DNA Today: A Genetics Podcast

Picture Genetics Kit Giveaway! Enter to win your own free kit on our Twitter, Instagram, and Facebook. Guests for this episode are from Fulgent Genetics (offering Picture Genetic kits), which is the sponsor of this new Direct To Consumer Genetic Testing Series. Jessica Shiles is a genetic counselor and Dr. Samuel Strom is the lab director. Jessica serves as Fulgent’s Clinical Genetics Marketing Specialist. Her main role is to provide clinical training and expertise to help develop marketing material that is used to educate, support, and inform the patients and providers Fulgent serves. With Jessica’s strong passion for patient advocacy, she also leads Fulgent’s community outreach. She is a fellow Sarah Lawrence College’s alumni where she received her Masters of Science in Human Genetics. Previously Dr. Strom was an assistant professor at the UCLA David Geffen School of Medicine where he pioneered interpreting genomics results in the context of clinical diagnostic testing for rare inherited diseases and cancer. At Fulgent, he is continuing to forward this new science at an industrial scale. He is also an accomplished researcher in the fields of neurogenetics, ophthalmic genetics, and molecular diagnostics, with publications in top journals such as Science, JAMA, Genetics in Medicine, and Human Molecular Genetics. On This Episode We Discuss: Overview of Picture Genetics’ approach to DTCs (including genetic counseling) Difference between DTC genotyping and sequencing Conditions on carrier screening (Picture Parenting) Ideal time for carrier screening Newborn testing for healthy vs sick babies Newborn testing vs newborn screening Conditions on newborn testing (Picture Newborn) Value of newborn testing after negative carrier screening ACMG59 qualification of conditions (Picture Wellness) Purpose of ordering testing on the ACMG59 genes COVID-19 DTC testing, including FDA approval There is one correction during the episode, Jessica mentioned ACMG when she meant to say ACOG. As a DNA Today listener you can order your kits with code “DNATODAY” for a 25% discount and free shipping. Order at picturegenetics.com and the kit will be delivered right to your home! Thanks for Picture Genetics for sponsoring this DTC series. Don’t forget to enter our Picture Genetics Kit Giveaway on our Twitter, Instagram, and Facebook. Stay tuned for the next new episode of DNA Today on September 4th, 2020! New episodes are released on the first Friday of the month with some bonus episodes thrown in there. In the meantime, you can listen to over 125 other episodes on Apple Podcasts, Spotify, or streaming on the website. Questions/inquiries can be sent to info@DNApodcast.com.

Dr. Adam Rutherford is our guest for this second installment of our Direct-To-Consumer Genetic Testing series. He is a geneticist, author, and broadcaster. Dr. Rutherford has a PhD in Genetics, a degree in evolutionary biology, and is an honorary Research Fellow at UCLA. He was an audio-visual content editor for the journal Nature for a decade, and is a frequent contributor to the newspaper The Guardian. On radio, he is the presenter of BBC Radio 4’s flagship science program, Inside Science, as well as many documentaries. On TV, he has presented multiple BBC series including The Beauty of Anatomy, The Gene Code, and award winners Playing God and The Cell. Dr. Rutherford has also been a scientific advisor to films including Biophilia Live, World War Z, The Secret Service and Ex Machina (2015). He has authored multiple books including, “A Brief History of Everyone Who Ever Lived” and the book we will be discussing today, “How to Argue With a Racist: What Our Genes Do (and Don't) Say About Human Difference” which is being released this August! Enter our giveaway for a copy of his book on our Twitter, Instagram, and Facebook. On This Episode We Discuss: How genetics is woven into the history of race Discrepancy of papertrails and ancestry reports from DTCs between European and non-European descent What DTC companies can do to address this racial disparity How genetics of ethnicity contradict Dawkins’ “tyranny of the discontinuous mind” concept How is it possible to not be genetically related to an ancestor What we can learn by comparing the genomes of African and African-American people How consumer ancestry genetic testing affects how we think about our genetic differences Olympics reveal of the limitation genetic predisposition DTCs contribution to racial reification Sponsoring this episode is Advanced Tele-Genetic Counseling (AT-GC) which provides virtual appointments to meet with a certified genetic counselor. These one-on-one conversations can help you understand how your own genetics may play a role in your health. Access to healthcare should not be dependent on where you live, which is why ATGC was founded! You can schedule your telehealth appointment directly on their website. As mentioned in the episode, you can signup here for the next free Phenotips Speaker Series on August 12th at 12pmET. Our host Kira Dineen will be interviewing Ellen Matloff about “The Evolving Role of Genetic Counselors in Precision Medicine”. Stay tuned for the next new episode of DNA Today on August 21st! New episodes are released on the first and third Friday of the month. In the meantime, you can binge 125 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNApodcast.com. And don’t forget to enter the giveaway! If you can’t wait to see if you've won, head over to Amazon to order your copy. Questions/inquiries can be sent to info@DNApodcast.com.

