Science Weekly

A first-of-its-kind non-hormonal drug to treat hot flushes has been approved in the US. Targeting connections in the brain that change during menopause, the drug, called fezolinetant, could provide relief for those who aren’t able to take hormonal replacement therapy. Madeleine Finlay speaks to endocrinologist and menopause specialist Prof Annice Mukherjee to find out what we know about the mechanism that causes hot flushes, how this new drug works, and what it might mean for those experiencing menopause in the future.. Help support our independent journalism at theguardian.com/sciencepod

More than 40 leading scientists have resigned en masse from the editorial board of a top science journal in protest at what they describe as the ‘greed’ of the publisher. Ian Sample speaks to correspondent Hannah Devlin about the remarkably lucrative business of scientific publishing, hears from Prof Chris Chambers about what was behind the recent mass resignation, and finds out why researchers are demanding change. Help support our independent journalism at theguardian.com/sciencepod

The pioneering IVF procedure known as mitochondrial donation therapy (MDT) could prevent children from being born with devastating mitochondrial diseases. Madeleine Finlay speaks to Prof Darren Griffin, an expert in genetic diseases and reproduction, about how MDT works, the ethical considerations attached, and what techniques like it could mean for the future of reproduction. Help support our independent journalism at theguardian.com/sciencepod

Psychedelic drugs have long been been used for their mind-altering effects. Now, they are making their way into western medicine as a treatment for mental health disorders. From July, psychiatrists in Australia will be able to prescribe MDMA for post-traumatic stress disorder, making it the first country in the world to recognise psychedelics as medicines. The US could soon follow, with plans for the US Food and Drug Administration to be asked for approval to treat PTSD with MDMA this year. Ian Sample speaks to correspondent Hannah Devlin about how the science behind psychedelic therapy has progressed, and hears from Prof Celia Morgan about what treatment is actually like, what we know about the risks and what’s left to learn. Help support our independent journalism at theguardian.com/sciencepod

For the first time, researchers have found a way to non-invasively translate a person’s thoughts into text. Using fMRI scans and an AI-based decoder trained on a precursor to ChatGPT, the system can reconstruct brain activity to interpret the gist of a story someone is listening to, watching or even just imagining telling. Ian Sample speaks to one of the team behind the breakthrough, the neuroscientist Dr Alex Huth, to find out how it works, where they hope to use it, and whether our mental privacy could soon be at risk. Help support our independent journalism at theguardian.com/sciencepod

As the planet warms, and intense heatwaves become the norm, our urban environments need a radical rethink to keep them habitable. So what do we want the cities of the future to look like? In the first of our special series of episodes looking at what a future world could look like, Madeleine Finlay speaks to author and historian Ben Wilson, Prof Jessica Davies and Prof Diane Jones Allen about how to create cities that are fairer, greener and more self-reliant.. Help support our independent journalism at theguardian.com/sciencepod

The environmental law charity ClientEarth and 13 other groups headed into a Flemish court this week in an effort to stop Ineos building a petrochemical plant that would be the biggest project of its kind in Europe for 30 years. Madeleine Finlay hears from correspondent Sandra Laville about how plastics are made, the environmental and health impacts of the process and what needs to be done to get a handle on plastic pollution. Help support our independent journalism at theguardian.com/sciencepod

Experts and campaigners have been pointing out the racial disparities in maternal healthcare for years. The latest report to highlight the issue comes from the House of Commons women and equalities committee. MPs behind the report have condemned the government’s failure to address the gulf in outcomes. So why are black and Asian women still more at risk from childbirth? Madeleine Finlay hears what it can be like to navigate the maternity system as a woman of colour, and speaks to Guardian health editor Andrew Gregory and Prof Shakila Thangaratinam about what lies behind the statistics and what can be done. Help support our independent journalism at theguardian.com/sciencepod

Sliced supermarket bread, ham, cheese, crisps, a fruit-flavoured yoghurt and a fizzy drink. If this sounds like a standard lunch, you’re not alone. The average person in the UK gets more than 50% of their calories from ultra-processed foods – otherwise known as ‘industrially produced edible substances’. Madeleine Finlay speaks to Dr Chris van Tulleken about what ultra-processed foods are really made of, how they have become a major part of our diets, and the impact they are having on our health. Help support our independent journalism at theguardian.com/sciencepod

Madeleine Finlay speaks to science correspondent Linda Geddes about trying out a virtual reality game that challenges you to keep your heart-rate down while facing a terrifying monster, why it could help with tackling anxiety, and whether the gamification of coping strategies could be the best way to integrate them into our every day lives. Help support our independent journalism at theguardian.com/sciencepod