Discovery

Ijeoma Uchegbu, a Professor of Pharmaceutical Nanoscience at University College London, is revolutionizing drug delivery with nanoparticles that target hard-to-reach areas in the body. She shares her inspiring journey from being a foster child to a single mom pursuing a PhD. Ijeoma's groundbreaking research aims to treat conditions like blindness with innovative eyedrops. Passionate about equity in science, she also discusses her role in promoting diversity and her unique approach of using stand-up comedy to make complex science accessible.

Darren Croft studies one of the ocean’s most charismatic and spectacular animals – the killer whale. Orca are probably best known for their predatory behaviour: ganging up to catch hapless seals or attack other whales. But for the last fifteen years, Darren Croft’s focus has been on a gentler aspect of killer whale existence: their family and reproductive lives . Killer whales live in multi-generational family groups. Each family is led by an old matriarch, often well into her 80s. The rest of the group are her daughters and sons, and grand-children. Especially intriguing to Darren is that female orca go through something like the menopause - an extremely rare phenomenon in the animal kingdom, only documented in just five species of toothed whales and of course in humans. Halting female reproduction in midlife is an evolutionary mystery, but it is one which Darren Croft argues can be explained by studying killer whales. Darren is Professor of Animal Behaviour at the University of Exeter. He talks to Jim Al-Kalili about his research on killer whales, his previous work revealing sophisticated social behaviour in fish, his life on the farm, and the downsides and upsides of being dyslexic.

Bill Gates is one of the world's best-known billionaires - but after years at the corporate coalface building a software empire and a vast fortune, his priority now is giving that wealth away. And his ethos for doing it has been shaped by science.Famed for co-founding Microsoft, in recent decades Bill’s attention has turned to philanthropy via The Gates Foundation: one of the largest charities in the world. Since its inception in 2000, the organisation has helped tackle issues around health, education, inequality and climate change in some of the world’s poorest countries, with an undeniable impact, from contributing to the eradication of wild poliovirus in Africa, to helping halve global child mortality rates within 25 years.But, as Jim al-Khalili discovers, for a man with lofty ambitions and an even loftier bank balance Bill has surprisingly humble tastes.

A small, informal survey leads to shocking revelations about the US justice system, with its truths only uncovered decades later. Meanwhile, an ambitious portfolio manager discovers a perfect graph outlining eye-watering profits. But something does not seem right. Could the graph be accurate, or is it hiding a far more sinister truth? This story delves into the power of data, the hidden forces behind it, and the unexpected revelations that can change everything

At a conference in Mexico, one scientist’s outburst sparks a global quest to find a ‘golden spike’ - the boundary marking the shift into a new geological period dominated by humans, not volcanoes or asteroids. From plastics and concrete to nuclear fallout, the data they uncover reveals a planet profoundly altered. But can they convince their colleagues and the world of the extent of this transformation? Meanwhile, in a small Italian city nestled in the Apennine mountains, a series of low-level tremors raise the question: Is this just a passing phase, or a warning of something much more devastating?

A PhD student with a passion for whales stumbles upon a strange, eerie sound deep beneath the ocean waves, something that will soon rock her world. Meanwhile, a fisherman is stranded in the ocean late at night, completely alone. With time running out, can he be rescued before it is too late? From mysterious discoveries to life-or-death struggles, this story delves into the power of the ocean and the determination to survive.

Amid the desperation of war-starved Netherlands, a doctor defies conventional wisdom to save gravely ill children, uncovering a treatment that sparks both hope and controversy. Years later, in 1967, a young female researcher detects a strange, pulsing signal. Could it be mundane interference or evidence of alien life? From lifesaving breakthroughs to cosmic discoveries, this story celebrates the determination of pioneers who challenge convention and pursue truth against the odds.

A mathematician searching for love discovers that relationships aren’t always as simple as equations—are his calculations the issue, or is there something deeper at play? Meanwhile, at an engineering conference, a young researcher’s seemingly minor mistake uncovers a scandal of epic proportions. Can numbers find love or unveil problems? From personal dilemmas to professional revelations, this episode dives into the unexpected ways numbers can change lives.

In 2016, Niall McCann was left with a bruised spinal cord when he crashed his speed glider into the side of a mountain at 50mph.He shares his journey to recovery and some unexpected life lessons he has had to navigate, from soiling himself in inconvenient places and not being able to control his flatulence, to having to re-learn how to have sex again.We also hear from a Mountain Rescue medic on what looked like an “unsurvivable” situation and Niall’s surgeon on fixing his “exploded” spine.

Perhaps you couldn't drift off, or maybe you woke in the middle of the night and then couldn't nod off again. In this edition of Inside Health we're talking all about insomnia. It’s an issue that may affect many of us at some point in our lives – but for some it goes beyond a short period of not being able to sleep and becomes something more serious. James is joined by a trio of experts ready to answer to them: Dr Allie Hare, president of the British Sleep Society and consultant physician in sleep medicine at the Royal Brompton Hospital, Colin Espie, a professor of sleep medicine at Oxford University and Dr Faith Orchard, a lecturer in psychology at Sussex University. We’re going to find out why we get insomnia, when to seek help and how much factors like ageing, menopause, needing the loo or shift work matter. And we'll look at the latest advice and treatments. Can insomnia be fixed?