34 days after it first formed at the far end of the Indian Ocean, record-breaking Cyclone Freddy made a repeat landfall on Mozambique as well as passing over Malawi, causing extensive damage and loss of life. Climate scientists Liz Stephens and Izidine Pinto join Roland to give an update on the destruction and explain how Cyclone Freddy kept going for an exceptionally long time. At the Third International Human Genome Summit in London last week, Professor Katsuhiko Hayashi announced he had created baby mice from eggs formed by male mouse cells. Dr Nitzan Gonen explains the underlying science, whilst Professor Hank Greely discusses the ethics and future prospects. And from one rodent story to another, SARS-CoV-2 has been detected in brown rats scurrying around New York sewers. Dr Thomas DeLiberto from the US Department of Agriculture gives Roland the details. When imagining a robot, a hard-edged, boxy, humanoid figure may spring to mind. But that is about to change.CrowdScience presenter Alex Lathbridge is on a mission to meet the robots that bend the rules of conventionality. Inspired by how creatures like us have evolved to move, some roboticists are looking to nature to design the next generation of machines. And that means making them softer. But just how soft can a robot really be?Join Alex as he goes on a wild adventure to answer this question from listener Sarah. He begins his quest at the ‘Hello, Robot’ Exhibition at the Vitra Design Museum in Weil am Rhein, Germany to define what a robot actually is. Amelie Klein, the exhibition curator, states anything can be a robot as long as three specific criteria are met (including a cute cuddly baby seal). With this in mind, Alex meets Professor Andrew Conn from the Bristol Robotics Lab who demonstrates how soft materials like rubber are perfect contenders for machine design as they are tough to break and - importantly for our listener’s question - bendy.Alex is then thrown into a world of robots that completely change his idea of what machines are. He is shown how conventionally ‘hard’ machines are being modified with touches of softness to totally upgrade what they can do, including flexible ‘muscles’ for robot skeletons and silicon-joined human-like hands at the Soft Robotics Lab run by Professor Robert Katzschmann at ETH Zurich. He is then introduced to robots that are completely soft. Based on natural structures like elephant trunks and slithering snakes, these designs give robots completely new functions, such as the ability to delicately pick fruit and assist with search and rescue operations after earthquakes. Finally, Alex is presented with the idea that, in the future, a robot could be made of materials that are so soft, no trace of machine would remain after its use...Image credit: Jack McBrams/Getty Images Producer: Roland Pease Assistant Producer: Sophie Ormiston

We meet experts at the Human Genome Editing Summit in London, seeking to cure genetic disease and ensure that it is safe and available to all.Roland Pease hears from Victoria Gray, the first person to be cured of the debilitating and life-shortening disease sickle cell anaemia by gene editing, and from the scientists making it possible.Also, the prospect of work to attempt gene rescue in fetuses before they are born. But the technology is expensive and complex. The question troubling the participants is to ensure people across the world can benefit from it, not just the rich and privileged.And what are the limitations of gene editing? Can it be made more effective, safer? And what of gene edits that will be inherited by future generations?

The long rains of East Africa are forecast to fail again, for the third year running, precipitating a food crisis affecting millions. Science In Action explores the science of the drought, hears about new methods improving forecasts, and what is unusual about the region that makes it so vulnerable.When we think of helium, for many of us balloons and squeaky voices come to mind. But the noble gas is critical for many aspects of modern life – and we’re facing a global shortage. Dr Annie Cheng and her colleagues at the University of Oxford are attempting to solve this by creating a model that has the potential to locate previously untapped reservoirs.CrowdScience listener Eric, in New Zealand, has noticed his wisteria growing towards a neighbouring tree. He thinks that it actually knows where it’s going. But how can a plant have a sense of direction?Plants don’t have the advantage of brains or eyes, but that doesn’t seem to stop them from being clever enough to find out from their environment where to move and how to get there – all while being rooted to the spot.Marnie Chesterton visits the Natural History Museum and Kew Gardens in London, home to the largest collection of living plants in the world, to discover how plants make their manoeuvres, and talks to botanists and plant biologists for the latest findings on the mysterious life of climbing plants.Image by Gerald Anderson/Anadolu Agency via Getty ImagesProducer: Roland Pease Assistant Producer: Sophie Ormiston

