Skin Anarchy

In this Masterclass episode of Skin Anarchy, Dr. Ekta Yadav welcomes back Dr. Barbara Paldus of Codex Labs for a compelling deep dive into integrative dermatology—a next-generation approach that treats skin not as a surface problem, but as a window into whole-body health.This conversation reframes chronic skin issues through a systems lens, exploring how the gut, brain, immune system, hormones, and microbiomes continuously communicate—and how disruptions in one system can ripple outward to the skin. Instead of asking “How do we suppress this flare?” Dr. Paldus challenges us to ask “Why is the skin signaling distress in the first place?”You’ll hear how stress, inflammation, microbiome imbalance, and intestinal permeability can quietly drive conditions like acne, eczema, rosacea, and psoriasis—often long before symptoms appear on the skin. The episode unpacks why conventional symptom-focused treatments sometimes fail to deliver lasting relief, and how root-cause care can create more durable, meaningful outcomes.Dr. Paldus also introduces a personalized teledermatology model that leverages biological data, at-home testing, and longitudinal tracking to design interventions tailored to each patient’s unique internal landscape. From hormone-driven breakouts to chronic eczema and immune dysregulation, the discussion highlights how precision diagnostics can guide smarter, more sustainable treatment strategies.At its core, this episode invites listeners to rethink skincare entirely—not as a cycle of stronger products or short-term fixes, but as a long-term investment in systemic resilience.If you’re curious about the future of dermatology, microbiome science, and why healing skin often starts far beyond the mirror, this episode offers a powerful preview of what root-cause, science-led care can look like.Listen to the full episode to explore how integrative dermatology is reshaping chronic skin care from the inside out.SHOP CODEXDon’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!*This is a sponsored collaborationSupport the show

In the third installment of the Skin Anarchy and Timeline Masterclass, Dr. Ekta Yadav sits down with Dr. Brad Currier, Manager of Clinical Trials at Timeline, for a behind-the-scenes look at what real evidence in longevity science and skincare actually requires.With a foundation in muscle physiology, exercise science, and aging research, Dr. Currier brings a performance-driven lens to longevity — reframing skin not as a cosmetic surface, but as a mitochondria-dense longevity organ, biologically linked to muscle health, metabolic resilience, and cellular energy. The episode explores why mitochondrial function may be one of the most underappreciated drivers of how both skin and the body age.At the center of the conversation is Timeline’s research on urolithin A, a postbiotic shown to support mitochondrial renewal. Rather than relying on marketing narratives, Timeline has built its platform on mechanism-first science, translating years of cellular research into human clinical trials — including biopsy-based studies that reveal measurable changes in collagen synthesis and skin structure.Dr. Currier also pulls back the curtain on the truth about clinical claims in beauty — explaining why many “clinically tested” labels lack rigor, how underpowered or biased studies distort results, and what separates meaningful, published human data from perception-based marketing. From wrinkle depth to hydration to barrier function, he outlines how Timeline measures outcomes that reflect real biological change — not just surface-level improvement.The episode ultimately reframes longevity as precision science, not hype — emphasizing the importance of human trials, mitochondrial health, and transparent evidence in an industry flooded with buzzwords.Listen to the full episode of Skin Anarchy to hear Dr. Brad Currier unpack what clinical validation should look like — and why the future of longevity skincare depends on measurable biology, not marketing promises.SHOP TIMELINEDon’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!*This is a sponsored collaborationSupport the show

