The Effective Statistician - in association with PSI

Alexander Schacht and Benjamin Piske, biometricians, statisticians and leaders in the pharma industry
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Feb 3, 2020 • 44min

Impact of AI on Clinical Development

Interview with Karim Malki Click this link to go to the homepage of this episode! Karim shares about his career, his roles, and different approaches and methods. We also discuss the following points: Machine learningAIPredictive analyticsData scienceDifferent statistical methods and limitationsDifferent tools and applications Statistical innovation Listen to this episode, learn from it, and share it with others!
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Jan 27, 2020 • 1h 2min

The data ops manifesto

Interview with Christopher Bergh Click this link to go to the homepage of this episode! The data ops manifesto can be found here and lists these 18 points - some of which are discussed in more detail in this episode. Data Ops Principles: Continually satisfy your customerValue working analyticsEmbrace changeIt's a team sportDaily interactionsSelf-organizeReduce heroismReflectAnalytics is codeOrchestrateMake it reproducibleDisposable environmentsSimplicityAnalytics is manufacturingQuality is paramountMonitor quality and performanceReuseImprove cycle times
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Jan 20, 2020 • 34min

6 Effective leadership behaviours for statisticians

Click this link to go to the homepage of the post. The 6 behaviours we’re speaking about are: Being confidently relaxedBeing decisiveBeing knowledgeableBeing friendlyBeing curiousBeing vulnerable Here’s the link to the TED talk by Brene Brown, which was watched already over 44 million times (status November 2019): https://www.ted.com/talks/brene_brown_on_vulnerability?language=en#t-68179 Listen to this episode and share it with others who might learn from it!
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Jan 14, 2020 • 1h 4min

Helping statisticians having a bigger role

Interview with Andy Grieve Click this link to go to the homepage of this episode! Today's interview is surely beneficial to everybody. Andy Grieve has a lot of experiences across the industry as academia and other senior roles. We also talk about the following points: When did you realize for yourself, that statisticians should and can play a bigger role?How would the health sector look like, if statisticians would have considerably more influence - e.g. if all the pharma companies would have something like a chief statistical officer?What are the factors, that play in favor of statisticians gaining more influence?What do you see as the biggest barriers for statisticians gaining more influence?What would you recommend to other statisticians to achieve a bigger influence?Do you have different recommendations for statisticians earlier or later in the career? Listen to this interview and listen to others who can learn from it!
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Jan 6, 2020 • 40min

Overview of different indirect comparison approaches and methods

Click this link to go to the homepage of the post. We specifically address the following points: Reasons for IC The classical Bucher approach vs matching adjusted indirect comparisons (MAIC)How to incorporated meta-analysesDifferent network-meta-analyses approaches (NMA): Bayes vs Frequentistsystematic literature reviews (SLR)Cochrane handbookTools VisualizationsBias Precision vs biasPre-specified vs post-hocSecondary vs primary endpointsPower of ICPublish detailed analysesFurther references:PRISMA http://prisma-statement.org/PRISMAStatement/Earlier podcast episode:Network meta-analyses: why, what, and how Listen to this episode and know more about Indirect Comparison now!
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Dec 23, 2019 • 47min

Christmas episode 2019

Click this link to go to the homepage of this post! During this episode, we will review some of the highlights from this year. It’ll help you to remember a couple of lessons learned or inspire you to listen to some episodes (again). We will talk about the following: LeadershipThe look beyond pharmaData scienceBenefit-RiskCareerNonparametricVisualizationProductivityAnd an outlook into 2020 Otherwise, enjoy your Christmas break and we’re taking a week off on New year's eve and start again on the seventh of January. Listen to this episode and become an effective statistician! Merry Christmas!
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Dec 19, 2019 • 41min

CALC Episode 5: You’re hired! How to Fail to be Rejected During the Interview Process

Application process and interview tips with Rhian Jacob and Rachael Loftus Click here to get to the homepage of episode 5
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Dec 16, 2019 • 23min

Baseline testing

A widespread but difficult to treat disease Click this link to go to the homepage of the post. I once reviewed tables for a randomized study and noticed several comments about testing the baseline characteristics. The commenters were arguing which test would be best to test for the differences between the 2 randomized groups at baseline. This made my first angry about the wasted time and then curious about the reasons, statisticians still do this. In today's episode, Benjamin and I discuss some backgrounds for baseline testing in randomized studies. Listen to this episode, share it with others who might learn from it, and be an effective statistician!
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Dec 9, 2019 • 52min

Seeing through the mist - consequences of decisions in phase II

Interview with Trevor Smart Click this link to go to the homepage of this episode! In this episode, Trevor and I discuss a case study to go through the step by step procedure of phase II. We also talk about the following points: What are decision rules?How can we use prior elicitation?What and how do you come to a prior distribution and what is a design prior?What role do relevant and non-relevant differences play here?Any recommended reading?What does the listener need to do differently to make sure, better decisions are made in phase II? Listen to this podcast now!
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Dec 5, 2019 • 31min

CALC Episode 4: Be Significant: What Employers Look for

Want to know how to be the perfect candidate? Click here to get to the homepage of episode 4

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