DNA has revealed potential animal COVID carriers at the Wuhan market, but what does that tell us about the start of the pandemic? Roland talks to two of the experts behind the new analysis: Dr Florence Débarre and Professor Eddie Holmes.Also, we look into Europe’s grand new space ambitions. ESA director general Josef Aschbacher gives Roland the details of the space agency’s out-of-this-world plans.And Beethoven's last DNA: a hairy story of his family and genetic afflictions. Dr Tristan Begg shares how the composer’s tresses unlocked new information about his life and death.Inside our gut lives an entire ecosystem of bacteria and microbes, called the microbiome. In fact, the human body contains trillions of microorganisms, which outnumber our cells by ten to one. This means that technically, we are more microbe than human. But not only do these microbes rely on us to survive, we also rely on them too for vital bodily functions. So what impact do these trillions of microbes have on our health? That’s the question that’s been bothering CrowdScience listener Russell, from Canada.Presenter Caroline Steel sets out to investigate. She visits the only museum dedicated to microbes in the world to explore what exactly these microbes inside us are, what they do and why we have so many of them inside our bodies. How important is our microbiome for our survival and what impact can it have on our physical health?Caroline finds out what impacts our microbiome, what we can do to improve our inner ecosystem, and how our microbes can take a disturbing turn on us after we die.Image credit: Eddie HolmesProducer: Roland Pease Assistant Producer: Sophie Ormiston

Cyclone Freddy has made landfall on Madagascar, leaving destruction in its wake. At the time this edition of Science In Action is going to air, Freddy is on course to reach Mozambique and South Africa. Freddy, which has been gaining strength since it originally formed on the 30th of January, is the most powerful southern hemisphere cyclone on record. Professor Francois Engelbrecht provides the science behind the storm system. In the centre of our galaxy, an enormous cloud is heading towards the Milky Way’s supermassive black hole. Dr Anna Ciurlo tells us that this is a unique opportunity to study the influence of the black hole on the cloud’s shape and properties. We’ve heard a lot about balloons floating above Earth recently… but what about sending balloons to Venus? That’s exactly what Dr Siddharth Krishnamoorthy is proposing in order to study Venus’s seismic activity. Recorders on a “floatilla” above the planet’s surface could listen into Venus-quakes and reveal Venus’s mysterious past. And closer to home, scientists have discovered a new layer in the Earth’s core. We journey into the very centre of the Earth with Professor Hrvoje Tkalčić, who tells Roland what the innermost inner core can teach us about our planet’s past. And, If, like this week’s Crowdscience listener Lili, you’re an avid gymgoer, you may well have wondered where your fat disappears to when you exercise?Well, the short answer is that we convert it to energy that powers a whole range of physical processes, from breathing to walking as well as lying down and doing nothing. But the science behind energy expenditure is a little more complicated than that.Presenter Anand Jagatia pops on an exercise bike to have his metabolism measured, and learns that he may be relying on an entirely different source of fuel as he works up a sweat. But is all that hard work worth the effort it involves? Recent research suggests there's a limit to the number of calories us humans can burn, and that doing physical activity isn’t a sure-fire way to keep trim.Even hunter-gatherers who walk 13,000 steps a day have the same metabolic rate as the average American. So if working out isn't the best way to lose weight, how about harnessing our own fat to tackle the complications of obesity? It used to be thought brown fat was exclusive to babies (and bears) but we now know adults have some of it too, and it seems to play a vital role in combatting a range of chronic diseases including hypertension and diabetes.Image: NASA Earth Observatory image by Lauren Dauphin, using VIIRS data from NASA EOSDIS LANCE, GIBS/Worldview, and the Joint Polar Satellite System (JPSS). Producer: Roland Pease Assistant Producer: Sophie Ormiston