In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Dr. Tiffany Libby for a clear, science-forward conversation on supplements, cellular energy, and why NAD biology has become such a focal point in modern longevity discussions. As interest in “aging better” grows, this episode cuts through hype to explore what NAD optimization can—and cannot—realistically do for skin and whole-body health.Dr. Libby brings a rare perspective to the conversation. As a board-certified dermatologist and Director of Mohs Surgery at Brown University Health, her work spans both skin cancer care and cosmetic dermatology, treating patients across decades of life. That long view has shaped her understanding of longevity not as youth preservation, but as maintaining resilience, repair capacity, and function over time—especially in the face of inflammation, environmental stress, and chronic disease.Much of the discussion centers on why supplements, particularly NAD boosters, are having a cultural moment. Dr. Libby explains that this surge reflects a gap in the healthcare system itself—one that prioritizes treatment over prevention. While supplements can offer support, she emphasizes they are not shortcuts. Longevity still rests on fundamentals: sleep, nutrition, movement, stress regulation, and inflammation control.The episode offers a practical breakdown of NAD (nicotinamide adenine dinucleotide), explaining its role in mitochondrial energy production, DNA repair, and cellular defense. As NAD levels decline with age, skin becomes less efficient at repairing damage, producing collagen, and maintaining barrier integrity. Crucially, Dr. Libby explains why NAD itself can’t be absorbed directly—and why precursors like nicotinamide riboside (NR) matter instead.Throughout the conversation, skepticism and safety remain central themes. In an underregulated supplement space, quality, dosing, and clinical validation matter. From a dermatologic standpoint, supporting mitochondrial health may help skin function closer to its biological potential—but only when paired with evidence-based care and realistic expectations.Listen to the full episode of Skin Anarchy to hear Dr. Tiffany Libby unpack the science of NAD, cellular energy, and why longevity begins with supporting biology—not chasing promises.SHOP TRU NIAGENDon’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!*This is a paid collaborationSupport the show

In this episode of Skin Anarchy, Dr. Ekta Yadav welcomes Carolina Reis Oliveira and Alessandra Zonari, co-founders of OneSkin, for a rigorous, eye-opening conversation that reframes skincare as a true longevity intervention. Part of the Lessons in Longevity series, this episode asks a bold question: what if skin aging isn’t cosmetic at all—but cellular, systemic, and deeply biological?OneSkin began not as a brand, but as a lab-based mission. Trained in stem cell biology, tissue engineering, and genomics, Carolina and Alessandra spent years growing real human skin in the lab to test existing products. What they found challenged the industry: many so-called “anti-aging” formulas increased inflammation, cellular stress, and long-term damage. Meanwhile, longevity science was accelerating—yet skin, the body’s largest organ, was being left out of the conversation.At the center of the episode is cellular senescence—a state where damaged cells stop dividing and begin secreting inflammatory signals that degrade surrounding tissue. In skin, this process weakens the barrier, disrupts collagen, and accelerates visible aging. Rather than masking symptoms, OneSkin set out to target this root cause. After screening hundreds of compounds, they developed OS-01, a proprietary peptide shown in lab models to significantly reduce senescent cell burden while increasing collagen—without irritation.The conversation also expands beyond the face. OneSkin’s decision to focus on body skin revealed something unexpected: improving the skin barrier may reduce systemic inflammation. Clinical data discussed in the episode suggests that healthier skin doesn’t just look better—it may influence whole-body aging.This episode is a must-listen for anyone curious about where skincare, biotech, and longevity science truly intersect.Listen to the full episode of Skin Anarchy to hear how OneSkin is redefining skin as a living organ—and why the future of longevity may start at the surface.SHOP ONESKINDon’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!Support the show

In this Fragrance Friday episode of Skin Anarchy, Dr. Ekta sits down with Pissara Umavijani, founder and perfumer of Parfums Dusita, for a quietly powerful conversation about perfume as emotion, memory, and meaning. In an industry increasingly driven by trends and virality, Dusita stands apart as a house built on poetry, patience, and feeling.Pissara shares her deeply personal journey—leaving Thailand to start over in Paris with a singular intention: to create fragrance that makes people feel. Entirely self-taught, she immersed herself in the craft of perfumery through persistence and intuition, guided by a belief that scent should communicate something human, not perform for attention. Even the name Dusita, which refers to a level of paradise in Thai culture, reflects this ethos—living with purpose, warmth, and emotional presence.Rather than relying on obvious cultural motifs, Dusita expresses Thai heritage through values: gentleness, hospitality, compassion, and balance. These qualities shape not only the fragrances themselves, but how the brand engages with people—inviting closeness rather than spectacle.At the heart of every Dusita fragrance is poetry written by Pissara’s late father. Each poem serves as an emotional blueprint, translated into scent rather than illustrated literally. This approach comes to life in beloved creations like Tonka Latte, a soft, comforting gourmand inspired by warmth and love, and Pavilion d’Or, a serene composition that captures balance and stillness without adhering to a single category.Throughout the conversation, Pissara returns to one guiding principle: balance. For her, great perfumery isn’t about intensity—it’s about harmony, evolution, and restraint. Dusita’s fragrances don’t demand attention; they reward it.Listen to the full Skin Anarchy episode to hear how poetry, Thai cultural values, and emotional honesty shape Parfums Dusita—and why the most powerful fragrances are often the quietest ones.SHOP Parfums DusitaDon’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!Support the showSupport the show

