
No Priors: Artificial Intelligence | Technology | Startups
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Latest episodes

18 snips
Nov 30, 2023 • 26min
Open AI leadership shuffle, new diffusion models, and starting the cult of Q*
Dive into the dramatic shifts at OpenAI and what they mean for the future of tech leadership. Discover the latest advancements in video generation, like text-to-video and avatar cloning, that are reshaping the landscape. Unpack the migration from diffusion models to powerful language models and the evolving investment opportunities in AI. Plus, enjoy some lighthearted creativity with quirky branding ideas for an AI fund. It's a mix of serious insights and playful banter!

50 snips
Nov 16, 2023 • 33min
AI Agents That Reason and Code with Imbue Co-Founders Kanjun Qiu and Josh Albrecht
Discover the vision of creating AI agents capable of reasoning and coding, enhancing our productivity. The co-founders discuss the evolution of these agents, their potential for autonomy, and the challenges in building reliable systems. Learn about integrating language and code to boost AI decision-making and the rigorous research methods necessary for developing effective AI tools. The conversation also delves into evaluating AI in code generation and the future of personalized interactions in software development.

50 snips
Nov 9, 2023 • 33min
Mistral 7B and the Open Source Revolution With Arthur Mensch, CEO Mistral AI
Arthur Mensch, CEO and co-founder of Mistral AI and former DeepMind researcher, dives into the transformative power of open source in AI development. He discusses the impressive capabilities of the Mistral 7B model, the importance of optimizing algorithms, and the shift towards practical deployment in AI. Mensch also highlights Europe's emerging AI ecosystem and the need for data integrity and transparency in machine learning. With over $100M in seed financing, Mistral is set to influence the future of AI innovation.

88 snips
Nov 2, 2023 • 42min
What is Digital Life? with OpenAI Co-Founder & Chief Scientist Ilya Sutskever
Ilya Sutskever, Co-founder and Chief Scientist of OpenAI, dives into the fascinating evolution of AI and its implications. He shares insights on the early days of OpenAI and the emergent behaviors of GPT models. The conversation touches on the significance of token scarcity and the next frontiers in AI research. Sutskever discusses the critical need for AI safety and introduces the Superalignment project aimed at aligning superintelligences. He also explores the intriguing concept of digital life and its ethical implications for the future.

15 snips
Oct 26, 2023 • 36min
AI Threats & Opportunities in Cyber Security With Material Security Co-Founder Ryan Noon
Ryan Noon, co-founder of Material Security and a former leader at Dropbox and DARPA, shares insights into the rapidly evolving world of cybersecurity shaped by AI. He discusses how his experiences from high-profile email breaches inspired him to start Material Security. Ryan delves into the potential threats posed by AI hacks and the critical role government must play in internet security. He also offers invaluable advice for startup founders, emphasizing the importance of strong teams and innovative thinking in this challenging landscape.

19 snips
Oct 23, 2023 • 33min
What Google Cloud Can Teach Enterprises Developing & Rolling Out AI Tools, With Kawal Gandhi
Kawal Gandhi, Google Cloud's Lead for Generative AI, shares his extensive experience from nearly a decade in search and ads at Google. He discusses the importance of investing in AI for enterprises and reveals innovations like document generation and email assistance in Google's tools. Gandhi also dives into the challenges of model training, the role of TPUs, and the future of AI in various industries. Insights on multimodal applications and the crucial elements for successful AI adoption make this an enlightening conversation.

16 snips
Oct 12, 2023 • 43min
From App to Suite to Platform, with HubSpot's Co-Founder Brian Halligan
In this engaging conversation, Brian Halligan, co-founder of HubSpot and founder of Propeller Ventures, shares insights from his journey in transforming HubSpot from a startup into a leading CRM platform. He discusses creating the concept of ‘inbound marketing’ and its impact on marketing strategies. Brian opens up about navigating AI disruptions and his strategic approach to innovation. He also reflects on a life-threatening moment that led him to step back from his CEO role and his current focus on ocean-related climate technologies with Propeller Ventures.

24 snips
Oct 9, 2023 • 24min
Model Quality, Fine Tuning & Meta Sponsoring Open Source Ecosystem
Discover the secrets to elevating AI model performance by 10x or even 100x. Explore how fine-tuning and retrieval-augmented generation enhance functionality while addressing issues like AI hallucinations. Dive into Meta's support for the open-source ecosystem and its parallels with historic tech milestones. Plus, find out how emerging social media platforms harness AI for content creation, shaping new entrepreneurial landscapes and user experiences. Tune in to understand the future of AI and its impact on technology.

9 snips
Sep 28, 2023 • 37min
If DNA is Code, Can AI Help Write It? Scaling Cell Programming and Synthetic Biology, with Ginkgo Bioworks Co-founder and CEO Jason Kelly
Jason Kelly, co-founder and CEO of Ginkgo Bioworks and an MIT Ph.D. in Biological Engineering, dives into the intersection of AI and synthetic biology. He discusses how DNA acts as a code akin to software, highlighting innovations in protein engineering. Kelly illustrates pandemic preparedness through advancements in synthetic biology and the importance of AI in drug discovery. The conversation sheds light on corporate governance in biotech startups and the evolutionary insights that can optimize biological systems for future research.

48 snips
Sep 21, 2023 • 30min
How Replit’s AI Tools are Changing Software Development with Co-founder and CEO Amjad Masad
Amjad Masad, the CEO and co-founder of Replit, shares insights on how their AI tool, Ghostwriter, is revolutionizing software development. He explains how AI is breaking down barriers for novice programmers and enhancing coding efficiency. The conversation also delves into the future of open-source AI and its reliance on corporate support. Masad discusses innovative concepts like coding bounties and the evolving role of engineers, stressing a shift toward more adaptable models of learning in programming.
Remember Everything You Learn from Podcasts
Save insights instantly, chat with episodes, and build lasting knowledge - all powered by AI.