeO-DMTPsychiachixBecome a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

Crispin was elected MP for Reigate in 1997 having formerly served as an army officer. In Parliament, Crispin has served in the Shadow Cabinet with briefs including trade and energy and security and counter-terrorism. He has served as both Minister for Prisons and as Chairman of the Foreign Affairs Committee. He is currently the co-Chair of the All-Party Parliamentary Group on Drug Policy Reform. In January 2019, Crispin set up and launched the Conservative Drug Policy Reform Group (CDPRG) whose objective is to promote evidence-based drug policy reform on the centre right. He is currently the Group’s unremunerated Chair and Chief Executive Officer.Crispin takes a conservative look at the lack of regulation in the drugs market, questioning why the UK fails to tackle criminal gangs through prohibition, how the UK economy is damaged by turning a blind eye to the billions made in the cannabis industry and what can be done to win this war. Furthermore, Crispin Blunt and Professor Nutt discuss the racist beginnings of the ‘War on Drugs’ and how those sentiments have continued until present day. The killing of George Floyd antithesis’s the need to challenge this racist war through the Black Lives Matter movement. ---------------------------------***Free Drug Science event***Medical Psychedelic Working Group Event <<< register here <<<***From the best & brightest minds working in psychedelics***---------------------------------Jeff Smith Good Cop Bad War Drug Wars TransformCDPRGCDPRG report on the cannabis market Mike Barton PSA 2016 Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

From an early age, Mitch Schultz's curiosity of the unknown universe forged his path in storytelling. His work as a transmedia producer, UX designer, and educator explores the inherent connections among consciousness, nature, culture, and the evolving human mythology.The Documentary ‘From Shock to Awe’ asks, “how do we heal our deepest wounds?”. This film offers an intimate and raw look at the transformational journey of two combat veterans suffering from severe trauma as they abandon pharmaceuticals to seek relief through the mind-expanding world of psychedelics. Recent scientific research coupled with a psychedelic renaissance reveals that these substances can be used to heal PTSD (Post-Traumatic Stress Disorder) for individuals and their families. Beyond the personal stories, From Shock to Awe also raises fundamental questions about war, the pharmaceutical industry, and the US legal system.---------------------------------***Free Drug Science event***Medical Psychedelic Working Group Event <<< register here <<<***From the best & brightest minds working in psychedelics***---------------------------------Rick Strassman  DMT: The Spirit MoleculeFrom Shock to AweFlorida Church using AyahuascaGonzales v. O Centro Espírita Beneficente União do VegetalAyahuasca/DMTWhat is PTSD?Become a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★

War continues to hurt people long after the fighting has stopped. Veterans suffering from post-traumatic stress often self-medicate with alcohol or they are prescribed a cocktail of anti-depressants and opioids. This story is far too common for Nathan Pohl, A US veteran who served 2000 days of deployment in multiple combat zones. Nathan was not given the support he needed when he returned home, but luckily, he was introduced to the healing power of plant-based medicines before it was too late. Dr. Kate Pate is a neurophysiologist from a military family and has always been passionate about finding ways to help military service members and veterans. This passion, coupled with her interest in plant-based medicines and her journey to find ways to heal from her own traumas, led her to cross paths with Heroic Hearts Project. Kate joined HHP as the Director of Research in early 2019 and has been working closely with the team to investigate the ways in which ayahuasca can benefit veterans suffering from PTSD and other mental health issues, and how changes in the gut microbiome following ayahuasca consumption may be correlated with long-term behavioural changes. Dr. Pate has been conducting research for nearly 15 years in a variety of different areas.---------------------------------***Free Drug Science event***Medical Psychedelic Working Group Event <<< register here<<<***From the best & brightest minds working in psychedelics***---------------------------------Heroic HeartsAyahuascaEntheogenPsychedelic integrationMAPS MDMA trialsKetamine ClinicsDr Christopher LowryColorado DecriminalisationBecome a Drug Science Community Member: https://www.donate.drugscience.org.uk/Twitter: @ProfDavidNutt @Drug_ScienceA Fascinate Productions podcast for Drug Science ★ Support this podcast ★