In this episode of Skin Anarchy, Dr. Ekta Yadav is joined by Dr. Yannis Alexandrides and Eva Alexandridis, the husband-and-wife team behind 111 Harley St. and 111SKIN, for a candid, science-forward conversation on regenerative aesthetics, protocol-based skincare, and what longevity really looks like when it’s rooted in medicine—not marketing.111SKIN didn’t start as a beauty brand. It began in the operating room. Dr. Alexandrides shares how his work in facial plastic surgery led him to develop skincare that could support faster healing and stronger outcomes after surgery—when nothing on the market met his clinical standards. What surprised him most wasn’t just improved recovery, but the long-term transformation in skin quality patients experienced once healing was complete. That insight became the blueprint for translating surgical-grade science into daily care.A central theme of the episode is maintenance. Procedures, Dr. Alexandrides explains, are only as successful as the skin’s baseline health. Eva expands on this philosophy, emphasizing that 111SKIN was never about instant fixes—it was about training skin to behave better over time. Longevity, in their view, is built through consistency, restraint, and respect for biology.The conversation also dives into the brand’s measured approach to advanced technologies like exosomes—used as targeted protocols rather than trends—and the broader shift in aesthetics toward regeneration over replacement. From deep plane techniques to micrografting, Dr. Alexandrides explains why modern plastic surgery is moving away from excess and toward preservation.Throughout the episode, one message remains clear: longevity aesthetics aren’t about changing who you are—they’re about supporting skin health so you can look like yourself, for longer.Listen to the full episode of Skin Anarchy to hear Dr. Yannis Alexandrides and Eva Alexandridis unpack the science behind 111SKIN, regenerative skincare, and the future of evidence-based aesthetic care.SHOP 111SKINDon’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!Support the show

In this episode of Skin Anarchy, Dr. Ekta sits down with Natasha Denona for a rare, reflective conversation that traces the creative and philosophical roots of one of modern makeup’s most influential brands. Known for palettes that have become industry benchmarks, Natasha opens up about how her work has always been driven less by trends—and more by intention, education, and respect for the user.Growing up between science and art shaped everything. Natasha’s mother, a chemist in inorganic chemistry, exposed her early to laboratories, precision, and technical thinking. While chemistry itself didn’t immediately click, the discipline behind it did. That structured curiosity later resurfaced in how Natasha approaches formulation, texture, and product architecture—where creativity is always grounded in control.Before makeup, there was painting, theater, and dance. Natasha shares how color became both emotional language and psychological tool, first explored through art and stage makeup. That foundation explains why her palettes feel cohesive yet expressive—each one designed as a complete story rather than a collection of random shades.A defining theme of the episode is education. Natasha doesn’t create products to sit on a shelf; she designs tools that teach. Long before “educational beauty” became a marketing buzzword, her launches embedded technique—guiding users through layering, sculpting, and dimension the way professional artists actually work.Rather than chasing novelty, Natasha deliberately builds for longevity. Palettes like Biba and Camel weren’t designed for a moment—they were designed to last across ages, skin tones, and styles. Inclusivity, she explains, has always been non-negotiable, not performative. Her decision to launch 52 foundation shades wasn’t strategic—it was personal.Throughout the conversation, one belief remains constant: the product should be the star. Natasha never wanted her image to overshadow the work itself.Listen to the full episode of Skin Anarchy to hear Natasha Denona reflect on creativity, inclusivity, and why true innovation in beauty comes from intention—not trends.SHOP NATASHA DENONA CHAPTERS:(0:02) - Welcome & Introducing Natasha Denona(1:14) - Growing Up Around Science, Art, and Photography(4:43) - Early Relationship With Color, Makeup, and Expression(6:11) - From Dance & Modeling to Makeup Artistry(7:26) - Building Iconic Color Stories & Palette Philosophy(9:05) - Inclusivity as a Core Creative Principle(13:19) - Creating Complexion Products at Scale(17:05) - Longevity, Creativity, and Avoiding Trends(24:08) - Entrepreneurship, Visibility, and Authentic LeadershipPlease fill out this survey to give us feedback on the show!Don’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf! Hosted on Acast. See

