BBC Inside Science

BBC Radio 4
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Feb 8, 2018 • 29min

Democracy in Space

This week a US based billionaire launched a giant space rocket and sent a car vaguely in the direction of Mars. As a space mission it was to say the least unconventional, and for those involved in promoting space science it presents a quandary. Is such a mission largely a publicity stunt or is it useful for engaging people in the potential of space exploration? Gareth Mitchell looks at one project which enables schoolchildren to programme computers on the International Space Station and he talks to the European Space Agency about why a rock concert might be a good avenue for exploring space science. As more and more of our everyday lives are conducted online we ask what are the cyber-security threats of today, and how can science be used to counter them. Do we now need new kinds of science to locate, understand and stop new kinds of threat? Can bat science help human ageing research? New findings have show that some long lived bat species do not age in the same way as other mammals. They don't even seem to posses the DNA repair enzyme most commonly found in the animal kingdom. We look at the mystery of why bats seem to have evolved in this way.And have you lost a satellite? Don't worry: a computer geek will find it for you. That's exactly what's happened - an amateur space sleuth has detected signals from a NASA satellite thought to have been 'lost' for years.
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Feb 1, 2018 • 33min

Scientists on Trial

In 2016 there was an attempted coup in Turkey. This led to many people who the government saw as opposition figures being sacked from their jobs and in some cases held without trial. They include prominent intellectuals, medics and scientists. In recent days there has been a similar crackdown on people voicing criticism of Turkey's current military actions in Syria. Stephen Reichter, Professor of Psychology at St Andrews University has been to Turkey to observe the trial of one of his former colleagues. He tells us what he saw and discusses the wider issues for science.It's the 60 years since the launch of Explorer 1 and the discovery of the Van Allen Belts. This was the satellite the US launched in response to Sputnik. However unlike Sputnik it did undertake scientific exploration, its findings have been significant for every space mission that followed.Using DNA sequencing scientists have found that the 'Two Brothers' mummies at the Manchester Museum have different fathers so are, in fact, half-brothers. Khnum-nakht and Nakht-ankh - date to around 1800 BC. Ever since their discovery in 1907 there has been some debate amongst Egyptologists on whether the two were actually related at all. DNA was extracted from their teeth to solve the mystery.And the science of the Archers, a current storyline involves leaks of industrial chemicals illegally buried on a farm many years ago. We'll be looking behind the scenes to see where the story came from and how the world's longest running soap opera ensures scientific accuracy.This week's programme is presented by Gareth Mitchell as Adam is away.
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Jan 25, 2018 • 29min

Did typhoid kill the Aztecs, DNA stored in Bitcoin, Glow-in-the-dark plants and levitating humans

What killed the Aztecs? In some areas of the Americas, as many as 95% of the indigenous population died of diseases brought in by the discoverers of the New World. Pandemics hit the population who had little immunity to diseases carried by people and livestock. One outbreak responsible for killing millions started in 1545 and was locally called 'cocoliztli'. But for the last 500 years, exactly what this deadly disease was has remained a mystery. Adam talks to Johannes Krause of the Max Planck Institute who has analysed the teeth of 10 individuals from a mass grave for pathogens and found remnants of typhoid fever DNA. Could this be, in part, responsible for the deaths of millions? Historian Caroline Dodds Pennock from the University of Sheffield discusses the difficulties of knowing for definite what killed so many millions of people. In 2015, Nick Goldman issued a challenge. If anyone could decode the information he had stored on some DNA by 21st January 2018, they could win a bitcoin. When Nick bought the bitcoin it cost about £200. To claim the bitcoin, the winner would have to sequence the DNA and then decrypt a code. In late 2017, Nick thought he would be keeping his bitcoin, now worth thousands of pounds. But PhD student Sander Wuyts got in touch with Nick to claim his prize. Marnie Chesterton follows the story. Adam talks to MIT scientist, Michael Strano about his new techniques to make plants glow in the dark. Could these plants be used as street lighting in the future? And how can sound be used to levitate humans? Professor of Ultrasonics at the University of Bristol, Bruce Drinkwater explains how his team have managed to overcome a size limit on the use of acoustic beams to trap and move objects in space. With no theoretical upper limit on the size of object which can be levitated, he explains how the technology could be used in medicine to deliver powerful drugs to a very specific place. This would leave the rest of the body unharmed or could help in the dispersal of kidney stones.
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Jan 18, 2018 • 28min

African swine fever, Oil spill update, CRISPR gene editing, Rat eradication in New Zealand, Chimp kin recognition

