Unexpected Elements

Remdesivir a drug eventually rejected as a treatment for Ebola seems to have aided recovery in a trial with more than a thousand Covid -19 patients. Researchers are cautious but hopeful; a leading health official in the US has made comparisons with the impact of game changing drugs used to treat HIV. In contrast an organisation researching the mechanisms by which bat coronaviruses infect humans has had its funding cut following criticism from President Trump.A scheme to help manufacture ventilators and protective equipment worldwide has seen some success with a simple ventilator they developed, now in use in hospitals.And we look at climate change –with this year set for extreme weatherWhat’s the importance of zero, and how was it discovered? How do scientists calculate Pi’s infinite digits? Why do so many people find maths difficult – and what’s the most difficult thing in maths?CrowdScience takes on a whole bunch of questions sent in by high school students in Spain. Like many children all over the world, their school is currently closed due to the coronavirus lockdown, but lessons continue at home. So how are their studies going, and can CrowdScience help out?We attempt to answer some of their trickiest maths questions with the help of mathematics whizz Katie Steckles, Pi aficionado Matt Parker, and mathematical biologist Kit Yates.Image Credit: Getty Images

President Trump has repeated unfounded claims that scientists created Covid-19 in a lab. Rigorous scrutiny of the genetics of the virus reveals no evidence for such a claim. And Brazil’s President Bolsonaro is at odds with his own health advisors – splitting public opinion and action over lockdown measures needed to control the virus. We also look at why Covid -19 seems to be associated with so many different symptoms, from diarrheal infections to complicating kidney disease, to heart attacks And some potentially good news from HIV research, a new target to stop that virus in its tracks, which might also be useful in the fight against other viruses.If you're an exercise fan, you'll know that sweating is how our bodies keep us cool, but how much water we lose and which bits of us get wettest depend on a whole host of factors. Jamaican listener Andre wants to know why he sweats in a heart-shape when he hits the gym, and we find out how everything from the clothes he wears to the moves he's doing explain his unusual perspiration patterns. In Kenya we meet a woman whose permanently clammy hands cause her to drop her mobile phone, and sweaty feet start to stink when she spends too long in shoes. Hyperhidrosis is a condition affecting millions of people worldwide but an expert explains some of the treatments for this mysterious condition.Image: President Trump (rhs) with Brazilian President Bolsonaro (lhs). (Photo by Alex Wong / Getty Images)

Italy is beginning its first tentative steps towards ending its lockdown. These are small steps, opening a few shops in areas where virus transmission has seen big falls. Part of the reason for this controlled strategy is that there are real concerns over a potential resurgence of the virus, Around the world there are now hundreds of trials on drug treatments for Covid 19. Results so far are mixed, with antivirals developed for Ebola and HIV showing positive signs, but antimalarial drugs, championed by President Trump in particular have been shown to have dangerous potentially life threatening side effects.A warning from history, more than 500 years ago suggests the western US in particular is entering an extreme drought, a ‘Megadrought’. When this last happened it led to war, depopulation and the spread of disease.And its 10 years since the Deepwater Horizon oil spill in the Gulf of Mexico. Studies of fish in the region suggest they are still affected by oil from that spill and more recent lesser known pollution events.If you have ever watched a spider as it works to build a web, spiralling inwards with a thread of silk, that intersects each glistening spoke with a precise touch of the foot, you will know that it is a remarkably complex behaviour. In this episode, presenter Geoff Marsh dives into the minds of spider-constructors as they build their webs. CrowdScience listener Daan asked us to find out how spiders can build webs without ever being taught how to do it. Are they just little robots controlled entirely by their genetic instructions? Spider silk expert Dr Beth Mortimer, describes the process of building a web in detail, while Professor Iain Couzin explains the simple modular behaviours that build up, in sequence, to create apparently complex instincts, like the huge locust swarms that are sweeping across vast areas of Africa and Arabia. Taking us deep under the exoskeletons of invertebrates, Professor Gene Robinson reveals an animal's behaviours can be altered by their genes, and the root similarity between learning and instincts. Spiders, despite their tiny size, have fascinating behaviours. Some jumping spiders can work out the best way out of a maze, and one arachnologist reveals how some social spiders can cooperate to build communal webs and capture moths that are many times their size. Geoff searches for the science that can reveal how instinct can create complex behaviour by setting up interviews at the homes of spider experts from around the world.(Image: Italy, shops begin to open. Credit: European Photopress Agency)

