New Books in Technology

Advances in medicine have made possible better treatments for widespread, familiar human illnesses like cancer, diabetes, and heart disease. Yet there are thousands of much less common diseases, most of genetic origin, each classed as rare because it afflicts only a small number of people. These patient groups were long ignored by a pharmaceutical industry that judged them too small to provide a return on the investment needed to develop an effective remedy. Yet these orphaned diseases collectively caused misery and expense, often far greater than did more common ailments, for tens of millions of individuals and their families.Forty years ago, a revolution that transformed the prospects of patients with rare diseases was lit by three sparks. The passage of the 1983 U.S. Orphan Drug Act resulted from public pressure brought by rare disease patients, their families, and advocates. The AIDS epidemic triggered additional activism, compounded when patients with the rare disease hemophilia became HIV-positive after infusion of tainted blood products. And the third spark was the emergence in the early 1980s of biotechnology companies like Genentech, Amgen, and Biogen employing then-new genetic engineering instead of conventional approaches to pharmaceutical development. Soon after, Genzyme became the first company to develop a treatment for a rare genetic disorder, Gaucher disease, which would come to transform the industry.Jim Geraghty has been a passionate participant in the orphan drug revolution since its inception--a leader in the field as a strategy consultant, biotechnology executive, and venture entrepreneur. Inside the Orphan Drug Revolution: The Promise of Patient-Centered Biotechnology (Cold Springs Harbor Lab Press, 2022) is in part a history, with eyewitness accounts of advances as they occurred and portraits of the pioneering scientists and physicians, tireless activists, and visionary business leaders who made the revolution happen. And it tells deeply personal stories of patients and parents willing to risk new, untried therapies. But Geraghty also uses his exceptional experience and vantage point to look forward to the immense promise of the newest technologies like gene therapy and gene editing for the treatment of patients today and tomorrow. He concludes with thoughtful consideration of important questions. Why do drugs to treat orphan diseases cost so much? How can we ensure they are affordable? How can their effectiveness be responsibly assessed? And how can access to them be expanded internationally? This book graphically and poignantly illustrates how far an important healthcare revolution has come and reminds us that if not nurtured, it could end before its immense promise has been fulfilled. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

In Wandering Games (MIT Press, 2022), Melissa Kagen analyzes wandering within different game worlds, viewed through the lenses of work, colonialism, gender, and death. Wandering in games can be a theme, a formal mode, an aesthetic metaphor, or a player action. It can mean walking, escaping, traversing, meandering, or returning. Kagen introduces the concept of “wandering games,” exploring the uses of wandering in a variety of game worlds. She shows how the much-derided Walking Simulator—a term that began as an insult, a denigration of games that are less violent, less task-oriented, or less difficult to complete—semi-accidentally tapped into something brilliant: the vast heritage and intellectual history of the concept of walking in fiction, philosophy, pilgrimage, performance, and protest. Kagen examines wandering in a series of games that vary widely in terms of genre, mechanics, themes, player base, studio size, and funding, giving close readings to Return of the Obra Dinn, Eastshade, Ritual of the Moon, 80 Days, Heaven’s Vault, Death Stranding, and The Last of Us Part II. Exploring the connotations of wandering within these different game worlds, she considers how ideologies of work, gender, colonialism, and death inflect the ways we wander through digital spaces. Overlapping and intersecting, each provides a multifaceted lens through which to understand what wandering does, lacks, implies, and offers. Kagen’s account will attune game designers, players, and scholars to the myriad possibilities of the wandering ludic body.Rebekah Buchanan is a Professor of English and Director of English Education at Western Illinois University. Her research focuses on feminism, activism, and literacy practices in youth culture, specifically through zines and music. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

How should humans respond to our ongoing human-made climate catastrophe? To answer that question, Recall this Book turned to prize-winning climate reporter Elizabeth Kolbert, who visited Brandeis this Fall. The topic was Under a White Sky, her recent book that documents the responses to the climate crisis ranging from a form of climate engineering that shoots reflective particles into the air to cool the atmosphere, to negative emission technologies that capture and inject carbon dioxide underground."You'd have to be pretty hard-hearted not to feel called to some kind of action when you see what we humans have done." But Elizabeth wonders what the best alternatives are. Should we set aside half the earth for biodiversity? Why is it that genetic engineering has become the cultural flashpoint for fear of unintended consequences? There are no easy answers at this point. Elizabeth thinks that if you're not frightened by what's going right now, including American politics around vaccination refusal, you're not paying attention.Because this episode is associated with the annual Brandeis New Student Book Forum, first-year students Hedy Yang and Srinidhi Sriraman (who also goes by Nidhi) jump in with some thoughts.Noticing repeated mentions of Henry David Thoreau in the book, Nidhi inquires about his role in inspiring Elizabeth's writing. Hedy's question about environmental justice and the comparative agency of rich and poor countries moves Elizabeth to talk about the staggering inequities in consumption and the goal of convergence in carbon emissions. What is the mechanism by which this happens, though? Do humans have the right to implement these technologies? Is the solution to issues created by human control really more control?Mentioned in the Episode E.O. Wilson, Half Earth "Gene editing could revive a nearly lost tree"; the chestnut gene splicing debate in a recent Washington Post article. (Elizabeth has reported on Bill Powell's work) Mary Shelley, Frankenstein (1818) Cormac McCarthy, The Road (2006) Cli-fi: climate fiction in all its bleakness. For example, Margaret Atwood's Oryx and Crake. Kim Stanley Robinson, Ministry for the Future Rob Nixon, Slow Violence: how to see things happening at different time scales. Rachel Carson, Silent Spring (1962) Henry David Thoreau, "the touchstone" of American nature writing. e.g Walden (1854); dated yes, but "in most ways ahead of his time" Des Poissons dans le Desert: Elizabeth's book title in French! Listen to the episode here.Read the transcript here.Special credit and thanks for this episode goes to Hedy Yang and Srinidhi Sriraman, who took part in the audio editing and the preparation of the show notes, respectively. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

