What did Substack think about the NYTimes article "Why We’re Freaking Out About Substack" [1:01]What is Substack? [4:40]The issues with social media content models and how Substack is different [5:54]What about the echo chamber? [8:54]Turning cultural principles (e.g., freedom of the press) into actual culture [12:00]Will Substack replace traditional media? [14:01]Would Donald Trump be welcome on Substack? [20:35]Why do they pay writers advances? And why is that controversial? [23:33]The origins of American journalism aren't what most people think [27:20]Non-fungible writers and the Substack model [31:45]Ad-supported media predates the internet  [39:21]How do I price my Substack? [43:39]Substack, political topics, and culture wars: "We knew we were running towards the fire." [45:01]How do you prevent algorithms from slanting the platform [51:06]Substack's vision for the future of media [55:27]Boss Talk is the Clubhouse show where a16z cofounder Ben Horowitz and Ali Ghodsi, the Founder/CEO of Databricks, discuss CEO stuff, leadership stuff, management stuff... boss stuff. Live every Tuesday 5-6pm on Clubhouse. For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse.  

eBay to today, a brief history of collectibles and tech [1:03]Are collectibles about sentiment or investment? [5:13]How do you bring the excitement of a collection to digital goods? [13:34]Is the future of all collectibles digital? [20:20]The role of blockchain and NFTs [26:39]Are collectible marketplaces different from other marketplaces? [32:19]Importance of live video [38:28]Celebrity interest in NFTs: will it last? [40:46]Are collectibles a bubble? [43:13]Listen live to the a16z show People Behind the Product Wednesdays noon-1pm PT with the a16z consumer team.

For videos of the NFT Virtual Summit, visit a16z.com. Session 1: The Future of the Digital Ownership Economy with Dan Boneh (Stanford University) and Chris Dixon (a16z)What is an NFT? [3:01]Why are NFTs  so big right now? [7:04]The most exciting programmable ownership structures  [11:36]NFTs and composability: what can  you do with NFTs? [15:16]How would quantum impact the immutability of the blockchain ledger? [18:40]How important is decentralized permanent storage for NFTs... and when will we get there? [20:54]Session 2: The New Creative Economy with Kayvon Tehranian (Foundation Labs)How Foundation Labs works with creatives [24:54]Digital Art NFTs: Nyan Cat, Ethiopian Artists Collective, Rafael Rozendaal, Aphex Twin, and Reuben Wu [28:08]The Edward Snowden NFT [33:45]Why is tracking provenance powerful for creatives? [36:34]Creators becoming collectors and crypto investors [39:00]Can you buy an NFT on one platform and sell on another and still track provenance? [41:31]Session 3: NBA Top Shot and Other NFTs on the Flow Blockchain with Dan Boney (Stanford University) and Dieter Shirley (Dapper Labs)The Flow Blockchain from CryptoKitties to NBA Top Shot [45:18]What is NBA Top Shot, and what was the hardest part of building it [50:34]Building a successful user experience [52:55]Negotiating with the NBA [54:32]The biggest challenges for NFTs going mainstream [56:55]Why did they build their own blockchain? [1:01:23]Building ERC-721 and lessons learned on crypto standards [1:04:00]Session 4: Going Beyond Collectibles and The Future of Tokens for Creators with Kevin Chou (Rally) and Chris Dixon (a16z)What are social tokens? (and how is Portugal. The Man. using them) [1:05:51]What are the roles of fungible and non-fungible tokens? [1:08:30]NFTs in gaming now and what's next [1:14:35]Pricing and price discovery for NFTs [1:17:39]Tips for launching a social token [1:19:06]How does Rally make money? [1:22:08]Session 5: NFT Use Cases Today and Tomorrow with Devin Finzer (OpenSea) and Katie Haun (a16z)What does OpenSea do? [1:26:14]Why the sudden interest in NFTs? [1:28:35]What can and can't be turned into an NFT [1:30:13]How NFTs can interact with the physical world [1:32:33]Virtual lands and the metaverse economy [1:35:14]Virtual concerts and NFT tickets [1:40:44]Mixing and remixing NFTs [1:43:04]Session 6: The Accidental Art DAO with pplpleasr (digital artist)pplpleasr's NFT "Apes Together Strong" that was auctioned as part of The NFT Summit serves as the artwork for this podcast.    

What inspired Eric and Sam to start Dyno [4:09]How does the use of ML impact Dyno's GTM [10:40]The current challenges of gene therapy [21:43]Why Dyno wants to be a horizontal platform for gene therapy [30:56]How does Dyno think about competition [44:23]After party and audience Q&A [52:01]It's Time to Heal, Mondays at 5pm PT on Clubhouse. Join the a16z bio team — Jorge Conde, Vineeta Argawala, Julie Yoo, and Vijay Pande — plus special guests every week as they explore all the ways that biology is technology.