Massively over crowded Moria refugee camp on the Greek island of Lesbos has seen numbers grow from 5 to 20 thousand in a matter of months. Hundreds of people share taps and toilets, there is little chance to implement measures designed to stop the spread of covid 19. So far the camp has not been hit by the epidemic, but aid agencies fear for the most vulnerable in the camp. Covid 19 jumped from bats to humans, possibly via another wild animal. A study of zoonotic diseases has identified many other viruses that could do the same. The skies are clearer, levels of pollution from traffic have dropped by up to 50 percent but how long will cleaner air remain?And Comet Borisov makes a spectacular exit.Listener Keith from Lincolnshire wants to know how to reduce stress as he is under extreme pressure as a firefighter. Not only does he have to cope with the stress of responding to emergency situations but he has to do it while wearing challenging breathing equipment. We all experience times of stress, especially given the current situation, our chest starts to feel tight and our breathing becomes shallow. Claudia Hammond – presenter of BBC World Service programme Health Check – explains steps we can take to protect our mental health during this pandemic. How should we alter our breathing to manage stress? Presenter Anand Jagatia speaks to breathing experts to find techniques to help listener Keith, and everyone else.(Image: Moria refugee camp, Lesvos, Greece. Credit: Getty Images)

Nigeria has seen a small number of Covid -19 cases, largely spread amongst the most affluent, people who travel abroad, However there is concern about the potential of the virus to spread to overcrowded slum areas. In such conditions social distancing measures would be difficult to enforce. What are the alternatives? The US now has the majority of cases of the virus, New York has been heavily hit, medics have developed an app to help understand the spread of Covid 19 in the community. The availability of test kits is an issue worldwide, we look at a novel idea, adapting a device made from paper that could help to see whether the virus is present in wastewater.The WHO has launched international drug trials to tackle covid 19, but none of the drugs involved were developed specifically to target this virus we look at why they might just work. In medicine, it’s long been recognised that a placebo, a sham medicine or treatment, can have a powerful positive effect on a patient’s health. Part of that effect relies on a person’s belief that an inactive substance or treatment (for example, a sugar pill) is in fact an active drug. Placebos come in many forms and the scientific study of placebo is an active area of research. With this in mind, CrowdScience listener Nigel got in touch to ask if can placebos be used to improve sports performance? As an amateur sports enthusiast, he’s been reading up on his sports psychology to try and improve his game but he wonders if any coaches or psychologists use placebos to improve performance? Always ready to take up a challenge, presenter Anand Jagatia explores the world of endurance sport to find out how a placebo might used to improve athletes’ performances as well as his own and look at how advances in brain science are helping us understand the unusual neurobiology of placebo. And what of the amateur golfer or rugby or table tennis player - can placebo help? On an individual level, so called ‘verbal placebo’ is a technique that can help players with anxiety, confidence and concentration, and ultimately make them win more. And what about team sports – when, say, a new manager takes over at an ailing football club, and sparks a massive reversal in poor results, is that placebo effect in action? The CrowdScience team investigates.(Image: Getty Images)

The strong social distancing policies introduced by China seem to have been successful in stopping the spread of Covid 19. Without any effective drug treatments, reducing our number of contacts is the most effective way to prevent viral transmission.We also look at the similarities been policies in Russia and the US on how best to deal with the virus. In both cases there are contradictions and disagreements between medical professionals and politicians.And a warning from Polio, how vaccines may create problems when immunisation campaigns do not reach everyone.And If you've ever felt the urge to shop till you drop, then you may already know about some of the clever ways retailers convince us to consume. From flash sales to so-called unbelievable offers, there are a whole range of techniques aimed at encouraging us to flash the cash. Listener Mo works in marketing, so knows more than most about the tricks of the trade - but he wants CrowdScience to investigate how neuroscience is being used to measure our behaviour and predict what we’ll buy. Marnie Chesterton finds out how brain scans are being used to discover which specific aspect of an advertisement a person is responding to, and then she hears how this information is being used by companies who want to sell us more stuff. But there's also evidence to suggest we have less control over these decisions than we think, and that computers are getting closer to detecting our intention before we're even aware of it ourselves. And this could have huge implications for the way we shop.(Image: Getty Images)

In Italy the entire population of a small town was tested for Covid 19. Of those infected, one in three people with no symptoms had the virus. And from China researchers found many people carried the virus – even before authorities there began tracking its spread. The findings suggest vulnerable people may contract the virus from those without symptoms.And we’ve news of a breakthrough - new tests looking at Covid 19 antibodies, These should help provide a picture of developing immunity to the virus.However as growing numbers of people fall ill there are concerns over a potential shortage of hospital ventilators globally, These are needed to treat the most severe cases. However a crowdsourcing project has been set up to try and kick start the manufacturing of a variety of different types of ventilator that could be built around the world. If you have knowledge of ventilators or their use and would like to get involved more information is available here. http://bit.ly/frontiertech4COVIDactionMany of us are fascinated by our ancestry: knowing where our families came from can give us a sense of identity and roots. Tracing your family tree is a time-honoured tradition, but several companies now sell DNA tests that offer you insights into your heritage: so you might find out you’re 70% Nigerian, 39% Italian, or 11% South Asian, for example.There’s no doubt that genes contain clues about your family history, but how reliable are these commercial tests? That’s what CrowdScience listener Karen wondered after an update of her test results showed her going from 39% Scandinavian to 2% Norwegian. How confident can she be in her results now? And what does it actually mean to be 2% Norwegian, in terms of your family tree?Presenter Alex Lathbridge delves into his own African and European ancestry, talks to some of the companies offering these tests, and unpicks the complex relationship between genetic science and family trees. We meet a woman who found her long-lost uncle with a combination of a DNA test and old-fashioned archive research; and look to the Americas to ask whether genetic testing can restore ancestral ties erased by the inhumanity of the transatlantic slave trade.(Image: AFP/Getty Images)

