Discovery

Alana Saarinen, a 13-year-old with DNA from three people, raises questions about children born this way as the UK considers legalizing mitochondrial replacement. The podcast delves into the safety, health implications, and ethical debates surrounding this groundbreaking genetic technology.

Infectious bacteria are becoming resistant to the drugs that used to kill them. The last new class of antibiotics was discovered in the 1980s. There is little in the development pipelines of the world’s pharmaceutical industry. Drug companies got out of antibiotics as their attention switched to much more lucrative daily medicines for chronic diseases. Public funding on antibiotic research has also withered. Now that the gathering crisis of antibiotic resistance is becoming recognised by politicians, what are the options? Roland Pease explores how business, academia and governments might work together to avert a return to the medical dark ages.Image Credit: Hospital scientist inspects an unidentified culture in the Microbiology Department of Sydney's Royal North Shore Hospital, Greg Wood/AFP/Getty Images

The discovery and harnessing of antibiotic drugs in the mid-20th Century led some medics to predict the end of infectious diseases. But the bacteria fought and continue to fight back, evolving resistance to many of the drugs that used to kill them. Public health officials warn that without new drugs, medicine will return to the days where ‘a cut finger on Monday leads to death of Friday’. Without protective antibiotics to keep infections at bay, scores of standard surgical operations and chemotherapy for cancer will become too risky.Roland Pease looks at scientific issues behind the gathering crisis. The last new class of antibiotics was discovered in the 1980s. Are there any others in the pipeline?Image Credit: Hospital scientist inspects an unidentified culture in the Microbiology Department of Sydney's Royal North Shore Hospital, Greg Wood/AFP/Getty Images

In March astronomers in the BICEP2 collaboration announced they had found gravitational waves from the Big Bang. But now the evidence is being questioned by other scientists. Dr Lucie Green reports on the debate and asks if scientists can ever know what happened billions of years ago when the universe was formed.Image copyright: Steffen Richter, Harvard University

On 6th August, the space probe Rosetta ends its 10 year journey and arrives at Comet 67P/Churyumov-Gerasimenko. If all goes well, Rosetta will be the first spacecraft to go into orbit around a comet. The European Space Agency probe will then accompany the comet until December 2015, studying the 4 kilometre-wide lump of ice and rock dust at a level of detail far surpassing any previous comet flyby.In the words of Rosetta scientist Joel Parker, “Previous comet missions have been one-night stands, Rosetta will be there for a long term relationship.” Rosetta will stay with 67P as it heads towards and around the other side of the Sun. Rosetta will be watching everything at close quarters as the comet heats up and produces the classic gas and dust comet tail.In the final weeks of approach, the Rosetta team have realised this is going to be an even more interesting mission than they had supposed. In the middle of July, the probe’s camera revealed the bizzare shape of the comet’s nucleus. It appears to be formed of two objects joined together. Some have described it as having the shape of a toy duck. In November, Rosetta will send a small robot lander, Philae, down onto the comet’s surface – another hugely ambitious feat, given the feeble gravitational pull of the comet and its complex shape. Philae could bounce off into the void if its trajectory is not quite true and its on-board harpoons fail to secure it to the comet’s icy surface. Discovery looks ahead to the mission’s key moments and big science questions with planetary scientists and members of the Rosetta science team: Professor Ian Wright - principal investigator (PI) for the lander’s Ptolemy instrument, Professor Monica Grady - planetary scientist at the Open University, UK. Matt Taylor, project scientist on Rosetta Dr Joel Parker - deputy PI for Rosetta’s Alice spectrometer Dr Holger Sierks - principal investigator for Rosetta’s Osiris camera Dr Stephan Ulamec - project scientist for the lander Philae (German Space Agency) The big questions for Rosetta include: did comets bring water and the essential ingredients for life to the early Earth?Presented and produced by Andrew Luck-Baker Image Credit: Rosetta and Philae at Comet, European Space Agency

