Researchers discuss the role of metabolic enzyme GLS2 in regulating cell death (ferroptosis) in liver cancer cells, highlighting the potential for targeted therapies and immunotherapies. GLS2's clinical relevance and therapeutic potential for hepatocellular carcinoma are explored.

Researchers from Columbia University discuss the role of GLS2 in inducing ferroptosis and its potential therapeutic implications for liver diseases. They explore its relationship with p53 and SLC7A11 and highlight a recent study validating GLS2's promotion of ferroptosis in mouse models.

Researchers discuss the role of nuclear morphology in breast cancer metastasis and the importance of immunofluorescence staining. They explore the physical barriers faced by cancer cells during metastasis and highlight the correlation between aemarin expression and survival time in breast cancer patients.

This podcast discusses the challenges of temozolomide treatment for glioblastoma and the role of the GBP3-STING interaction in the development and recurrence of this tumor. It explores the impact of GBP3 upregulation on temozolomide response, which is associated with worse survival outcomes.

Dr. Omkar Desai discusses the significance of HER3 in promoting cancer cell growth and chemo resistance. Challenges in translating preclinical studies on HER3 targeted therapies to clinical trials and HER3 overactivation as a resistance mechanism in cancer cells are explored. Emphasizing the importance of identifying HER3 expression and gene fusions as predictive biomarkers and developing combination therapies to combat resistance.

Researchers explore the role of cancer stemness in drug resistance of colorectal cancer cells. They found that a triple combination treatment against BRAF, EGFR, and MEK significantly reduced stemness and oncogenic signaling pathways in these cells.

Researchers discuss the potential of targeting STAT3 as a therapeutic approach for pediatric H3K27M-mutant DMGs, a challenging type of brain tumor with limited treatment options.

This podcast explores the genetic factors that contribute to early breast cancer in the Kazakh population, highlighting the importance of personalized risk assessment. The study identifies specific variants in cancer predisposing genes, providing valuable insights for genetic testing.

In this podcast, researcher Meghan J. Price discusses UDP-glucose dehydrogenase (UGDH) and its role in tumor progression. The review paper explores UGDH as a molecular indicator of tumor progression, its involvement in cancer signaling pathways, and potential therapeutic targets and prognostication markers.

Researchers Monal Patel and Marcus E. Peter from Northwestern University discuss an ancient anti-cancer mechanism called DISE that senses mutational load in cancerous cells. They explore its potential in cancer treatment by targeting essential survival genes.