Last chance to nominate DNA Today in the Podcast Awards for the best Science and Medicine. Please take a few minutes to support the show! This episode kicks off our Direct-To-Consumer (DTCs) Genetic Testing Series! Check out our previous episodes about DTCs including episode 116, 105, 91, 80, and 56. Over this brand new series, we are going to be interviewing a whole bunch of experts including authors Adam Rutherford and Libby Copeland about their new books exploring DTCs and we get to hear directly from companies like Fulgent Genetics, JScreen, and 23andMe. So much more to come over the next few months! This series is sponsored by Picture Genetics, who is now offering FDA-authorized COVID-19 test kits. And you don’t have to leave the house, the kits are shipped directly to your home. Ordering takes only a few minutes at picturegenetics.com. Use code “DNATODAY” for 25% and free shipping on all other kits! To start off this series, we are joined by Jeanette McCarthy, MPH, PhD, who is a UC Berkeley trained genetic epidemiologist with current faculty positions at UCSF and Duke. Her interests are in educating stakeholders in the area of precision medicine, including healthcare providers and consumers. In 2014, Dr. McCarthy helped launch the first consumer-facing magazine in this field, Genome, where she served as the founding Editor-in-Chief. Dr. McCarthy is also the founder of Precision Medicine Advisors, where she develops and delivers workshops and online courses related to genetic testing. On This Episode We Discuss: Top companies in the DTC genetic testing industry Differences between patient initiated, physician initiated, and/or medical/clinical grade Lesser known areas of testing including pharmacogenomics Role of FDA regulation Learn more from Dr. Jeanette McCarthy on PrecisionMedicineAdvisors.com. Check out this blog post we mentioned during the episode where Dr. McCarthy explains how the genetic testing industry has developed and some of the recent industry trends and factors impacting its growth. Join host Kira Dineen live on Zoom in the Phenotips Speakers Series on July 27th 12pmET! Kira will be hosting the first installment by interviewing Advanced Tele-Genetic Counseling’s Founder Elizabeth Turner about “Adapting to Virtual Care in Genetic Counseling”. Register for free here. Stay tuned for the next new episode of DNA Today’s DTC series on August 7th with Dr. Adam Rutherford where we discuss his book How To Argue With A Racist: What Our Genes Do (And Don’t) Say About Human Difference. New episodes are released on the first and third Friday of the month. In the meantime, you can binge 125 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNApodcast.com. Questions/inquiries can be sent to info@DNApodcast.com.

Answering your listener submitted questions about the American genetic counseling board exam is the ABGC President, Adam Buchanan, MS, MPH, CGC! Aside from this role at American Board of Genetic Counseling, Adam is an associate professor, genetic counselor and Director of the Geisinger Genomic Medicine Institute. Previously, he was a research associate at Duke Cancer Institute. His clinical expertise includes intimate knowledge of recommended risk management for hereditary cancer syndromes. He is co-leading Geisinger’s MyCode genomic screening program for medically actionable genomic results, and is helping to develop a health services research portfolio on patient-participant, family, and system outcomes of this program. This episode is sponsored by PhenoTips. If you are still drawing pedigrees by hand, you are overdue for an upgrade! PhenoTips provides a free digital pedigree drawing tool. Not only is it intuitive and easy-to-use, it’s 2.5 times faster than your pen and paper. And we all know time is very valuable in the clinic. Give it a try at phenotips.com/signup. On This Episode We Discuss: Timeframe for the boards Structure of the exam Study resources Content on the exam Strategy to approach questions Percentage passing rate (Is there one?) Results and CGC status Accommodating for COVID-19 (Possible Remote Test Taking) Inclusivity boards price and questions Update: As teased by Adam in this episode, ABGC officially announce the boards exam is also being offered with remote proctoring in August 2020. Read more on their website here. Learn more on ABGC’s website, here is the content outline that was referred to throughout this interview. Here is the practice exam for purchase ($55) to access your strengths and weaknesses. Here is a page to learn more about the scoring of the exam and here is a page to see specific passing rates over the last few years. During the interview we also reference #ABGCListens tweetchat, which you can read here on Twitter. For other genetic counseling conversation read and participate in #gcchat on Twitter. You can also follow Adam directly on Twitter. Next episode of DNA Today is launching the brand new Direct-To-Consumer Genetic Testing series on July 17th! This series will be sponsored by Fulgent Genetics. New episodes are released on the first and third Friday of the month with some bonus episodes thrown in there. In the meantime, you can listen to over 125 other episodes on Apple Podcasts, Spotify, or streaming on the website including the previous series about infertility. See what else we are up to on Twitter, Instagram, Facebook and iTunes. Questions/inquiries can be sent to info@DNApodcast.com.