Professor Sir Michael Rutter has been described as the most illustrious and influential psychiatric scientist of his generation. His international reputation has been achieved despite the fact that as a young doctor, he had no intention of becoming a researcher, nor interest in becoming a child psychiatrist. In fact he became a world leader as both. His career has spanned more than five decades and is marked by a remarkable body of high-impact research and landmark studies. The theme running through all his work has been child development, on the subtle interplay between nature and nurture and on the factors that make the difference between a child flourishing, or floundering. Evacuated during World War Two, to a Quaker family in the USA, Mike Rutter tells Jim al-Khalili about the impact this move, aged seven, had on him. He describes the inspirational teachers who persuaded him that research and clinical work as a child and adolescent psychiatrist, was for him, and he admits that an early mentor insisted he mustn't receive any formal training in child psychiatry, something he hasn't received to this day! He was awarded this country's first ever professorship in child psychiatry in 1973 and he's credited with founding the field of developmental psychopathology. This involves the study, over time, of normal and abnormal child development. He's currently Professor of Developmental Psychopathology at King's College, London and still a practicing child psychiatrist. An early breakthrough was his discovery that autism, or inifantile psychosis as it was then known, had a genetic basis, something barely suspected at the time. Beautifully designed studies of populations over time followed, many of them landmark studies still cited today. They established the framework for studying and investigating mental illness in the community. The Isle of Wight Studies (1964-74) surveyed the mental health of children living on the island and for the first time in such research, children themselves were directly interviewed and questioned. Before this, Mike Rutter tells Jim, the assumption had been that what children thought and said didn't really matter. In the 1970s, the Fifteen Thousand Hours study, delivered ground-breaking evidence about the combination of factors that affected the performance and behaviour of children in inner city secondary schools. Findings from this study were included by both the Labour and Conservative parties in their 1979 election manifestos. "Maternal Deprivation Reassessed" was Mike Rutter's challenge to John Bowlby's hugely influential theory of maternal attachment. It was described as "a classic in the field of childcare" and it transformed the debate about the relationships that help babies to flourish. His fascination with the underlying reasons why and how children vary in their ability to weather and cope with adversity, led to the growth of resilience science. For more than 40 years Mike Rutter, "the intellectual father", has led this field of study. His name is particularly associated with "natural experiments" and one of the best known is the English Romanian Adoptees study that he set up in the early 1990s and still runs today. The children being followed are those rescued from the orphanages of Nicolai Ceausescu and adopted by families in this country. Because of the appalling conditions many of these babies and toddlers experienced in Romanian institutions, Professor Rutter understood that tracking and studying them as they grew up in loving homes here, would provide important insights into how early deprivation affects childrens' development. Producer: Fiona HillImage: Professor Sir Michael Rutter, BBC Copyright

At the start of 2014 meteorologists warned of a possible El Nino event this year. The portents were persuasive – a warming of the central Pacific much like that which preceded the powerful El Nino event of 1997. But since then the Pacific climate system seems to have stalled. What’s going on? What are the prospects for an El Nino to develop later this year? What impacts might it have? Roland Pease delves below the Pacific surface to find out what drives El Nino cycles, the most powerful single climate fluctuation on the planet, and asks the experts why it is so hard to forecast. “The year started with a bang,” one expert tells Discovery - will it end with a whimper?(Photo: Burned swamp forest in Kalimantan. Credit: Florian Siegert, RSS GmbH)

Adam Hart looks at how new developments in understanding insect behaviour, plant cell growth and sub cellular organisation are influencing research into developing robot swarms. Biological systems have evolved elegant ways for large numbers of autonomous agents to govern themselves. Staggering colonies built by ants and termites emerge from a decentralized, self-governing system: swarm intelligence. Now, taking inspiration from termites, marine animals and even plants, European researchers are developing autonomous robot swarms, setting them increasingly difficult challenges, such as navigating a maze, searching for an object or surveying an area. At the same time, an American team has announced that its group of robots can autonomously build towers, castles and even a pyramid. Adam Hart reports on the latest developments in controlling groups of robots, and asks why models taken from the behaviour of social insects such as bees, ants and termites may be far more complex than previously thought. He also delves deep into the cells of plants looking at how the physical and chemical triggers for plant growth might be useful in robot design.Image: Presenter Adam Hart with ‘Swarmbots’ at Britain’s Surrey University, BBC Copyright

General anaesthetics which act to cause reversible loss of consciousness have been used clinically for over 150 years. Yet scientists are only now really understanding how these drugs act on the brain and the body to stop us feeling pain. Linda Geddes reports on the latest research using molecular techniques and brain scanners. Linda visits the Anaesthesia Heritage Centre where William Harrop-Griffiths, president of the Association of Anaesthetists of Great Britain and Ireland, tells her about the discovery of agents that knock us out. And, as an operation takes place in the Royal United Hospital in Bath, professor Tim Cook explains the role of the anaesthetist. Linda also talks to professor Nick Franks of Imperial College, London, about his research into how anaesthetics work at the level of the cell. Irene Tracey, professor of Anaesthetic Science at Oxford University, discusses how her fMRI scans of people as they slowly undergo anaesthesia have revealed how the brain switches off. Professor Steven Laureys, head of the Coma Science Group at Liege Universiy in Belgium, explains how understanding anaesthesia can help coma patients and what it tells us about the difficult question of human consciousness.

Janet Hemingway, the youngest woman to ever to become a full professor in the UK, talks about her career at the frontline of the war on malaria. Whilst many researchers look for vaccines and treatments to this global killer, Janet's approach, as a trained entomologist, has been to fight the mosquito - the vector - which transmits the malaria parasite.Image: Janet Hemingway, BBC Copyright