The Nuclear Club: How America and the World Policed the Atom from Hiroshima to Vietnam (Stanford UP, 2022) reveals how a coalition of powerful and developing states embraced global governance in hopes of a bright and peaceful tomorrow. While fears of nuclear war were ever-present, it was the perceived threat to their preeminence that drove Washington, Moscow, and London to throw their weight behind the 1963 Limited Test Ban Treaty (LTBT) banishing nuclear testing underground, the 1967 Treaty of Tlatelolco banning atomic armaments from Latin America, and the 1968 Nuclear Non-Proliferation Treaty (NPT) forbidding more countries from joining the most exclusive club on Earth.International society, the Cold War, and the imperial U.S. presidency were reformed from 1945 to 1970, when a global nuclear order was inaugurated, averting conflict in the industrial North and yielding what George Orwell styled a "peace that is no peace" everywhere else. Today the nuclear order legitimizes foreign intervention worldwide, empowering the nuclear club and, above all, the United States, to push sanctions and even preventive war against atomic outlaws, all in humanity's name.Grant Golub is an Ernest May Fellow in History and Policy at the Harvard Kennedy School and a PhD candidate in the Department of International History at the London School of Economics and Political Science. His research focuses on the politics of American grand strategy during World War II. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

Digital platforms controlled by Alibaba, Alphabet, Amazon, Facebook, Netflix, Tencent and Uber have transformed not only the ways we do business, but also the very nature of people's everyday lives. It is of vital importance that we understand the economic principles governing how these platforms operate. Paul Belleflamme and Martin Peitz's book The Economics of Platforms: Concepts and Strategy (Cambridge UP, 2021) explains the driving forces behind any platform business with a focus on network effects. The authors use short case studies and real-world applications to explain key concepts such as how platforms manage network effects and which price and non-price strategies they choose. This self-contained text is the first to offer a systematic and formalized account of what platforms are and how they operate, concisely incorporating path-breaking insights in economics over the last twenty years.Martin Peitz is professor of economics at the University of Mannheim (since 2007), a director of the Mannheim Centre for Competition and Innovation – MaCCI (since 2009). He has been member of the economic advisory group on competition policy (EAGCP) at the European Commission (2013–2016), an academic director of the Centre on Regulation in Europe, CERRE (2012–2016) and head of the Department of Economics (2010–2013). Martin has widely published in leading economics journals. He also frequently trains and advises government agencies in Europe and abroad on competition and regulation issues.Peter Lorentzen is economics professor at the University of San Francisco. He heads USF's Applied Economics Master's program, which focuses on the digital economy. His research is mainly on China's political economy. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

Digital Activism in Russia: The Communication Tactics of Political Outsiders (Palgrave MacMillan, 2022) examines various forms of Russian online anti-establishment resistance, focusing in particular on the period between 2016 and 2019. Grounded in qualitative content analysis of the YouTube videos and social media activities of opposition activist Alexey Navalny and his associates, the book covers the history of digital resistance associated with this cohort, its style and strategies, and the impact that this form of political communication has had on the Russian public sphere.Sofya Glazunova is a Postdoctoral Research Fellow within the Digital Media Research Centre at the Queensland University of Technology in Australia. Glazunova specialises in political communication, digital resistance, Russian media, disinformation, fake news, and digital propaganda. In addition to Digital Activism in Russia: The Communication Tactics of Political Outsiders (2022), she is the co-author of the Global Disinformation Index report entitled Disinformation Risk Assessment: The Online News Market in Australia (2021).Iva Glisic is a historian and art historian specialising in modern Russia and the Balkans. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

Over the past twenty years, DNA ancestry testing has morphed from a niche market into a booming international industry that encourages members of the public to answer difficult questions about their identity by looking to the genome. At a time of intensified interest in issues of race and racism, the burgeoning influence of corporations like AncestryDNA and 23andMe has sparked debates about the commodification of identity, the antiracist potential of genetic science, and the promises and pitfalls of using DNA as a source of "objective" knowledge about the past. Permanent Markers: Race, Ancestry, and the Body After the Genome (University of North Carolina Press, 2021) engages these debates by looking at the ways genomic ancestry testing has been used in Brazil and the United States to address the histories and legacies of slavery, from personal genealogical projects to collective racial politics. Reckoning with the struggles of science versus capitalism, "race-blind" versus "race-positive" public policies, and identity fluidity versus embodied experiences of racism, Permanent Markers seeks to explain why those of us in societies that have broadly embraced the social construction of race continue to search for, and find, evidence that our bodies are marked permanently by the past.Sarah Abel is British Academy Postdoctoral Fellow at the University of Cambridge's Centre of Latin American Studies. Reighan Gillam is Associate Professor in the Department of Anthropology at University of Southern California. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