Podcast Award Nominations begin July 1st, 2020! Please help DNA Today receive a fourth nomination (and hopefully a win this year!) by visiting PodcastAwards.com and selecting “DNA Today” in the Science and Medicine category. We can only receive a nomination if YOU nominate the show! This episode concludes DNA Today’s 7 part infertility series. The first episode kicked off with Lauren Isley who shared about fertility genetic counseling. The next two episodes featured a couple who went through reciprocal IVF to have their daughters (part 1 and 2). Filmmakers of fertility movie ANYA joined the show next. Dr. Kara Goldman followed discussing diagnostic fertility testing. Last episode, Genetic Counselor Jennifer Eccles explained the science behind PGT for polygenic conditions. This seventh and final infertility installment explores controversies surrounding fertility with genetic counselor and genetics podcast host, Nick Charles. He is the lead laboratory and quality control counselor at CooperSurgical, a preimplantation genetic testing lab. Prior to working in a laboratory position, he was a prenatal and reproductive genetic counselor at Rutgers-Robert Wood Johnson Medical School, counseling patients with high-risk pregnancies and/or fertility issues in the Maternal Fetal Medicine practice. He earned his bachelor’s degree in pre-med biology from the University of Scranton and his master’s in human genetics and genetic counseling from Sarah Lawrence College. This episode is also one of our crossovers with another genetics podcast. So be sure to hear the other half of our conversation on Nick’s show, Gene Therapy Podcast. Roles are flipped on his show where Nick interviews Kira about how to utilize social media to learn about genetic counseling, and to network and build a career. Sponsoring this episode is Advanced Tele-Genetic Counseling (AT-GC) which provides virtual appointments to meet with a certified genetic counselor. These one-on-one conversations can help you understand how your own genetics may play a role in your health including fertility. Access to healthcare should not be dependent on where you live, which is why ATGC was founded! You can schedule your telehealth appointment directly on their website. On This Episode We Discuss: Preimplantation Genetic Testing (PGT) Appropriate situations and where the line begins to blur Medical guidelines and recommendations Mosaic Embryos: Potential health concerns Regulations around implantation Situations to select and implant Success rate of pregnancies Current and future research Don’t forget to hear the other half of our conversation on Nick’s show, Gene Therapy Podcast. Just search Gene Therapy podcast in our podcast player or listen on his website. Keep up with the show by following on Twitter and Instagram. Stay tuned for the next new episode of DNA Today. New episodes are released on the first and third Friday of the month (with some bonus episodes thrown in there like this one)! In the meantime, you can listen to 125 episodes on Apple Podcasts, Spotify, or streaming on the website. See what else we are up to on Twitter, Instagram, Facebook and iTunes. Questions/inquiries can be sent to info@DNApodcast.com.

