No Priors: Artificial Intelligence | Technology | Startups
Conviction
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Episodes
Mentioned books
120 snips
Nov 13, 2025 • 48min
How AI Will Accelerate Breakthroughs in Biotechnology with Benchling CEO Sajith Wickramasekara
Sajith Wickramasekara, co-founder and CEO of Benchling, dives deep into the intersection of AI and biotechnology. He discusses how AI agents can drastically reduce the time and cost of drug development. Sajith addresses the current state of biotech, likening it to a dot-com bust, and highlights China's rapid advancement in the pharma sector. He also shares insights on interdisciplinary collaboration between scientists and technologists, the importance of AI in improving molecule quality, and the necessity for trust in AI systems.
238 snips
Nov 6, 2025 • 42min
Meet Snowflake Intelligence: A Personalized Enterprise Intelligence Agent with Sridhar Ramaswamy
In this engaging discussion, Sridhar Ramaswamy, CEO of Snowflake and former Google Ads executive, dives into Snowflake's transformative journey towards an AI-first approach. He introduces Snowflake Intelligence, a platform designed to empower all employees with data insights. Sridhar shares insights on fostering a culture of continuous improvement and strategic partnerships with tech giants like SAP and Microsoft. He highlights the importance of product-market fit and envisions a future where AI enhances the value of data in enterprises.
223 snips
Oct 31, 2025 • 19min
The Best of 2025 (So Far) with Sarah Guo and Elad Gil
Winston Weinberg, CEO of Harvey, shares insights on using GPT-3 for legal workflows, showcasing practical AI in legal reasoning. Dr. Fei-Fei Li, a renowned AI researcher, discusses the complexities of spatial intelligence and its impact on design. Noubar Afeyan, founder of Flagship Pioneering, reflects on making entrepreneurship a systematic and scientific endeavor. Together, they explore the future of AI, its societal implications, and the ongoing transformation across various industries.
332 snips
Oct 23, 2025 • 27min
Reinventing the Developer Terminal with Warp Co-Founder and CEO Zach Lloyd
Zach Lloyd, co-founder and CEO of Warp, discusses revolutionizing the developer terminal by integrating AI agents for coding and automation. He explores the evolution of software development, highlighting the shift from hand coding to automated processes. Zach addresses philosophical questions about AI consciousness and the importance of human expertise in development roles. He also shares insights on the future of dev tools and security, emphasizing the terminal’s potential as a powerful launchpoint for agent-driven workflows.
210 snips
Oct 15, 2025 • 32min
Unlocking the Road to Energy Abundance with Base Power CEO and Co-Founder Zach Dell
Zach Dell, CEO and co-founder of Base Power, dives into the future of energy amid rising demand from AI. He shares insights on Base Power's recent $1 billion fundraise and its mission to lower electricity costs through innovative solar and battery solutions. Dell argues for a shift from centralized to distributed grid architecture and highlights the potential of batteries in transforming the energy landscape. He also discusses the importance of attracting top talent to the energy sector, emphasizing technology-driven opportunities for the future.
296 snips
Oct 9, 2025 • 37min
Humans&: Bridging IQ and EQ in Machine Learning with Eric Zelikman
Eric Zelikman, an AI researcher and founder of humans&, discusses his journey from academia to entrepreneurship. He challenges the industry’s obsession with IQ, advocating for a focus on emotional intelligence (EQ) in AI models. Eric emphasizes the importance of incorporating long-term memory and human-centered design to create collaborative systems. With insights on the current limitations of AI, he passionately argues for empowering users rather than merely automating tasks, envisioning a future where machines augment human creativity.
509 snips
Oct 4, 2025 • 58min
The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
Nikesh Arora, CEO of Palo Alto Networks and former Google executive, shares insights on AI's transformative power in business and cybersecurity. He discusses the evolution of search from ads to transaction-based models, highlighting the role of agentic AI in reshaping user experiences. Nikesh explains the pressing cybersecurity challenges posed by AI, including faster attack timelines and the rise of deepfakes. He also emphasizes leadership principles for navigating this rapidly changing landscape and expresses optimism for AI's potential to drive positive disruption.
414 snips
Sep 25, 2025 • 1h 2min
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
Joe Liemandt, founder of Trilogy and principal of Alpha School, shares his revolutionary approach to K-12 education. Imagine mastering academics in just two hours! Joe discusses replacing traditional teachers with 'Guides' and focusing on project-based workshops to ignite students' passions. He emphasizes the use of incentives to motivate learning and personalizes education to tackle varying student needs. The conversation delves into the mental health crisis in schools and the potential of AI to transform education, all while aiming to redefine what school can be.
518 snips
Sep 18, 2025 • 31min
AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
Jesse Zhang, co-founder and CEO of Decagon, previously founded Lowkey, which was acquired by Niantic. He discusses the evolution of AI customer-service agents and how Decagon's unique approach is reshaping brand-consumer interactions. Jesse shares insights on securing large enterprise clients, the impact of AI on productivity, and his philosophy on hiring talent. He also explores the future of agentic AI, emphasizing conversation-based pricing and a vision for agents communicating with each other to enhance customer experience.
444 snips
Sep 15, 2025 • 58min
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
Jared Kushner, a businessman and investor known for his role as Senior Advisor to Donald Trump, joins the discussion with Sarah Guo and Elad Gil. He shares insights about founding Affinity Partners and his AI venture, BrainCo, while emphasizing the importance of private sector skills in government. They dive into the geopolitics of AI, the potential for collaboration in the Middle East, and discuss the Abraham Accords. Kushner also addresses how his diplomatic experiences shape his investment strategies and the need for stability in the region.
