In this episode Professor Sebastiano introduces ERA, Epigenetic Reprogramming of Age technology and talks about his thoughts on some of the causes of aging Professor Vittorio Sebastiano manages a lab in Stanford University which developed and patented technology for partial cellular reprogramming. He co-founded Turn Bio, where he is now Head of research, to translate this technology into clinical applications. And with that, let me start the interview. Turn Bio website https://www.turn.bio/ Professor Sebastiano's lab at Stanford https://med.stanford.edu/stemcell/institutefaculty/sebastiano.html Transient non-integrative expression of nuclear reprogramming factors promotes multifaceted amelioration of aging in human cells https://pubmed.ncbi.nlm.nih.gov/32210226/ NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ 15% Discount on Renue By Science with Code MHS15 until May 01 2023 ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Newman talks about ketones as a fuel for the brain and how this becomes more important as we age and the brain can become less able to use glucose. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies. Dr Newman's lab at the Buck Institute https://www.buckinstitute.org/lab/newman-lab/ And at University of California, San Francisco. https://medicine.ucsf.edu/people/john-newman NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Newman talks the ITP lifespan trials that used butanediol but did not see a significant result. He covers what might have caused this and some of the chemistry behind butanediol and butyrate. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies.   Dr Newman's lab at the Buck Institute https://www.buckinstitute.org/lab/newman-lab/ And at University of California, San Francisco. https://medicine.ucsf.edu/people/john-newman   NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Newman talks ways of boosting ketones through ketone supplements, what the different types are and what has been seen with them in human trials. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies. Dr Newman's lab at the Buck Institute https://www.buckinstitute.org/lab/newman-lab/ And at University of California, San Francisco. https://medicine.ucsf.edu/people/john-newman NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Newman talks about experiments that he and other teams have run on mice lifespan and healthspan while they were on ketogenic diets. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies. Dr Newman's lab at the Buck Institute https://www.buckinstitute.org/lab/newman-lab/ And at University of California, San Francisco. https://medicine.ucsf.edu/people/john-newman   NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Newman discusses ketones and their impact on aging. Dr John Newman is a professor at the Buck Institute and at University of California, San Francisco. He hopes to translate what we are learning of the pathways that control aging into therapies to improve the health and independence of older adults. His research at the Buck studies the molecular details of how diet regulate the pathways that control aging, with a focus on ketone bodies. Dr Newman's lab at the Buck Institute https://www.buckinstitute.org/lab/newman-lab/ And at University of California, San Francisco. https://medicine.ucsf.edu/people/john-newman NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Davidsohn discusses the next generation therapies that Rejuvenate Bio are working on. We also discuss, klotho, RJB02 and his personal protocol. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper mentioned in the interview A single combination gene therapy treats multiple age-related diseases https://pubmed.ncbi.nlm.nih.gov/31685628/ NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Davidsohn discusses taking RJB01 to trial with humans for a rare heart disease and how gene therapy is viewed by the FDA. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper mentioned in the interview A single combination gene therapy treats multiple age-related diseases https://pubmed.ncbi.nlm.nih.gov/31685628/ NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Davidsohn discusses how the gene therapy helps with heart health and is only required one time. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper mentioned in the interview A single combination gene therapy treats multiple age-related diseases https://pubmed.ncbi.nlm.nih.gov/31685628/ NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/

In this episode Dr Davidsohn talks about the first therapy Rejuvenate Bio is working on which restores a more youthful protein expression in the liver which then impacts the rest of the body. Dr Noah Davidsohn is a founder and Chief Scientific Officer of Rejuvenate Bio a company developing gene therapies to treat aging and age related diseases. Rejuvenate Bio website https://www.rejuvenatebio.com/ Dr Davidsohn's paper mentioned in the interview A single combination gene therapy treats multiple age-related diseases https://pubmed.ncbi.nlm.nih.gov/31685628/ NOVOS Core & NOVOS Boost https://novoslabs.com/?ref=3957 $5 off any purchase if users use code MODERN5 10% off DoNotAge all products with discount code MODERNHEALTHSPAN https://donotage.org/products/ 10% Discount on Renue By Science products with code MHS https://renuebyscience.com/ ProHealth 10% of all products Code MODERN : https://www.prohealth.com/