
ICU Ed and Todd-Cast
Two critical care guys walk into a recording studio and breakdown intensive care trials both old and new! We'll also do deep dives on specific topics important to practicing intensive care medicine and have special guests talking about their area of expertise! This podcast is made for educational purposes. The content provided in this podcast, and in any linked materials, is not intended and should not be construed as medical advice and should not be used to diagnose or treat any medical condition. We try to stay away from opinions but all opinions represent our own and not of any entity we work for. Please keep this in mind as you enjoy the podcast!
Latest episodes

Jan 28, 2025 • 1h 6min
CCR Down Under: SCREEN with Adam Wright
Send us a Text Message (please include your email so we can respond!)Episode 57! We were excited to have on this episode Dr. Adam Wright who is a PhD in Bioinformatics to discuss SCREEN or "Electronic Sepsis Screening Among Patients Admitted to Hospital Wards: A Stepped-Wedge Cluster Randomized Trial" published by Arabi et al in JAMA 2024 and presented at the CCR Down Under Conference. A long episode but a lot of good discussionSCREEN (pubmed): https://pubmed.ncbi.nlm.nih.gov/39658862/SCREEN (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2828069If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Jan 14, 2025 • 46min
CCR Down Under: ADAPT-Sepsis
Send us a Text Message (please include your email so we can respond!)Episode 56! In this episode we spend a few minutes talking about making decisions on ECMO initiation but spend most of the episode talking about ADAPT-Sepsis or "Biomarker-Guided Antibiotic Duration for Hospitalized PatientsWith Suspected Sepsis" published by Dark et al in JAMA 2024 and presented at the CCR Down Under Conference.ADAPT-Sepsis (pubmed): https://pubmed.ncbi.nlm.nih.gov/39652885/ADAPT-Sepsis (JAMA): https://jamanetwork.com/journals/jama/article-abstract/2828036If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Dec 31, 2024 • 60min
2024 Year in Review and CCR Down Under
Send us a Text Message (please include your email so we can respond!)Episode 55 and Happy New Year! In this episode we talk broad strokes about the CCR Down Under Conference and the trials that were presented, then Todd and Eddie go over a bunch of articles from the year 2024 that they didn't have time to go over or want to re-emphasize for whatever reason. Big show and we hope you enjoy!TIGHT K: https://pubmed.ncbi.nlm.nih.gov/39215972/PROPHY VAP: https://pubmed.ncbi.nlm.nih.gov/38262428/REVISE: https://pubmed.ncbi.nlm.nih.gov/38875111/Point (withdrawal of ECMO): https://pubmed.ncbi.nlm.nih.gov/39663030/Counterpoint: https://pubmed.ncbi.nlm.nih.gov/39663031/DanGer SHOCK: https://pubmed.ncbi.nlm.nih.gov/38587239/Intubation in physiologic difficult airway guidelines: https://pubmed.ncbi.nlm.nih.gov/39162823/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Dec 17, 2024 • 52min
New/Old: BALANCE and iDIAPASON
Send us a Text Message (please include your email so we can respond!)Episode 54! In this episode we talk about antibiotic duration in bacteremia (BALANCE) and also antibiotic duration in Pseudomonas Ventilator associated pneumonia (iDIAPASON). BALANCE (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2404991BALANCE (pubmed): https://pubmed.ncbi.nlm.nih.gov/39565030/iDIAPASON (ICM): https://link.springer.com/article/10.1007/s00134-022-06690-5iDIAPASON (pubmed): https://pubmed.ncbi.nlm.nih.gov/35552788/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Dec 3, 2024 • 34min
New/New-ish: IVIO and PARAMEDIC-3
Send us a Text Message (please include your email so we can respond!)Episode 53! In this episode we talk about access in patients with out of hospital cardiac arrest. Both articles are similar so we talk in depth about IVIO and then bringing PARAMEDIC-3 to round out our discussion. A good acronym discussion too, don't miss it!IVIO (NEJM): https://www.nejm.org/doi/10.1056/NEJMoa2407616IVIO (pubmed): https://pubmed.ncbi.nlm.nih.gov/39480221/PARAMEDIC-3 (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa2407780PARAMEDIC-3 (pubmed): https://pubmed.ncbi.nlm.nih.gov/39480216/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Nov 19, 2024 • 41min
New/New: INTREPID and PROLABI
Discover the intriguing connection between fever and neurological injuries, and the challenges of managing temperature in stroke patients. Enjoy a light-hearted yet insightful examination of the INTREPID trial on fever prevention. The episode delves into patient comfort in ICUs and how it impacts recovery outcomes. Tune in for a critical look at the PROLABI trial, discussing ventilation strategies for severe brain injuries. Balancing humor with serious medical insights, the hosts dissect essential clinical trial designs and their implications.