In this episode of Skin Anarchy, Dr. Ekta sits down with Denise Vasi, founder and creative force behind MAED, for a thoughtful conversation about building beauty with intention, patience, and care. Denise’s path into the industry began early—signed to Ford Models and immersed in on-set artistry long before social media shaped beauty culture. Those formative years, paired with memories of her grandmother’s at-home esthetic rituals, planted the seed for a philosophy rooted in preparation, respect, and craft.Before MAED ever existed, Denise built something rarer than hype: community. Through years of honest storytelling around wellness, motherhood, and clean living, she created a dialogue with women who trusted her voice. That trust shaped MAED’s slow, deliberate evolution. Rather than chasing trends or speed, Denise chose to listen—developing products only when they solved real, lived problems.At the heart of the brand is a deceptively complex product: the red lip. Denise unpacks why most formulas fail—dryness, poor undertones, and exclusion baked into development—and how MAED set out to fix that. Comfort came first, followed by rigorous testing across skin tones, lip shapes, ages, and backgrounds. Inclusivity, she explains, isn’t a campaign—it’s formulation, design, and function.Central to MAED’s ethos is one guiding principle: care before color. Lips lack oil glands and cannot repair themselves without real barrier support. MAED’s formulas focus on hydration, resilience, and wear—so color performs because the foundation is healthy.Beyond product, the conversation explores beauty as ritual and self-expression. The red lip becomes more than pigment—it’s confidence, protection, and presence.Listen to the full episode to hear Denise Vasi share the philosophy behind MAED, the science of lip health, and why meaningful beauty innovation starts with care—not trends.SHOP MAED and learn more on their social media!CHAPTERS:(0:02) - Introduction & Welcoming Denise Vasi(0:59) - Early Career: Modeling, Beauty Sets & Formative Influences(2:16) - Building Community Through Editorial & Made.co(4:48) - Slow Beauty, Brand Intention & Resisting Trend Cycles(7:13) - Reimagining the Modern Red Lip(8:04) - Formulation, Testing & True Inclusivity(12:16) - What Inclusivity Really Means in Beauty(16:30) - Lip Health, Barrier Science & Care-First Formulation(23:10) - Care Before Color & The Cultural Power of a Red LipPlease fill out this survey to give us feedback on the show!Don’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf! Hosted on Acast. See acast.com/privacy for more information.

