HFA Cardio Talk

Interviewees: Associate Professor Jasper Brugts, Erasmus University Medical Centre of Rotterdam, The Netherlands; Professor John Cleland and Doctor Ross Campbell, University of Glasgow, United Kingdom of Great Britain & Northern Ireland; Doctor Jeroen Dauw AZ Saint-Lucas, Ghent, Belgium and Interviewers: Doctor Antonio Cannata, King's College London, United Kingdom of Great Britain & Northern Ireland; Doctor Jozine Ter Maaten, University Medical Centre Groningen, The Netherlands; Doctor Sotiria Liori, Attikon University Hospital, Athens, Greece; Doctor Francesca Musella, Royal Brompton Hospital, London, United Kingdom of Great Britain & Northern Ireland. This podcast discusses the results of four late breaking clinical trials presented at the Heart Failure congress 2023 in Prague, Czech. First, dr. Brugts shares the results of the MONITOR-HF trial, an open-label, randomized trial showing that haemodynamic monitoring using a cardioMEMS device, significantly improved quality of life and reduced heart failure hospitalizations in patients with moderate-to-severe heart failure. This trial was simultaneously published in the Lancet (Remote haemodynamic monitoring of pulmonary artery pressures in patients with chronic heart failure (MONITOR-HF): a randomised clinical trial - The Lancet). Second, dr. Cleland walks us through a population study from the greater Glasgow area that found that use of loop diuretics in patients without a diagnosis of heart failure was associated with poor outcomes. He consequently discusses possible explanations and clinical consequences. Third, dr. Campbell shares the results of the DAPA-RESIST trial, that found that in patients with diuretic resistance, dapagliflozin was not superior to metolazone at relieving congestion (Dapagliflozin versus metolazone in heart failure resistant to loop diuretics | European Heart Journal | Oxford Academic (oup.com)). Fourth, dr. Dauw discusses the results of the ENACT-HF trial where a strategy of natriuresis guided therapy as recommended by the HF guidelines, in an open label, sequential roll-out (first 10 patients standard of care, followed by 10-30 patients in the natriuresis arm), was shown to improve natriuresis and reduced length of hospital stay. No effect on change in congestion score or in-hospital mortality was observed. The podcast is concluded with a brief discussion of some HFA Young highlights at the congress.

With Antonio Cannata, BHF Centre of Excellence, School of Cardiovascular and Metabolic Medicine and Science. Faculty of Life Science and Medicine, King's College London, London - UK & Mauro Giacca, King's College, BHF Centre of Excellence, School of Cardiovascular and Metabolic Medicine and Science. Faculty of Life Science and Medicine, King's College London, London - UK. In this episode, Dr Cannata interviews Prof Giacca on the present and future perspectives of translational science in Heart Failure. A deep dive into the translational world with a view on the research of the next 30 years.

With Sotiria Liori, Attikon University Hospital, Athens - Greece and Ovidiu Chioncel, Emergency Institute for Cardiovascular Disease - Institut De Boli Cardiovasculare C.C.Iliescu, Bucharest; University of Medicine Carol Davila, Bucharest - Romania. In the latest episode of HFA Cardio Talk, Dr. Sotiria Liori, member of the HFA Young Committee, interviews Prof. Ovidiu Chioncel on cardiogenic shock. The podcast delves into the challenges and latest advancements in the diagnosis and management of this complex condition, providing valuable insights for clinicians and researchers. Prof. Chioncel shares his extensive knowledge on the importance of hemodynamic monitoring, the use of mechanical circulatory support devices, and other therapeutic interventions in the management of patients with cardiogenic shock. With his practical tips and tricks, Prof. Chioncel offers guidance for optimizing patient outcomes and enhancing the quality of care for this high-risk population.

With Dr. Mateusz Sokolski, Wroclaw Medical University – Poland and Prof. Finn Gustafsson, University of Copenhagen, Copenhagen - Denmark In February´s HFA Cardio Talk, Finn Gustafsson, Professor of Cardiology at the University of Copenhagen, director of the advanced heart failure, transplantation and mechanical circulatory support program at Rigshospitalet in Copenhagen, Denmark and member of the HFA Board is interviewed by Dr. Mateusz Sokolski, from Wroclaw Medical University in Poland, member of the HFA Young Committee. The podcast is related to the HFA Advanced Heart Failure course 2023, discussing its aims and rationale. Moreover, the podcast covers challenges of the disease and provides tips and tricks for the management of patients with advanced heart failure and long-term mechanical circulatory support.