In The Handbook of Banking Technology (John Wiley & Sons, 2021), Walker and Morris provide a first comprehensive view of the systems that support a bank. During the interview, they bring out the interactions of these components and how the themes they touch on in the book come together. Years of first-hand experience combined with detailed research come together to explain the intricacies of the technological architecture of modern banking. Quite often the authors provide a long-term perspective of how these applications develop in order to provide a better understanding of how we got to where we are. The other podcast mentioned in this interview is James Bessen "The New Goliaths". Bernardo Batiz-Lazo is currently straddling between Newcastle and Mexico City. You can find him on twitter on issues related to business history of banking, fintech, payments and other musings. Not always in that order. @BatizLazo Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

Corporate concentration has breached the stratosphere, as have corporate profits. An ever-expanding constellation of industries are now monopolies (where sellers have excessive power over buyers) or monopsonies (where buyers hold the whip hand over sellers)—or both.In Chokepoint Capitalism: How Big Tech and Big Content Captured Creative Labor Markets and How We'll Win Them Back (Beacon, 2022), scholar Dr. Rebecca Giblin and writer and activist Cory Doctorow argue we’re in a new era of “chokepoint capitalism,” with exploitative businesses creating insurmountable barriers to competition that enable them to capture value that should rightfully go to others. All workers are weakened by this, but the problem is especially well-illustrated by the plight of creative workers. From Amazon’s use of digital rights management and bundling to radically change the economics of book publishing, to Google and Facebook’s siphoning away of ad revenues from news media, and the Big Three record labels’ use of inordinately long contracts to up their own margins at the cost of artists, chokepoints are everywhere.By analyzing book publishing and news, live music and music streaming, screenwriting, radio and more, Giblin and Doctorow deftly show how powerful corporations construct “anti-competitive flywheels” designed to lock in users and suppliers, make their markets hostile to new entrants, and then force workers and suppliers to accept unfairly low prices.In the book’s second half, Giblin and Doctorow then explain how to batter through those chokepoints, with tools ranging from transparency rights to collective action and ownership, radical interoperability, contract terminations, job guarantees, and minimum wages for creative work.Chokepoint Capitalism is a call to workers of all sectors to unite to help smash these chokepoints and take back the power and profit that’s being heisted away—before it’s too late.This interview was conducted by Dr. Miranda Melcher whose doctoral work focused on post-conflict military integration, understanding treaty negotiation and implementation in civil war contexts, with qualitative analysis of the Angolan and Mozambican civil wars. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology

On August 6, 2020, the Trump Administration issued a ban on TikTok in the United States, requiring that the owner, Beijing-based Bytedance, sell the company to American investors or shut it down. Legions of TikTokers were devastated at the possible loss of their beloved platform, and for what: a political grudge with China? American suitors like Walmart and Oracle tried to make a deal with Bytedance to keep the platform operating in the US. But then something curious happened. The Chinese government refused to let Bytedance sell TikTok on national security grounds. As it turns out, the pandemic era platform for dance challenges is a Chinese government asset.As digital technologies and social media have evolved into organizing forces for the way in which we conduct our work and social lives, the business logic that undergirds these digital platforms has become clear: we are their product. We give these businesses information about everything--from where we live and work to what we like to do for entertainment, what we consume, where we travel, what we think politically, and with whom we are friends and acquaintances. We do this willingly, but often without a full understanding of how this information is stored or used, or what happens to it when it crosses international boundaries. As Aynne Kokas argues, both corporations and governments traffic much of this data without our consent--and sometimes illegally--for political and financial gain.In Trafficking Data: How China Is Winning the Battle for Digital Sovereignty (Oxford UP, 2022), Aynne Kokas looks at how technology firms in the two largest economies in the world, the United States and China, have exploited government policy (and the lack thereof) to gather information on citizens, putting US national security at risk. Kokas argues that US government leadership failures, Silicon Valley's disruption fetish, and Wall Street's addiction to growth have fuelled China's technological goldrush. In turn, American complacency yields an unprecedented opportunity for Chinese firms to gather data in the United States and quietly send it back to China, and by extension, to the Chinese government. Drawing on years of fieldwork in the US and China and a large trove of corporate and policy documents, Trafficking Data explains how China is fast becoming the global leader in internet governance and policy, and thus of the data that defines our public and private lives.Peter Lorentzen is economics professor at the University of San Francisco. He heads USF's Applied Economics Master's program, which focuses on the digital economy. His research is mainly on China's political economy. Learn more about your ad choices. Visit megaphone.fm/adchoicesSupport our show by becoming a premium member! https://newbooksnetwork.supportingcast.fm/technology