In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Michele Henry, founder and CEO of FACE FOUNDRIÉ, to explore how the facial industry is being quietly—but fundamentally—rewritten. What began as a personal frustration became a scalable solution: professional skincare that’s consistent, accessible, and designed for real life, not just special occasions.After her third child, Michele found herself stuck between facials that were either overly luxurious, prohibitively expensive, or wildly inconsistent. She wanted results, education, and efficiency—without the intimidation. When that middle ground didn’t exist, she built it. FACE FOUNDRIÉ's facial-bar model challenged long-standing spa norms by focusing exclusively on high-quality facial services delivered quickly, clearly, and consistently.A central theme of the conversation is accessibility. Michele rejects the idea that skincare should feel exclusive or confusing. Transparent pricing and monthly memberships make frequency possible—and frequency, she explains, is what actually drives results. Prestige may impress, but approachability scales.Behind the scenes, FACE FOUNDRIÉ's real innovation is operational. Standardized protocols ensure clients receive the same experience across locations, while personalization comes through targeted enhancements layered on top—not improvisation. Technology tracks treatments and progress, reinforcing consistency as a clinical standard.The episode also tackles a common misconception: that advanced at-home products can replace professional care. Michele makes the case that treatments and products work best together—services like dermaplaning, peels, and extractions create the conditions for skincare to truly perform.At its core, FACE FOUNDRIÉ is about emotional safety as much as skin health. Clients choose how they want to experience their facial—quiet or educational—in spaces designed to feel welcoming, not intimidating.Listen to the full episode to hear how Michele Henry is redefining professional skincare—making results-driven facials scalable, sustainable, and built for everyday life.Learn more about Face Foundarié on their website and social media!CHAPTERS:(0:02) - Introduction & Face Foundrie Overview(0:59) - Michele’s Personal Journey & The Origin Story(2:16) - Reimagining the Facial Bar Model(3:23) - Early Trial, Error & Rapid Pivot(5:26) - Accessibility, Memberships & Breaking Prestige Barriers(7:16) - Results-Driven Protocols vs Luxury Spa Experiences(8:23) - Consistency, Personalization & Scalable Systems(10:26) - Franchising Face Foundrie & National Growth(13:35) - Technology, AI & The Future of Skin Care ExperiencesPlease fill out this survey to give us feedback on the show!Don’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf*This is a paid collaborationSupport the show

In this episode of Skin Anarchy, Dr. Ekta Yadav sits down with Smitha Rao—biotechnologist, longtime beauty innovator, and founder of Pareva Beauty—for a grounded, science-first conversation on what skin longevity actually means. Part of the Lessons in Longevity series, this episode challenges the tired idea of “anti-aging” and reframes skincare as long-term biological support rather than surface-level correction.With nearly two decades in biotech and beauty, Smitha brings a rare perspective shaped by molecule development, patents licensed across major brands, and leadership roles behind more than 200 products. That experience revealed a growing disconnect: while consumers want clarity and real science, the industry often defaults to hype, fear-based claims, and trend chasing. Pareva Beauty was born as a response—built on transparency, rigor, and the belief that longevity is about extending skin function and resilience, not reversing time.At the center of the discussion is Molecur 3™, Pareva’s proprietary, plant-based technology inspired by the Hallmarks of Aging. Smitha explains how targeting inflammation, cellular stress, and age-related decline—rather than isolated “anti-aging” claims—creates a more realistic and sustainable path for skin health. The conversation also dives into plant-derived exosomal signaling, why it differs from human-derived systems, and how it offers a safer, scalable approach for topical longevity skincare.Together, Dr. Ekta and Smitha unpack why fewer, better-designed products outperform complex routines, why transparency matters more than vague “clean” labels, and how longevity skincare must earn trust through data—not promises.Listen to the full episode to hear how Smitha Rao is helping redefine the future of skincare—where science, honesty, and long-term skin health come first.Shop Parëva Beauty and use code SA20 for 20% through 3/17.CHAPTERS:(0:02) - Introduction, Lessons in Longevity & Smitha Rao(1:21) - From Biotech to Beauty Innovation(2:50) - Why Pareva Was Created & The Longevity Gap(3:33) - Defining Skin Longevity & Extending Your Prime(5:38) - Rejecting Anti-Aging & Reframing Aging Quality(8:51) - Molecure 3™: Hallmarks of Aging Inspiration(10:27) - Plant Stem Cells, NAD⁺ & Exosome Signaling(14:00) - Exosomes Explained: Plant vs Human-Derived(22:51) - Simplifying Skincare: Fewer Steps, Better ResultsPlease fill out this survey to give us feedback on the show!Don’t forget to subscribe to Skin Anarchy on Apple Podcasts, Spotify, or your preferred platform.Reach out to us through email with any questions.Sign up for our newsletter!Shop all our episodes and products mentioned through our ShopMy Shelf!*This is a paid collaboration Hosted on Acast. See acast.com/privacy for more information.