African Swine fever is deadly to pigs and is spreading west from Russia across Europe. The virus that causes it is very resilient and can stick around on clothing, hay and in infected pork products for as long as 150 days. Biosecurity is crucial to preventing its arrival in the UK. If just one pig eats some infected meat from discarded human food the disease could quickly spread causing thousands of pigs to be culled and costing the industry millions. But what is the current progress on developing a vaccine? Adam talks to virologist Professor Jonathan Ball of Nottingham University and Zoe Davies from the National Pig Association. Simon Boxall from Southampton Oceanography Centre gives an update on the sinking of the oil tanker Sanchi and its environmental impact. CRISPR is a revolutionary gene editing technique which can modify DNA and has the potential to correct genetic errors in a range of human diseases - even cancer. The technique has only been around for a few years but is already being talked about as a Nobel prize winning candidate. The market for the technology has been predicted to be worth US$ 10 billion by 2025. But stocks took a wobble last week on news that our immune system may render CRISPR useless. Is there really a big problem? Adam talks to Matt Porteus from Stanford University who did the research. 18 months ago, New Zealand announced a conservation project to exterminate all vermin that are decimating the indigenous bird population. For millions of years, the flora and fauna evolved in isolation, without predatory mammals. When humans arrived, they brought with them a host of bird-eating animals like rats, stoats and possums which now kill 25 million native birds every year. Marnie Chesterton travelled to New Zealand to report on a campaign of mass poisoning to save the kiwis and the kakapos and asks whether it’s ethical to kill one species to save another. And Cat Hobaiter from St Andrews University responds to listener questions about how chimpanzees might recognise family members.
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Jan 11, 2018 • 28min

Sanchi oil tanker, Gut gas-monitoring pill and Chimpanzee portraits

After the Sanchi oil tanker collided with another ship it discharged its cargo of 1 million barrels of condensate oil. This could cause one of the biggest oil disasters in 25 years. What is condensate, can it be cleaned up and how toxic to marine life is it if large amounts of it leak or the tanker sinks? Adam talks to Simon Boxall from Southampton Oceanography Centre. A long-held belief that babies look more like their fathers is being put to the test by scientists at St Andrews University. They are launching an on-line citizen science experiment asking members of the public to see if they can tell from a group of chimps which are the close relations. Geoff Marsh takes the test and talks to researcher Cat Hobaiter about why it might be advantageous for a baby primate to look like its father more than its mother and what they hope to learn from humans' ability to recognise chimp family trees. A new swallow-able, electronic pill that sniffs out the gas produced in your gut could be the answer to accurately diagnosing and distinguishing between ailments of the gut. The gastrointestinal tract is hard to access so when something goes wrong, conditions like Irritable Bowel Syndrome, lactose intolerance and over production of bacteria. can be hard to distinguish from one another and so accurately diagnosed. Professor Kourosh Kalantar Zadeh from RMIT in Melbourne explains why his device, which senses gases in the gut and transmits its findings back to a smartphone in real time,, is more accurate and less invasive than current breath tests or endoscopies and colonoscopies. And Janet Kelso answers listener questions on human evolution and why modern Europeans still carry Neanderthal DNA.
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Jan 4, 2018 • 33min

Tabby's Star, Space 2018, Mosquito sounds, C diff and food additive link

Adam Rutherford talks to astronomer Tabetha Boyajian at Louisiana State University about the wierd star that's perplexed astronomers since its discovery two years ago. KIC 8462852 has the unique habit of intermittently and sometimes dramatically dimming and then brightening. Some scientists even suggested vast alien megastructures around the star might be the explanation. After twenty months of almost continuous observation, Professor Boyajian has much more information about what the star is doing. But the big mystery hasn't gone away.BBC News science correspondent Jonathan Amos joins Adam to share some highlights in space exploration for the coming 12 months.Zoologists and engineers at the University of Oxford are developing an app that identifies one species of mosquito from another by analysing the sounds their rapid wing beats make. Graihagh Jackson visits Marianne Sinka at the Zoology Department to listen to her collection of mosquito songs.Did the widespread introduction of the food additive trehalose fuel the emergence of epidemics of virulent Clostridium difficile in hospitals from the early 2000s? Microbiologist Robert Britton tells Adam about the evidence his team has gathered and published this week in the journal 'Nature'.
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Dec 28, 2017 • 34min