Note: the recording of this episode starts a minute or two into the show.Ali recommends: The Hard Thing about Hard Things  by Ben Horowitz [0:18]Ben recommends: High Output Management by Andy Grove [4:36]Marc recommends: Who Really Matters: The Core Group Theory of Power, Privilege, and Success by Art Kleiner [10:48]Best read for enterprise sales: Power Base Selling by Jim Holden, et al [13:06]Microsoft, Google, government contracts, and politicized workplaces [16:28]Marc recommends: The Tyranny of Structurelessness by Jo Freeman [29:32]Ali recommends: Radical Candor by Kim Scott [33:19]Ben recommends: No Rules Rules: Netflix and the Culture of Reinvention  by Erin Meyer and Reed Hastings [44:19]Ben recommends: Working Backwards: Insights, Stories, and Secrets from Inside Amazon by Colin Bryar [50:28]How they are approaching the return to work and remote work [53:00]Boss Talk is the Clubhouse show where a16z cofounder Ben Horowitz and Ali Ghodsi, the Founder/CEO of Databricks, discuss CEO stuff, leadership stuff, management stuff... boss stuff. Live every Tuesday 5-6pm on Clubhouse. For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse. 

How Ben took over Take Two [1:42]How digital distribution and publishing changed gaming [8:36]What is a next generation publisher? [13:51]Can publishers add value as tastemakers? [17:36]How do you make sure studios ship on time? And in the era of persistent game worlds, does it matter? [22:01]Lessons learned from Take Two [27:27]Taking the long view of the creative process — "Every overnight success was ten years in the making." [30:53]Is there a successful game that surprised Ben? [37:08]What's the next big gaming platform? [46:07]Where will subscription models lead? [52:06]Sabbaticals and life advice [56:50]Join a16z partners and special guests from the gaming industry for discussions on games, game development, online communities, esports, AR/VR, and everything in between. Wednesdays at 5pm PT. For more a16z Clubhouse shows, follow the a16z Club on Clubhouse or visit www.a16z.com/clubhouse. 

Robert's foundational experiences growing up [3:03]His introduction to computers, how he got an internship at Bell Labs, and what he learned there [6:38]Why he studied chemical engineering [13:15]Working at Kraft and engineering macaroni and cheese [15:08]Why he moved to investing [18:12]How he realized that it made sense to do buyouts in enterprise software [23:19]Creating a common playbook for running enterprise software companies [30:45]How does he think about retaining vs replacing founders [34:54]Vista's approach to evaluating talent and getting people in the right roles [37:02]Robert's next ambition [46:10]His philosophy of philanthropy [49:15]Why he paid off the student debt for Morehouse College Class of 2019 [1:00]For our upcoming schedule of Clubhouse conversations, follow the a16z Club on Clubhouse or visit a16z.com/clubhouse. 

What happened at Basecamp and could it have gone differently? [3:51]When did Basecamp turn into a 4B? [7:45]Why were buyouts  a good policy for Basecamp and Coinbase? [10:26]Why not have a more moderate policy? [11:56]What makes something "political"? [14:45]What about when political issues have a personal impact on employees? [19:18]What happened at Peloton and why they apologized [22:53]When should you issue an apology?  [26:12]How do you rebuild trust after you apologize? [28:32]Audience Q&A [33:44]"4B with Margit" is a Clubhouse show for raw and unfiltered advice from comms and marketing experts who have seen it all, as well as insider stories from the builders and pioneers who were in the trenches. Think “Scandal” meets “Halt and Catch Fire.” Catch it live Wednesdays 4-5 PST. For our upcoming schedule of Clubhouse conversations, follow the a16z Club on Clubhouse or visit a16z.com/clubhouse. 

What are red teams and blue teams? [2:03]How Cedric cracked Mac Gatekeeper [6:55]Apple's response [15:22]Cedric's craziest hack [19:24]Red team advice for the blue team [22:02]Audience Q&A [26:31]🔐Breach of the Week 🔐looks at who got hacked, how it happened, and what it means for the industry. 🎙With hosts Joel de la Garza (a16z Security Operating Partner) and Geoff Belknap (CISO LinkedIn) on Clubhouse every Thursday 5-5:30pm.

On this episode of the a16z Bio Clubhouse Show, a16z general partners Vineeta Agarwala, Julie Yoo, Vijay Pande, and Jorge Conde talk to guest Shantanu Nundy, the Chief Medical Officer of Accolade. The conversation covers Dr. Nundy's new book, "Care After Covid: What the Pandemic Revealed Is Broken in Healthcare and How to Reinvent It",  the next steps in the evolution of hospitals, interoperability (or lack thereof), and more.