This week — a new technology falls into the wrong hands.Pope Brock's book, CharlatanPenny Lane's documentary, Nuts! Learn more about your ad choices. Visit podcastchoices.com/adchoices

For years, Dr. Richard Bedlack has hunted for a cure for ALS, a fatal degenerative disease. And then one day he builds a website called ALS Untangled. That's when strange things start to happen. Reported by Peter Andrey Smith and Reply All producer Sruthi Pinnamaneni.Further ReadingThe ALS Untangled websiteDr. Richard Bedlack’s ALS Reversals websiteThe PatientsLikeMe websiteThe ALS TDI websiteNelda Buss wrote a book, You Can Walk, about her experience, and she originally appeared on Fox in 1992Eric Valor’s website Angelina Fanous’s reporting on VICE and The New York TimesPeter Andrey Smith’s website Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week, updates on some of the stories we’ve done over the past year, some bonuses and surprises, some breakbeats, a motorcycle ride, and we take a glimpse into the future.Check out the amazing 2016 Reply All poster by Matt Lubchansky!The Episodes#56 Zardulu#64-67 On the Inside Parts I-IV#53 In the Desert#68 Vampire Rules#57 Milk Wanted#47 Quit Already!Lightning Round#76 Lost in a Cab#83 Voyage Into Pizzagate#60 A Simple Plan#61 Baby King#69 Disappeared#78 Very Quickly to the DrillFurther ReadingIllustrator Matt Lubchansky’s website is OVER HERESinger/songwriter Matt Farley can be found on his website or on Spotify.Our theme song is by the Mysterious Breakmaster Cylinder.Our ad music is by Build Buildings. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Everybody has that one Facebook friend who just won’t stop posting their political opinions. This week, we talk to one of those Facebook friends, someone whose opinions got her into an enormous mess. Learn more about your ad choices. Visit podcastchoices.com/adchoices

A conspiracy theory, a pizza related map, and a website fighting for its very soul.Further ReadingBryan Menegus' great article, "Reddit is Tearing Itself Apart."An interview with Edgar Welch, the Pizzagate gunman.The Donald SubredditIf you have a question about a story we've reported this year, please email a voice memo of 30 seconds or less to replyall@gimletmedia.com with the subject line "updates." Learn more about your ad choices. Visit podcastchoices.com/adchoices

Alex and PJ take calls from anyone, about anything, for 48 hours straight.Thank YousAdam Quinn (for setting up our phone system)Peter Nelson (for his excellent horn playing)The Mysterious Breakmaster Cylinder (for going above and beyond this week)Matt FarleyJorge JustAustin ThompsonBuild BuildingsEveryone who called Learn more about your ad choices. Visit podcastchoices.com/adchoices

One man tries to unite America. One Frog threatens to tear it apart. Learn more about your ad choices. Visit podcastchoices.com/adchoices

This week: a bitter Yes Yes No rivalry, and the return of 10 Minutes on Craigslist. Someone has gone missing.Further ReadingThe original tweet.Loss. Learn more about your ad choices. Visit podcastchoices.com/adchoices

Thomas Oscar is an Australian teenager who tried to make the most boring Facebook group possible - a group where members pretend to be corporate drones in a non-existent office.The FactsKaren Duffin is a producer at This American Life. You can find more stories by Karen Duffin at her website.Our theme song is by the mysterious Breakmaster Cylinder.Our ad music is by Build Buildings.Further ReadingYou can check out the Stackswell and Co. Facebook page here.Read a story about Stackswell and Co. from Fast Company here. Learn more about your ad choices. Visit podcastchoices.com/adchoices

To reach a port, we must set sail. Learn more about your ad choices. Visit podcastchoices.com/adchoices