In the decade since the genome editing capabilities of CRISPR-Cas9 emerged, research into novel medicines has boomed – but alongside progress comes new ethical considerations. Controversy erupted in 2018, when Chinese scientist He Jiankui created the first babies with edited genomes. After leaving prison last year, he’s now back in the lab trying to raise support for new research but refuses to discuss the ethical implications of his work. Dr Joy Zhang recently arranged a bioethics seminar and invited He Jiankui, it was the first time he’d agreed to engage with a global cohort of CRISPR scientists since returning to his research.Going back in time from cutting-edge to ancient technology, some of the oldest stone tools ever used by human ancestors have been unearthed at a fossil site in Kenya. Professor Tom Plummer talks us through the findings and how important the tools were in our evolution.And we immerse ourselves in the mysterious sounds of the Arctic and Antarctic, from singing ice to the man-made noises of oil and gas drilling. These dramatic soundscapes, created for the Polar Soundscapes project, showcase just how busy our oceans are. Dr Geraint Rhys Whittaker, composer and project lead, believes a novel approach may be required to prompt climate action.Yoga benefits our health in many ways, say the yogis, but which claims are backed up by science? Can yoga actually alleviate depression, fix lower-back pain or even reduce cardiovascular disease?Presenter Marnie Chesterton gets into her Lotus (position) and finds out first-hand at a class. Whilst in warrior one, she discusses the potential physical and mental health benefits of this ancient art of stretching, balance and movement with her class teacher. Returning from mat to studio, Marnie puts some of those claims to experts around the globe. She investigates the evidence to find out whether health boosting properties are the key to yoga's enduring popularity.Image Credit: Anthony WallacePresenter: Roland Pease Producer: Harrison Lewis Assistant Producer: Sophie Ormiston

In the early hours of Monday, a powerful earthquake hit Kahramanmaras in Turkey. Nine hours later another struck. When this edition of Science in Action first aired, 19,000 people were reported to have died, but that number was expected to rise. Back in 2016, Professor Asli Garagon and her colleagues accurately predicted that an earthquake of this size was coming. Using GPS, they were monitoring the East Anatolian fault to calculate energy building between the plates. With such accurate insight could Turkey have been better prepared?Ross Stein, seismologist and founder of Temblor, a Californian consultancy that specialises in assessing hazard risk, estimates the plates moved at 5,000 mph. The movement of the plates may have built up pressure in other parts of the country. And finally, Tiziana Rossetto, a civil engineer at University College London, knows better than most that earthquakes do not kill, buildings do. She tells Roland how the combination of earthquakes and subsequent aftershocks appear to have even destroyed buildings that were purposely built to withstand them. Also, Why does the thought of giving a talk to an audience fill so many of us with sheer terror? Marnie Chesterton investigates for listener Nhial, who has seen his fellow students in Morocco become panic stricken at the prospect and wants to know the reason for our anxiety. According to one study, 77 per cent of us share that fear.Marnie finds out about the relationship between stress, our brains and our voices from research associate Dr Maria Dietrich at the University Hospital, Bonn University. She talks to Nhial’s tutor, Professor Taoufik Jaafari, at Hassan II University of Casablanca about the challenges facing his students. And she visits the National Theatre in London to get some expert training from Jeannette Nelson, head of voice, who works with some of the world’s leading actors.Could there be an evolutionary explanation for the purpose of public speaking? Is it something we actually need to be good at? Marnie asks evolutionary psychologist Professor Robin Dunbar at Oxford University and gets some surprising answers. She meets psychologist Dr Preethi Premkumar at London South Bank University, who has developed virtual reality therapy with colleagues at Nottingham Trent University, and tries out the treatment herself.Image: Aftermath of the deadly earthquake in Gaziantep Credit: REUTERS/Dilara Senkaya

Pull on an extra layer and stay toasty whilst Science in Action braces for a deep freeze. Whilst we know plenty about the ice on the Earth’s poles, Roland is on a chilling journey to see what can be found in deep space. Professor Christoph Salzmann and Professor Andrea Sella at University College London have produced a new phase of ice. Roland heads to the laboratory to see how the usual crystalline ice, found in ice cubes and icebergs, can be broken down and arranged into a new structure. The James Webb Space Telescope has detected the coldest ices to date, deep within a molecular cloud in outer space. Professor Melissa McClure describes how these clouds harbour a variety of different molecules potentially capable of forming the basic building blocks for life. From the edges of the universe to something a little closer to home, Professor Geoff Collins and colleagues have discovered odd tectonic plate activity on icy Europa, one of Jupiter’s moons.We generate a huge amount of noise, whether it’s our rumbling roads, pumping parties, or talkative tourists. And the topic of noise also generates a lot of questions from our listeners. In this episode we explore three of them, with the help of acoustic scientist Kurt Fristrup and neuropsychologist Catherine Loveday.Listener Dominique finds it hard to experience even one minute of a natural soundscape without some intrusion of human-made noise. He wonders how noise pollution is affecting both the natural world and us humans. We discuss just how noisy our modern world is, and visit a National Park in California to hear how they’re encouraging more peace and quiet there.Meanwhile Michelle, having witnessed her husband wince in pain at the sound of squeaking takeaway boxes, asks why certain noises are particularly unpleasant or even painful to some people.And finally, Jennifer has a sonic mystery for us to solve: why does the time of day make such a difference to the distant noises reaching her remote home?