Ancient DNA and Human Evolution

Twenty years ago, a revolution in the study of human evolution began. A team in Leipzig in Germany successfully extracted DNA from the bones of a Neanderthal man who died about 40,000 years ago. Thirteen years later, the same group unveiled the first complete genome sequence of another Neanderthal individual. Last year, they announced they'd retrieved DNA from much oldest archaic human bones, more than 400,000 years old.Adam Rutherford talks to Svante Paabo, the scientist has led these remarkable achievements. Professor Paabo and his colleague Janet Kelso at the Max Planck Institute of Biological Anthropology in Leipzig discuss the genes in many European people alive today that originated in Neanderthals and were passed to modern humans when the two species interbred. Adam also speaks to Johannes Krause who worked on the Neanderthal genome project in Leipzig but is now director of the Max Planck Institute of the Science of Human History. His latest research adds a new layer of intrigue and complexity to the relationship between our species and Neanderthals in deep time. David Reich at Harvard University focuses on using ancient DNA to uncover the ancestry and movements of modern human hunter-gatherers in Eurasia from about 50,000 years to the Bronze Age, a few thousand years ago. Population movements occur on a cinematic scale, he says. (Podcast only).The revelations of ancient genetics would not be possible and meaningful without the traditional disciplines of palaeoanthropology and archaeology. Adam goes to Gibraltar to seek the perspective of Clive Finlayson who leads excavations there as director of the Gibraltar Museum. Gibraltar is the most concentrated site of Neanderthal occupation in the world. As well as remains of a young Neanderthal child last year, the Rock's caves have also recently yielded the first example of Neanderthal cave art.
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Dec 21, 2017 • 29min

Antisense RNA therapy, Fossils vs Trump, Printing mini-kidneys, Electric eel power

Promising results from a small clinical trial of Huntingdon's disease patients have led to RNA-directed therapy such as antisense RNA being hailed as possibly a turning point in the treatment of neurodegenerative diseases. Adam Rutherford discusses this class of drugs with Heidi Ledford of Nature News.At the beginning of the month, Donald Trump decreed that two national monument landscapes be drastically down-sized. Strict protections against exploitation were removed from vast tracts of land bearing some of the world's most important fossil bearing strata. President of the Society of Vertebrate Paleontologists, Professor David Polly explains why his organisation is now suing Trump.At Harvard University, bioengineers are growing parts of functioning kidneys in small chips using a form of 3D printing. Jennifer Lewis' lab is doing this to learn how kidneys function and explore the possible therapeutic applications of the mini-kidneys-in-a-chip. Roland Pease visits the team at work.The electric eel can deliver a 600 volt shock, from a stack of electrically charged cells along the length of its body. Inspired by the eel's biology, Michael Mayer and his colleagues at the Universities of Fribourg and Michigan have now created their own version of its electric organ with the help of jelly babies and clever origami. In the future, it could power devices in the human body.
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Dec 14, 2017 • 35min

The Future of Coral Reefs, Little Foot, Arthur C Clarke

Oxford is hosting the European Coral Reef Symposium this week. Climate change is seen as the number one threat to the future of coral reefs. Adam talks to Morgan Pratchett of James Cook University about the two recent coral bleaching events that hit the Great Barrier Reef, and to Barbara Brown of Newcastle University about the potential for coral species to adapt to warmer seas.After twenty years of excavation and preparation, the most complete fossil skeleton of an Australopithecine has been unveiled to the public in South Africa. Its discoverer Ron Clarke explains its significance for understanding human evolution.December 16th is the 100th anniversary of Arthur C Clarke. Science writer Marcus Chown and cultural journalist Samira Ahmed join Adam to discuss Clarke's visions and works of science fiction.
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Dec 7, 2017 • 31min

Trophy hunting, Gene drives, Nuclear lightning, Peregrine falcons and drones

Trophy hunters are always after the lion with the largest darkest name and the stag with the most impressive antlers. Research by Rob Knell at Queen Mary University of London finds that removing a small proportion of these top males can drive whole populations to extinction, if their environment is changing.Gene drive is a new genetic technology that could be used to eradicate populations of species of 'pest' animals. The Roslin Institute in Edinburgh has just announced it is to begin research on gene drives to control rat and mouse populations. The Institute's Bruce Whitelaw and Simon Lillico explain how the approach would work and argue that it would be humane compared to traditional methods of vermin control. However there are concerns about its potential ecological consequences - namely the risk of female infertility in the targeted species spreading without no geographical limits. Kevin Esvelt of MIT voices his reservations. Bruce Whitelaw outlines how future research aims to bring gene drives under more control. Researchers in the USA and Japan talk about their discovery of nuclear reactions in lightning strikes, and Caroline Brighton and Graham Taylor of the University of Oxford explain why they have been attaching small cameras and GPS units to peregrine falcons and recording the birds chasing drones.

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