ICU Primary PrepCast
Swapnil
This podcast is about Intensive care pharmacology and physiology. This is created to prepare intensive care trainees for their primary CICM exams. However, it will be of benefit to anyone who works in intensive care and keen to acquire new knowledge or want to refresh their memory.
Episodes
Mentioned books
Jan 18, 2023 • 6min
# Epi 60 - ICU Primary Snippet 3 - Smooth muscle cell - Excitation- contraction coupling
Learn about the physiology of smooth muscle cell contraction and its differences compared to skeletal muscle. Explore the absence of t-tubules and troponin, presence of calmodulin, types of fibers, stimulation mechanisms, and cross-bridge formation during contraction. Discover how myosin light chain phosphatase aids in relaxation.
Jan 11, 2023 • 8min
# Epi 59- ICU Primary Snippet 2 - Serum Creatinine and Creatinine Clearance
The podcast discusses the significance of serum creatinine and creatinine clearance for renal function assessment, exploring factors influencing creatinine levels, the relationship with glomerular filtration rate, age-related fluctuations in creatinine levels, and challenges in estimating creatinine clearance in critical care settings.
Jan 5, 2023 • 11min
# Epi 58- ICU Primary Snippet 1 - Critical Illness and Pharmacokinetics
In this podcast, they discuss the impact of critical illness on pharmacokinetics, covering absorption, drug distribution, metabolism, clearance, and physiological states. They explore how conditions like shock and decreased GI perfusion affect drug absorption and elimination, providing insightful examples and explanations.
Sep 30, 2022 • 27min
# Epi 57 - ICU Primary - Bedside Preparation - Albumin, PRBC and Blood Grouping
Join us in this episode, where we discuss the pharmacology of IV albumin, PRBC, along with the process of blood grouping and cross-matching.
Jul 17, 2022 • 31min
# Epi 56 - ICU Primary - Bedside Preparation - Blood Thinning Agents
Join us as we discuss the pharmacology and pharmacokinetics of blood thinning agents commonly used in the Intensive Care setting. Test yourself on our fun fact questions and more.
Jun 21, 2022 • 24min
# Epi 55 - ICU Primary - Bedside preparation Part 12 - Renal Physiology
May 23, 2022 • 26min
#Epi 54 - ICU Primary - Bedside preparation Part 11 - Liver Physiology and pharmacology part 1
Explore the liver's crucial functions in storage, synthesis, metabolism, and detoxification, and its impact on drug metabolism in ICU settings. Learn about hepatic blood flow, cytochrome system, and drug clearance based on liver blood flow rates. Dive into the world of liver enzymes, focusing on the P450 enzyme system and the importance of enzymes like 3A4 and 2D6 in medication metabolism.
Apr 13, 2022 • 31min
#Epi 53 - ICU Primary - Bedside preparation Part 10 - Neuromuscular Blockade
Dive into the fascinating world of neuromuscular junctions and their significance in critical care. Discover how calcium drives muscle contraction and the role of neuromuscular blocking agents like rocuronium and cisatracurium. Learn about patient considerations and the implications of drug choice in organ failure. Unearth the history and risks of succinylcholine, along with safe monitoring techniques for neuromuscular blockade. Plus, enjoy a humorous twist with a muscle loss competition!
Mar 11, 2022 • 27min
#Epi 52 - ICU Primary - Bedside preparation Part 9 - Trauma Patient
Discover the intricacies of the coagulation cascade critical for trauma patients in the ICU. Learn about the roles of calcium, vitamin K, and how factor deficiencies affect blood clotting times. Explore the importance of ROTEM for immediate coagulation testing versus traditional methods. Uncover the historical context of INR and the unique aspects of coagulation factors. Finally, delve into tranexamic acid's vital role in trauma care, including its mechanism and impact on reducing mortality during critical situations.
Jan 22, 2022 • 25min
#Epi 51 - ICU Primary - Bedside preparation Part 8 - Elderly Patient
The challenges of treating elderly patients in critical care are examined with a focus on an 82-year-old woman in septic shock, highlighting the need for compassion. Significant cardiovascular and respiratory changes in aging are discussed, revealing how they complicate health management. The podcast emphasizes the importance of understanding pharmacokinetic alterations in older patients and explores how body composition affects drug dosing. A humorous touch is added when discussing the pros and cons of medications like Haloperidol and Olanzapine for managing hyperactive delirium.