An outbreak of pathogenic bird flu, H5N1, in a Spanish mink farm could be a cause for concern. Some experts fear the virus may now spill over to other mammals without strict surveillance. Marion Koopmans, professor of virology at Erasmus Medical Centre, talks Roland through the potential risks.India’s caste system affects all aspects of society, but how does the hierarchy influence representation of marginalised groups in academia? Science journalist Ankur Paliwal believes that, despite efforts to combat discrimination, not enough is being done, and he has the data to prove it.Imagine a robot... Is it hard, metallic and humanoid? Professor Carmel Majidi from Carnegie Mellon University and his colleagues are thinking outside the robotics box. Their new material, magnetic in nature, can shift between solid and liquid states. It’s even capable of breaking out of robotic jail...From Lawrence of Arabia to Star Wars via tales of intrepid adventurers traversing lonely sandswept landscapes, deserts have always had a powerful pull on the popular imagination.But if a desert is full of sand, where did all that sand come from in the first place? That’s what CrowdScience listener Andy wants to know, so presenter Caroline Steel heads off into the dunes to try and find out.Along the way she’ll be wondering what a desert is anyway and whether it’s always sandy, as well as tracing the flow of material across the huge, ever-shifting sand seas of the Sahara.From deserts fed by sand from mountains thousands of kilometres away, to dunes migrating across the entire continent of Africa, we’ll discover how sand has just the right properties to be carried along by the wind.We’ll also explore how the sand in every desert has a unique fingerprint, and find out how fish bones in the Sahara tell the story of its lush, green past.Image credit: Ole Jensen/Getty

Climate researcher, Rose Abramoff took to the stage at the American Geophysical Union (AGU) fall meetings, not as a guest speaker but in protest. Whilst her demonstration only lasted 15 seconds, she found her employment terminated from Oak Ridge National Laboratory and research stripped from the AGU programme. She was attempting to persuade other climate scientists to ‘get out of the lab and into the street’. Whilst Rose’s protest hit the headlines in the media, potentially less attention was paid to the session that was taking place at the conference, hosted by Mika Tosca, climate scientist-turn-artist, Associate Professor of Liberal Arts at the School of the Art Institute of Chicago. Ronald brings the two together to discuss the event and how climate scientists should approach activism.Although there is no one solution to the climate crisis, Roland loves a brainstorm on Science in Action. Climate activist Stuart Capstick, a Cardiff University psychologist specialising in public attitudes to environmental issues and environmental scientist Robert Young from Western Carolina University take the conversation one step further. Questioning how public perceptions of scientists change when they take evasive action and protest.And finally, we usually hear of seismology reports coming from dense, urban areas prone to earthquakes, delicately perched atop of tectonic plates. But this week, Roland speaks to Professor of Geophysics Zhongwen Zhan from the California Institute of Technology, who’s collecting data from a very unusual place...When CrowdScience listener Eric spotted a few gnats flying around on a milder day in mid-winter it really surprised him - Eric had assumed they just died out with the colder weather. It got him wondering where the insects had come from, how they had survived the previous cold snap and what the implications of climate change might be for insect over-wintering behaviour? So he asked CrowdScience to do some bug investigation.CrowdScience presenter Marnie Chesterton takes up the challenge and heads out into the British countryside – currently teeming with buzzes and eight legged tiny beasties - to learn about the quite amazing array of tactics these small creatures use to survive the arduous days of cold.She hears how some insects change their chemical structure to enhance their frost resistance whist others hanker down in warmer microclimates or rely on their community and food stocks to keep them warm.But cold isn’t the only climatic change insects have to endure, in the tropics the seasons tend to fluctuate more around wet and dry so what happens then? Marnie talks with a Kenyan aquatic insect expert who describes how mosquitoes utilise the rains and shares his worry climate change could have a big impact on insect populations.