Nov 5, 2024 • 23min
LIVE @ CC Bootcamp 2024: NONSEDA
Send us a Text Message (please include your email so we can respond!)We are (were) LIVE at ACNP Critical Care Bootcamp 2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about the NONSEDA trial or "Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients" by Olsen et al published in the New England Journal of Medicine February 2020NONSEDA (pubmed): https://pubmed.ncbi.nlm.nih.gov/32068366/NONSEDA (NEJM): https://www.nejm.org/doi/full/10.1056/NEJMoa1906759If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Oct 22, 2024 • 56min
FAST and IV Fluid Shortage
Send us a Text Message (please include your email so we can respond!)Episode 50! In this episode we talk about SBT frequency and "Frequency of Screening and Spontaneous Breathing Trial Techniques" by Burns et al from JAMA 2024 that was released with the ESICM conference. In our second segment, instead of another trial we talk a little bit about the IV fluid shortage happening in the United States.FAST (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2824928FAST (pubmed): https://pubmed.ncbi.nlm.nih.gov/39382222/If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Oct 7, 2024 • 52min
LIVE @ CHEST2024: Minocycline for delirium and Amio vs lido for cardiac arrest
Send us a Text Message (please include your email so we can respond!)We are LIVE at CHEST2024! Thank you to the organizers of the conference for inviting us do a live show and thank you to everyone who came out to listen! We talk about a few articles that were recently published in CHEST - "Prophylactic Minocycline for Delirium in Critically Ill Patients: A Randomized Controlled Trial" published by Dal-Pizzol et al and then "Comparative Effectiveness of Amiodarone and Lidocaine for the Treatment of In-Hospital Cardiac Arrest" by Wagner et al.We then touch briefly on some articles being presented later at the conference which we might cover soon (stay tuned)!Minocycline for Delirium (pubmed): https://pubmed.ncbi.nlm.nih.gov/38043911/Minocycline for Delirium (CHEST): https://journal.chestnet.org/article/S0012-3692(23)05833-6/abstractAmio vs Lido (pubmed): https://pubmed.ncbi.nlm.nih.gov/36332663/Amio vs lido (CHEST): https://journal.chestnet.org/article/S0012-3692(22)04039-9/abstractIf you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!

Sep 24, 2024 • 35min
New: Long Term Outcomes of ICU Visitation Policies
Send us a Text Message (please include your email so we can respond!)Episode 48! In this episode we talk about the long term effects of ICU visitation policies on families. Long Term Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/39172240/Long Term Outcomes of Visitation (ICM): https://link.springer.com/article/10.1007/s00134-024-07577-3Outcomes of Visitation (pubmed): https://pubmed.ncbi.nlm.nih.gov/31310297/Outcomes of Visitation (JAMA): https://jamanetwork.com/journals/jama/fullarticle/2738289If you enjoy the show be sure to like and subscribe, leave that 5 star review! Be sure to follow us on the social @icucast for the associated figures, comments, and other content not available in the audio format! Email us at icuedandtoddcast@gmail.com with any questions or suggestions! Thank you Mike Gannon for the intro and exit music!