This episode continues DNA Today’s series about infertility. Over the last five episodes of DNA Today, we talked with experts in fertility. On the first episode we heard from Lauren Isley, a genetic counselor about artificial reproductive technologies and the genetic counseling side. We also had the Baileys on the show to share their reciprocal IVF journey in part 1 and part 2. The following episode the filmmakers of ANYA, a science fiction film about fertility. Last episode, Dr. Kara Goldman shared her experience in diagnostic fertility testing. Sponsoring the series is LetsGetChecked, check out their home testing kits including fertility, sexual health and others. Receive your own kit for 20% off by using code “DNAToday”. Jennifer Eccles joins the show to discuss PGT-P, preimplantation genetic testing for polygenic conditions. She is the Head of Genetic Counseling at Genomic Prediction Clinical Laboratory. Jennifer has over 20 years of experience in reproductive clinical genetics at institutions like Columbia, Beth Israel Medical Center, and BioReference Laboratories. As a licensed and certified genetic counselor, Jennifer has spent her career discussing genetic testing with individuals and couples at various stages along the path to parenthood. In her current role, Jennifer provides genetic counseling services along with authoring clinical and marketing content. Jennifer's publication history is focused on the patient-facing aspect of genetics and clinical testing. She is also a fellow graduate of Sarah Lawrence’s Human Genetics program. On This Episode We Discuss: Types of PGT PGT-P for Polygenic Conditions Screening vs Diagnostic Testing List of Polygenic Conditions Screened Polygenic Risk Scores PGT-P Steps Cost and Insurance Genetic Counseling Learn more about Genomic Prediction and their PGT-P on their website genomicprediction.com and follow them on Twitter, Instagram, Facebook, and LinkedIn. Stay tuned for the next and final episode of the DNA Today Infertility series! New episodes are released on the first and third Friday of the month. In the meantime, you can binge 123 other episodes on Apple Podcasts, Spotify, streaming on the website, or any other podcast player by searching, “DNA Today”. See what else we are up to on Twitter, Instagram, Facebook, YouTube and our website, DNApodcast.com. Questions/inquiries can be sent to info@DNApodcast.com.

DNA Today stands in solidarity with BLM and in doing so we wanted to share a few resources with you listeners where you can educate yourself by listening to Black voices in our genetics community. You can support BLM through donations to ActBlue here. Dr. Janina Jeff was a guest back on episode 117 where she shared her new podcast, “In Those Genes”, that uses genetics to uncover the lost identities of african descended americans through the lens of black culture. Please, listen and support her show along with other black podcasts like American Origin Stories, She Too STEM, PhDivas among many others. We also wanted to bring awareness to the Minority Genetic Professionals Network. This group supports minority medical genetic providers and trainees to increase the diversity in our profession and to serve minority communities. MGP also provides resources on how to support non-white patients and co-workers. You can also follow them on Twitter and Instagram. Learn more through Twitter accounts like @DecolonizeDNA and @BlackAFinSTEM, articles in AJMG and AACC. This episode continues DNA Today’s series about infertility. Over the last four episodes of DNA Today, we talked with experts in fertility. On the first episode we heard from Lauren Isley, a genetic counselor about artificial reproductive technologies and the genetic counseling side. We also had the Baileys on the show to share their reciprocal IVF journey in part 1 and part 2. The following episode the filmmakers of ANYA, a science fiction film about fertility. Sponsoring the series is LetsGetChecked, check out their home testing kits including fertility, sexual health and others. Receive your own kit for 20% off by using code “DNAToday”. This episode Dr. Kara Goldman shares her experience in diagnostic fertility testing. She is the Medical Director of Fertility Preservation at Northwestern Fertility Reproductive Medicine. Dr. Goldman received her MD from Loyola University Chicago Stritch School of Medicine, completed OB/GYN residency at Northwestern University, and trained in Reproductive Endocrinology and Infertility at New York University where she went on to join the faculty. On This Episode We Discuss: When to pursue fertility testing Which tests are the first ordered Hormones that are measured and importance of timing Common causes of infertility Fertility implications of balanced translocation carriers Fertility preservation You can stay updated with Dr. Goldman on her Twitter account, @karagoldmanmd. Stay tuned for the next new episode of DNA Today on June 19th! New episodes are released on the first and third Friday of every month. In the meantime, you can listen to over 100 other episodes on Apple Podcasts, Spotify, or streaming on the website. See what else we are up to on Twitter, Instagram, Facebook, Youtube, and iTunes. Questions/inquiries can be sent to info@DNApodcast.com.

