Oncotarget

Researcher Michèle Welti discusses the impact of Covid-19 on managing patients with metastatic melanoma. The study analyzed patients receiving therapy and their Covid-19 outcomes. Topics include treatment regimens, severity of Covid-19 courses, and challenges faced during the pandemic.

Researchers discuss the resistance of MMTV New TATTAC mice to anti-PD-1 therapy, linked to macrophage infiltration, fibrosis, and the Wnt pathway in breast cancer. They monitored drug response and identified processes associated with lack of responsiveness to the treatment.

Researchers discuss the development of a novel antibody drug conjugate ASP1235 targeting FLT3 in AML, with potential for safer and more effective treatment. The podcast highlights the importance of reducing off-target toxicity in older AML patients and the efficacy of combining ASP1235 with venetoclax and azacitidine. The triple combination therapy shows promising results in preclinical models, offering hope for refractory AML and potential applications in FLT3 positive cancers.

Researchers Tomofumi Miura and Shuichi Mitsunaga discuss using serum microRNAs as criteria for early palliative care in cancer patients. They explore the potential of miRNAs as biomarkers for predicting referral to palliative care services in advanced cancer patients undergoing anti-tumor treatment.

A discussion on the impact of pyrethroid derivatives on human cells, including their role in inducing cellular changes like lipid peroxidation and altered transcription factors. The study highlights potential risks of these derivatives in promoting hematological cancers and immune-related disorders.

Researchers discuss the potential of plasma growth hormone as a predictive biomarker for response to atezolizumab and bevacizumab in advanced hepatocellular carcinoma patients, showing promising results in predicting treatment outcomes.

Explore the fascinating world of exosomes and their potential in precision medicine. Learn about bioorthogonal chemistry and its innovative approach to targeting exosomes for drug delivery. Discover the challenges and opportunities in leveraging exosomes for cell-to-cell communication. Dive into the transformative impact of bioorthogonal reactions on clinical biomedical practices.

Drs. Kerri Winters-Stone and Jacob Raber discuss their study on how APOE genotype affects cancer survivors' response to exercise interventions. They explore the impact of different exercise modalities in reducing falls post-chemotherapy and how genetic factors influence strength training outcomes for survivors. The podcast highlights the unique health challenges faced by cancer survivors in the US.

Exploring the use of Plasma Growth Hormone as a potential biomarker for response to standard therapies in advanced liver cancer. Researchers identified a significant gap in research on biomarkers and conducted a study to explore this further. The study aims to shed light on current screening challenges and standard therapies for advanced hepatocellular carcinoma patients.

The podcast discusses the correlation between p-STAT3, c-Myc, and P2-HNF4α expression in nonalcoholic fatty liver disease. It explores the potential of these factors as biomarkers for assessing hepatocellular carcinoma risk in NAFLD patients. The chapter also delves into the relationships between gene expressions in NAFLD, highlighting the associations of p-STAT3 with hypertension and c-Myc with obesity, diabetes, and advanced fibrosis.