Covid- 19 cases seem to be multiplying daily and there is now a growing body of scientific evidence both on its spread and the effectiveness of measures to try and control it. We look at what’s working, what’s not and why. And we look to the potential for coronavirus drug treatments, why despite the hype there really isn’t anything round the corner.Australia’s recent fire season was intense; a new study looks back over 500 years of the weather pattern partly responsible, the Indian Ocean Dipole. The findings show the most extreme years occurred recently – under the influence of man-made climate change. And we look at life deep below the sea floor, microbes which multiply slowly over centuries and eat their neighbours. Since the outbreak of a new strain of coronavirus late last year, health workers and governments have been rushing to limit transmission by deploying containment tactics and anti-contamination campaigns. But, as the virus spreads around the world, what are scientists doing to help our bodies fight off or resist this new infectious disease?Viruses that cause human disease can be notoriously tricky to tackle. They don’t respond to antibiotics, can spread rapidly between human hosts, and even evolve improved ways of working as they multiply. Presenter Marnie Chesterton heads to the University of Oxford’s Nuffield Department of Medicine to meet the researchers who are urgently searching for solutions. Professor Tao Dong is Director of Chinese Academy of Medical Sciences Oxford Institute, collaborating with colleagues on the ground in China to see how Chinese patients’ immune systems are responding to the virus, which could inform vaccine design. Professor Sarah Gilbert leads the Jenner Institute’s influenza vaccine and emerging pathogens programme. She’s been developing a vaccine against another strain of coronavirus that caused the Middle East Respiratory Syndrome (MERS) outbreak, and is using the same technology to generate a new vaccine against the 2019 coronavirus. And, whilst that’s being developed, there is a possibility that some existing antiviral drugs may even help infected patients – Professor Peter Horby is working with colleagues in China on clinical trials to see what might work. CrowdScience goes into the laboratories using cutting edge science to combat coronavirus. (Image: Coronavirus test. Credit: iStock / Getty Images Plus)

Attributing Australia's bush fires, a major study says man-made climate change was a big driver – making the fires at least 30% worse than they would have been if natural processes were the only factors.We look at preparations for coronavirus in Africa. Although cases there are currently lower than in much of the rest of the world a major training initiative is taking place to spread awareness amongst medics across the continent.We ask why Horseshoe bats in particular carry coronaviruses, and find a novel idea for distributing vaccines in places without refrigeration.And why are we obsessed with crime? Kay from Hamburg, Germany asks as every Sunday evening Germans pile into their local pubs to watch Tatort, a hugely successful crime drama which has been running for 50 years.Presenter Marnie Chesterton starts with the science and speaks with psychologists to get to the bottom of where this obsession might come from. Have we evolved to have an innate obsession with danger or are we addicted to feeling fear?Or perhaps the dramatisation of crime fuels our obsession. Producer Caroline Steel visits the film set of BBC crime drama, Line of Duty. Producer Jed Mercurio explains what draws us to crime narratives and the techniques he uses to keep his audience captivated. But does the way we chose to represent crime in media match up with reality? And what is the impact of this on society and policy?(Image: Australian bushfires. Credit: Getty images/AFP)

The appearance of Covid -19 in Italy and Iran surprised many this week. As the virus continues to spread we look at ways to contain it.Australia’s fires have burnt around 20 percent of the countries woodlands, what are the implications for the recovery of those ecosystems?And what is the link between the world’s super rich and deforestation? Unsurprisingly it’s money.And we hear about the unexpected cooling effects of hydroelectric dams.Weather: wet, dry, cold, hot, sunny, windy or downright weird - there’s nothing quite like it as a conversation starter, from Austin to Jakarta. And judging from the large volume of emails about all things meteorological in the CrowdScience inbox, there’s plenty to talk about. What’s the weirdest weather on Earth, and how big a chance is there of it happening? Why does it always seem to rain on the days when we’re not working? And – conversely – is there any way we could make it rain when and where we need it to? Presenter Anand Jagatia finds out the answers to these questions and more by bringing together a panel of experts under the CrowdScience umbrella: Prof Liz Bentley, Royal Meteorological Society; Dr Anthony Rea, World Meteorological Organization, and Dr Rebecca Buccholz, National Centre for Atmospheric Research.(Image: Tourists wearing masks tour outside the Coliseum in Rome. Credit: Getty Images)