With Doctor Emanuele Bobbio, Sahlgrenska University Hospital, Gothenburg - Sweden and Professor Carsten Tschoepe, Head of the Cardiomyopathy Unit – Campus Virchow German Heart Center at Charite (DZHK), Berlin - Germany and Head of the Cardiovascular Unit Immunocardiology, Berlin Institute of Health (BIH) at Charite - Germany In January's HFA Cardio Talk, Prof. Tschöpe, chair of the HFA Committee on "Cardiomyopathies, Myocarditis & Pericardial Disease", is interviewed by Dr. Bobbio, member of the HFA Young Committee, on myocarditis. This podcast will walk us through the diagnostic and therapeutic challenges of myocarditis, explaining the role of biomarkers, imaging techniques and histology in defining different subtypes of myocarditis and their prognostic and therapeutic implications. Prof. Tschöpe will also provide tips and tricks for the management of patients presenting with acute, fulminant forms of myocarditis.

With Brenda Moura, Military Hospital, Porto, and Faculty of Medicine of University of Porto - Portugal & Francesca Musella, Santa Maria della Grazie Hospital, Naples, Italy, Karolinska Institutet - Sweden In December´s HFA Cardio Talk, Dr. Francesca Musella interviews Dr. Brenda Moura on the emerging role of Patients´profiling in Heart Failure. The podcast starts with an overview of this emerging concept introduced by current HF guidelines, and then addresses the main benefits and practical repercussions of following this approach in clinical practice. In conclusion, the podcast underlies how tailoring HF medications prescription to each patient specific profile and personal tolerability may guide physicians to both HF medications prescription and up-tritation in real world scenarios.

With Daniela Tomasoni and Marianna Adamo, University of Brescia, Brescia - Italy. In November's HFA Cardio Talk, Dr. Daniela Tomasoni interviews Dr.Marianna Adamo on valvular heart disease in heart failure. The podcast starts with an epidemiological overview and then addresses the main pathophysiological mechanisms of valvular heart disease in patients with heart failure. It also discusses current recommendations regarding the treatment of mitral regurgitation. In conclusion, dr. Adamo will guide us through the new available percutaneous devices for the treatment of tricuspid regurgitation.

With Chiara Bucciarelli-Ducci (Interwiee), Royal Brompton and Harefield Hospitals, London - United Kingdom & Jessica Artico (Interwier), University College of London and Barts Heart Centre, London - United Kingdom. In this podcast, Prof Chiara Bucciarelli-Ducci, interviewed by Dr Jessica Artico, will discuss the enhanced role of Cardiovascular Magnetic Resonance in Heart Failure Patients and in the new HF guidelines. It will walk us through the advancements of this imaging technique, what can possibly change after the results of recent HF trials, as well as the role of stress CMR and the future perspectives of CMR for a HF specialist.

With Angela Massouh (Host), American University of Beirut - Lebanon and Loreena Hill (Interviewee), School of Nursing and Midwifery, Queen's University Belfast - United Kingdom In September's HFA cardio podcast Dr. Angela Massouh interviews Dr. Loreena Hill on living with a Left Ventricular Assist Device, lessons learned from around the globe. This podcast will address the lived experiences of patients living with a Left Ventricular Assist Device and their informal caregivers. It will also highlight clinical aspects of self-care and how international multidisciplinary healthcare providers can do better to assist this vulnerable group.

With Emma Louise Robinson (Host), University of Colorado, Aurora, USA. - USA and Luisa Mestroni (Interviewee), University of Colorado, Aurora, USA. In July's HFA Cardio Talk podcast, Dr Emma Robinson interviews Prof Luisa Mestroni, Director of the International Familial Cardiomyopathy Registry and Co-Director of the Molecular Genetics Program of the Cardiovascular Institute in Denver. This podcast discusses current approaches to diagnosis, treatment options and support for patients and families of inherited cardiomyopathy as well as how advances in gene editing have transformed translational research, understanding of disease mechanisms and prospects for clinical care. Relevant website