This episode continues DNA Today’s series about infertility. Over the last few episodes of DNA Today, we talked with experts in fertility. On the first episode we heard from Lauren Isley, a genetic counselor about artificial reproductive technologies and the genetic counseling side. We also had the Baileys on the show to share their reciprocal IVF journey in part 1 and part 2. Sponsoring the series is LetsGetChecked, check out their home testing kits including fertility, sexual health and others. Receive your own kit for 20% off by using code “DNAToday”. It’s been so interesting to hear different perspectives about fertility as it impacts so many people’s lives. Currently 7.3 million Americans are facing infertility! I hope you all have learned a lot alongside us. Be sure to go back and listen to all the fertility episodes if you are interested! On this next installment of the fertility series two guests join the show, documentarian Jacob Okada and anthropologist Carylanna Taylor, PhD who wrote and produced ANYA, a fictional film about fertility. Through their company, First Encounter Productions, Carylanna and Jacob are committed to creating complex characters and compelling stories informed by anthropology, science, and current events. ANYA has had international screenings and was featured as a "Science and Diversity in Film" on Forbes. On This Episode We Discuss: ANYA Film Synopsis Inspiration for ANYA Keeping up with Genetic Technology and News Scientifically Accurate Script Writing Proper Lab Equipment Features Featured Genetic Technology PCR, Sequencing, UCSC Genome Browser, CRISPR Inclusivity in Science Fiction Films Forbes had a fantastic feature of ANYA exploring the diversity in the film. Dr. Ruth McCole, who was a scientist on the set, wrote up her experience here. Rotten Tomatoes gives ANYA a 93%. To explore more about First Encounter Productions you can visit their website. For more information about ANYA and to watch it go to anyamovie.com. Stay tuned for the next new episode of DNA Today. New episodes are released on the first and third Friday of the month. See what else we are up to on Twitter, Instagram, Facebook, Spotify and Apple/iTunes. Questions/inquiries can be sent to info@DNApodcast.com.

This episode is part of DNA Today’s ongoing infertility series. The series was launched hearing from Genetic Counselor Lauren Isley, she shared about artificial reproductive technologies and infertility genetic counseling. Sponsoring the series is LetsGetChecked, check out their home testing kits including fertility, sexual health and others. Receive your own kit for 20% off by using code “DNAToday”. Last episode we heard from Katie and Christina Bailey. They were sharing their journey to parenthood through reciprocal In Vitro Fertilization (IVF). We continue this conversation on this episode, so if you haven’t heard the first part of our discussion, you are going to want to listen to the previous episode where Christina and Katie Bailey talk about the beginning of their story with IVF. The Baileys have a large following of nearly 100,000 on Instagram, so you can check them out @BabyBaileyMamaDrama. On This Episode We Discuss: Conceiving a Second Time Genetic Testing During Pregnancy Talking to Kids About Their Conception Direct-To-Consumer Genetic Testing Finding Biological Relatives Decision to Make Family’s Story Public Cost of IVF Future Kids and Names Advice for People Going Through Fertility Treatments If you are interested in more details about the cost, the Baileys provided a breakdown here. The Bailey’s story was also summed up here. Join nearly 100,000 others in following them on Instagram and Youtube both at @BabyBaileyMamaDrama. You can also check out their blog, babybaileymamadrama.wordpress.com. DNA Today’s infertility series continues on the next episode! New episodes are released on the first Friday of the month with some bonus episode thrown in there. See what else we are up to on Twitter, Instagram, Facebook and iTunes. Questions/inquiries can be sent to info@DNApodcast.com.

This episode continues the DNA Today’s series about infertility. If you haven’t yet heard the episode with Genetic Counselor Lauren Isley, I highly recommend you go back and listen to learn more about the artificial reproductive technologies and the genetic counseling side. It’s a great preview into this episode. Sponsoring the series is LetsGetChecked, check out their home testing kits including fertility, sexual health and others. Receive your own kit for 20% off by using code “DNAToday”. Currently 7.3 million Americans are facing infertility, and this series is bringing awareness to infertility along with teaching the science and genetic side. On this episode, we are going to hear personal perspectives. Joining me are Katie and Christina Bailey. They share their journey to parenthood through reciprocal In Vitro Fertilization (IVF). Christina and Katie have a large following of nearly 100,000 on Instagram, so you can check them out @BabyBaileyMamaDrama. This is part 1 of our conversation, for part 2, you will have to tune into the next episode to hear where the Bailey are today. On This Episode We Discuss: Deciding on Path to Parenthood Educating Friends and Family Choosing a Sperm Donor Hormones for IVF Techniques to Fertilize Eggs Considering Embryo Adoption To hear about the rest of the Bailey’s IVF journey you will have to tune into the next episode of DNA Today! In the meantime, join nearly 100,000 others in following them on Instagram and Youtube both at @BabyBaileyMamaDrama. You can also check out their blog, babybaileymamadrama.wordpress.com. Don’t forget to hear the rest our our conversation in the next episode of DNA Today! New episodes are released on the first Friday of the month with some bonus episode thrown in there. See what else we are up to on Twitter, Instagram, Facebook and iTunes. Questions/inquiries can be sent to info@DNApodcast.com.