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Big Biology

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10 snips
Mar 6, 2025 • 25min

Secrets in the structure (Ep 131)

Scott Edwards, the Alexander Agassiz Professor of Zoology and Curator of Ornithology at Harvard, dives into the evolution of genomic research. He explores how new DNA sequencing technologies help reveal complex genomic structures, likening them to navigating a well-organized bookstore. The conversation shifts to cooperative breeding among babblers in varied habitats, highlighting the role of genomic advancements in understanding ecological traits. Edwards emphasizes the intricate connections between natural history and genomics, shaping our understanding of biodiversity.
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Feb 26, 2025 • 6min

Post-match chat: A direct hit

In this post-match chat, Marty and Cam discuss our most recent episode “A direct hit”, with guest Holden Thorp. This is a quickly evolving situation, and on Friday last week, a federal judge continued to block the cut to the NIH indirect cost rate. And just a few days ago, Holden wrote another editorial Come together, right now. He writes about the continued onslaught of cuts, firings, and changes to the science system in the United States, and how members of the scientific community can respond. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit bigbiology.substack.com/subscribe
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Feb 21, 2025 • 59min

A Direct Hit (Ep 130)

Will a change in policy at the National Institutes of Health derail science in the US? How does the “indirect cost rate” for federal research grants fuel research?In this episode, we talk with Holden Thorp, a chemist and editor-in-chief of Science, about his recent editorial A Direct Hit. In it, he writes about the NIH announcing a significant cut to their indirect cost rate and the consequences to science in the US if this change takes effect. “Indirect” or “overhead” costs are the portions of grants that are allocated to support research grant but aren’t for the research itself. Things like grant administration, compliance, and research infrastructure are covered by these funds (check out the comic below by Matteo Farinella for details). These costs have traditionally been shared by universities and the federal government, but with the proposed cut to the indirect cost rate, universities may need to make up for the deficit or change their operations. We discuss with Holden how this change could have widespread impacts on scientific research as well as the economy including our competitiveness on the global stage.Comic by Matteo Farinella (Instagram, Substack) This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit bigbiology.substack.com/subscribe
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Feb 20, 2025 • 2min

Behind the scenes audio

Here’s a little sneak peek into what goes on behind the scenes when we choose a title for an episode. In this snippet, Cam and Marty discuss the title of our most recent episode: “Beaks on (fitness) peaks.” This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit bigbiology.substack.com/subscribe
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Feb 13, 2025 • 29min

Beaks on (fitness) peaks (Ep 129)

This is a free preview of a paid episode. To hear more, visit bigbiology.substack.comWhich factors lead to the evolution of reproductive isolation? What role does hybridization play in speciation? Why are there so many bird species in the tropics?In this episode, we host Trevor Price, a Professor in the Department of Ecology and Evolution at the University of Chicago and a Fellow of the Royal Society to talk about the evolutionary proce…
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Jan 23, 2025 • 23min

Homo pathogenesis (Ep 128)

Sabrina Sholts, Curator of Biological Anthropology at the Smithsonian, discusses the fascinating link between human behavior and infectious disease transmission. She reveals how seasonal changes influence the spread of diseases, debunking myths around cold weather illnesses. Sholts shares insights from the 'Outbreak' exhibit, emphasizing the vital connections between human, animal, and environmental health. The conversation also touches on adaptations during the COVID-19 pandemic, highlighting the need for public education and community engagement in combating future outbreaks.
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Jan 2, 2025 • 31min

Devo-lutionary theory (Ep 127)

This is a free preview of a paid episode. To hear more, visit bigbiology.substack.comWhat role does development play in evolution? How can biology incorporate a broader, more complex definition of what it means to be an organism?In this episode, we talk with Scott Gilbert and Tobias Uller, two of the authors who wrote Evolution Evolving: The Developmental Origins of Adaptation and Biodiversity. Tobias is a professor of Biodiversity and …
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Dec 5, 2024 • 40min

What does it take to change the world? (Ep 126)

This is a free preview of a paid episode. To hear more, visit bigbiology.substack.comHow have organisms changed the Earth and what can humans learn from its deep past?On this episode, we talk with Stephen Porder, a Professor of Ecology, Evolution, and Organismal Biology and the Associate Provost for Sustainability at Brown University. Stephen is also the author of Elemental: How Five Elements Changed Earth’s Past and Will Shape Our Futu…
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Nov 14, 2024 • 1h 27min

A quiet place (Ep 125)

How do natural selection and sexual selection interact? What can observing adaptive radiation in the wild teach us about evolution?On this episode, we talk with Dale Broder, an Assistant Professor at American University, and Robin Tinghitella, an Associate Professor at the University of Denver. They study the Pacific field cricket, a fascinating organism that exemplifies both adaptive radiation and the interaction of natural selection and sexual selection. This species uses song for mate attraction, but the song also attracts Ormia ochracea, a fly that parasitizes the cricket. The fly recently invaded areas where the cricket is common and in response, some crickets evolved differentsongs and even silence. We talk with Robin and Dale about how their research team characterizes these cricket songs and the different wing morphologies that produce the songs. We also discuss the role of female preference (or lack thereof) in the evolution of different mating songs and how remarkably rapidly this song evolution occurred.This episode was supported by a grant to Dale and Robin from the National Science Foundation.Cover art: Keating Shahmehri. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit bigbiology.substack.com/subscribe
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Oct 24, 2024 • 34min

Spiny, but social (Ep 124)

This is a free preview of a paid episode. To hear more, visit bigbiology.substack.comWhat are spiny mice and why are they so social? What about their brains makes them gregarious? Might network neuroscience be a useful framework for understanding spiny mice behavior?On this episode, we talk with Aubrey Kelly, an Assistant Professor in Psychology at Emory University. Aubrey is a behavioral neuroscientist working on many vertebrate specie…

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