Woody Harrelson chats with Rick Rubin, a renowned music producer celebrated for his work with legends like LL Cool J and Johnny Cash. They dive into Rick's transformative journey through music, from punk to hip-hop, and the origins of Def Jam. The conversation touches on early influences, mental health struggles, and the unpredictability of music production. Rick reflects on creativity, collaboration, and the lessons learned from iconic collaborations. Their friendship adds a warm backdrop to this exploration of artistic identity and evolution.

Tom Selleck, the iconic actor known for his role in Magnum, P.I., joins Ted Danson for a lively chat. He shares hilarious anecdotes from his Magnum days and reveals details about an audition for Mae West that took an unexpected turn. Tom discusses how Leonard Nimoy turned a potential disaster around while making Three Men and a Baby. The conversation also touches on strange ghost rumors surrounding the film set, blending humor and nostalgia as they reminisce about Hollywood's past and the pressures of fame.

Rob Lowe, a Hollywood star, joins Ted Danson for a candid chat. They explore Lowe's childhood epiphany that sparked his move to Hollywood and his thoughts on the Brat Pack. He shares his secrets to a lasting marriage and the importance of recovery in his life. In a light-hearted moment, Ted asks Rob to clarify an amusing adult phrase. Their conversation is filled with humor and insights about personal growth, family dynamics, and navigating fame in the entertainment industry.

Jeff Goldblum, known for his iconic roles and quirky charm, joins Ted Danson, a beloved actor with a storied career. They reminisce about their first meeting and share insights into their unique acting styles. Jeff reveals his admiration for Ted and even serenades him with a catchy tune! The two delve into their influences and the foundations of their craft, blending humor and nostalgia, while discussing the intersection of music and film in their lives.

George Wendt, beloved for his portrayal of Norm Peterson on Cheers, joins Ted Danson and Woody Harrelson to reminisce about their iconic sitcom days. They share hilarious misadventures, including a stormy escapade influenced by mushrooms and the chaos surrounding their send-off. Wendt reveals he once recommended Woody for a major role, adding a personal touch to their laughter-filled discussion. The camaraderie and playful spirit of their shared experiences shine through, making it a delightful trip down memory lane.

Flea, the iconic bassist of the Red Hot Chili Peppers, joins his long-time friend Woody Harrelson and new pal Ted Danson for a deep dive into creativity and spirituality. They discuss overcoming addiction and how a powerful message from Flea's daughter reshaped his life. The trio reflects on life in Los Angeles, the significance of community, and the transformative power of music education. Flea also hints at some amusingly compromising footage of Woody, adding a playful twist to their heartfelt conversation.

Lisa Kudrow, a pioneering actress known for her iconic role in Friends, chats with Ted Danson about her unique comedic journey. They dive into her unforgettable appearance on Cheers and her experience navigating the whirlwind of fame after Friends. Kudrow shares her early passion for evolutionary biology before comedy, while Danson reflects on his own challenges as Sam Malone. The conversation also touches on the healing power of sitcoms and the significance of embracing individuality in a quirky world.

Ted Danson and Woody Harrelson chat with Laura Dern about her love for acting, writing a book with her mom, and Oscar nominations. They also discuss the importance of friendships in the industry, acting vulnerability, and switching to Consumer Cellular for savings.

Ted Danson chats with comedian Eric Andre about his unique projects like Bad Trip and The Eric Andre Show. They discuss Eric's comedy style, dealing with anxiety, and personal loss. The episode covers topics like creating lovable pranks for movies and navigating the entertainment industry, as well as exploring therapy, performance anxiety, and MDMA therapy for PTSD.

D'Arcy Carden, Ted Danson, Rashida Jones, and Mike Schur dive into Wikipedia trivia starting with Bruce Springsteen, leading to unexpected connections like the US Olympic Equestrian team. They play a hilarious music guessing game, mixing up artists and songs, with laughter and challenges.