The Pulse

What if treatments or even cures for devastating rare diseases already existed — and were just waiting to be discovered? On this podcast extra, we dive into the extraordinary journey of physician and researcher David Fajgenbaum, cofounder of Every Cure. After facing death five times due to a rare illness called Castleman Disease, Fajgenbaum not only discovered his own treatment, but also launched an ambitious project using AI to unlock existing drugs for countless other conditions. He has a new TED Talk and was recently featured in Time Magazine’s list of “The World’s Most Influential Rising Stars.” Fajgenbaum’s life is also the subject of an upcoming movie based on his memoir “Chasing My Cure.” Listen to his incredible story of resilience, the profound lessons he’s learned from living in "overtime," and how his work is already saving lives by repurposing treatments hiding in plain sight.

We often think of digital distractions, from TikTok to newsfeeds, as a way of giving our brains a break. But in reality, they could be doing the opposite. We talk with psychologist Marc Berman about a better way of restoring our focus — spending time in nature. We also try a dopamine fast, to see if it can really improve our attention spans.

Many adventurers and researchers feel the call of the wild — a force tugging them to explore, climb distant mountains, venture into faraway forests, and discover or rediscover something: a creature, a place, some new clue. On this episode: Adventures in the Wild, featuring the mythical golden toad, raging elephants, and poisonous snakes.

In its heyday, “The Biggest Loser” was one of the biggest shows on TV. But now, nine years after it went off the air, a  Netflix docuseries and new book by leading obesity researcher Kevin Hall, are prompting a re-examination of the show’s tactics, and some of the surprising discoveries it led to surrounding metabolism and weight loss.

Different Patients, Different Outcomes

Most of us take our muscles for granted, but they play a bigger role in our physical and mental health than most people realize. On this encore episode, we explore their cultural and scientific significance. We hear about the history of weight-lifting, along with how it went from niche hobby to medical treatment, and learn about the intricate biology and beauty of our muscles.

When we see surprising couples, like Liam Neeson and Pamela Anderson, we can’t help but wonder what brought them together. In this podcast extra, we explore the mysteries of attraction and love. We talk with researcher Paul Eastwick about the idiosyncratic factors that go into attraction, and behavioral scientist Logan Ury coaches us on the science of optimizing online dating.

We think of Martians as belonging to the realm of sci-fi — but in the early 1900s, a radical idea swept the nation, scientists included: that Martians weren’t only real, they were intelligent beings with their own sophisticated civilization. On this episode, we hear about the astronomer who pushed “Mars Mania,” and a cautionary tale of what happens when belief trumps science.

It seems like we’re all constantly striving to be more productive — to find the right hacks or systems or habits that will allow us to squeeze more from our days. But is maximum  productivity really desirable, or are we missing the bigger picture while running on that treadmill? On this episode, we look at productivity — what works, what doesn’t, and how we can redefine it in a changing world.

David Zweig, an investigative journalist and author of 'An Abundance of Caution,' dives into the shaky decisions behind school closures during the pandemic and their profound impact on students. Holly Korbey, an education reporter and founder of The Bell Ringer, discusses the transformative role of AI tools like ChatGPT in classrooms. They address the challenges of adapting to new technologies, the intense pressures of 'Ivy League fever,' and the evolving landscape of education shaped by the pandemic and modern innovations.