No Priors: Artificial Intelligence | Technology | Startups
Conviction
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Episodes
Mentioned books
156 snips
Sep 5, 2025 • 45min
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
Daniel Nadler, the founder of OpenEvidence, unveils how his innovative company has revolutionized medical information access, achieving a remarkable 40% adoption rate among American doctors in just 18 months. He discusses treating physicians as consumers to enhance their experience and address the enhancement of patient communication. The conversation also delves into how technology is set to reshape medical education and practice while examining motivation and recruitment philosophies that drive success in this transformative landscape.
245 snips
Aug 28, 2025 • 41min
Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
Jacob Helberg, Under Secretary of State for Economic Growth, Energy, and the Environment, discusses the transformative potential of AI in reshoring American manufacturing and enhancing supply chain security. He envisions AI as a powerful tool for productivity rather than a job-killer, promoting a tech and energy partnership in the Middle East. Helberg also tackles the path toward increased nuclear energy and highlights the importance of an open-source AI ecosystem. The conversation paints a vivid picture of the 'superintelligence century' and America’s economic evolution.
1,341 snips
Aug 21, 2025 • 42min
How Agentic AI is Transforming The Startup Landscape with Andrew Ng
Andrew Ng, co-founder of Google Brain and Coursera, discusses the transformation of startups through agentic AI with Sarah Guo and Elad Gil. They delve into how AI is reshaping successful founder profiles and the vital role of small teams. Ng emphasizes the importance of coding skills for everyone in an organization and critiques the concept of 'vibe coding.' They also explore the future of AI in engineering, the need for adaptable leadership, and the potential for models to bootstrap themselves, all while navigating the startup landscape.
355 snips
Aug 14, 2025 • 47min
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
Dylan Patel, Founder and CEO of SemiAnalysis, dives into the complex world of AI infrastructure and semiconductors. He discusses what it would take to challenge industry giant Nvidia and shares his admiration for Android technology. Predictions about OpenAI's upcoming open-source model reveal its potential ripple effects on the AI landscape. Dylan also sheds light on the evolving neocloud market, addressing sustainability and profitability challenges. Plus, he shares a thought-provoking question he would pose to Mark Zuckerberg.
454 snips
Aug 7, 2025 • 45min
The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
Matthew Prince, co-founder and CEO of Cloudflare, shares insights on the evolving internet landscape as it shifts from search engines to AI. He discusses the implications for content creators and the need for fair compensation models in an AI-driven environment. Matthew also addresses the monopolization concerns surrounding AI corporations and how Cloudflare is positioning itself to empower independent creators. The conversation highlights the importance of innovative strategies and adaptive approaches to navigate the future of content monetization.
368 snips
Jul 31, 2025 • 37min
America’s Plan to Dominate the Full AI Stack with Sriram Krishnan
Sriram Krishnan, a Senior White House Policy Advisor on AI and former tech executive, dives into the intricacies of America’s AI Action Plan. He discusses the significance of winning the AI race, emphasizing how it reflects on American cultural power. Sriram explores the critical bottlenecks in energy infrastructure and the need for America to own the full AI stack, from hardware to software. He also addresses the balance between innovation and responsible AI policies, and the implications of a technocracy in fostering technological leadership.
546 snips
Jul 24, 2025 • 33min
The Power of Quality Human Data with SurgeAI Founder and CEO Edwin Chen
Edwin Chen, Founder and CEO of SurgeAI, emphasizes the critical role of high-quality human data in AI training. He shares why he chose to bootstrap his company instead of pursuing venture capital to maintain authenticity. Discussion includes the challenges of scalable oversight and the importance of human evaluation to ensure data quality. Edwin also speculates on the implications of Meta's investment in Scale AI for SurgeAI and ponders whether an underdog can rival giants like OpenAI and Anthropic in the evolving AI landscape.
203 snips
Jul 17, 2025 • 1h 3min
Asimov: Building An Omniscient RL Oracle with ReflectionAI’s Misha Laskin
Misha Laskin, Co-founder and CEO of ReflectionAI, is a former RL lead for Gemini and a passionate advocate for user-focused AI. He discusses their latest project, Asimov, a code comprehension tool designed around customer needs. Misha dives into the challenges of scaling reinforcement learning and the significance of collaborative memory in product development. He also shares insights on the future of artificial superintelligence and reflects on the implications of Google’s decision regarding Windsurf.
295 snips
Jul 10, 2025 • 45min
Why Platforms Win and Point Solutions Fail with Rippling CEO Parker Conrad
Parker Conrad is a three-time founder and CEO of Rippling, having co-founded Zenefits. He shares valuable lessons from Zenefits' challenges and how building a robust platform is crucial for success in SaaS. Conrad discusses the often misguided advice given to founders and stresses the importance of resilience in entrepreneurship. He highlights that AI won't reduce team sizes significantly and emphasizes the need for true ownership within companies. The conversation also touches on the strategic choices founders face between remaining private or going public.
103 snips
Jul 3, 2025 • 49min
Chai-2: The AI Model Accelerating Drug Discovery with Chai Discovery Co-Founders Jack Dent and Joshua Meier
Jack Dent and Joshua Meier, co-founders of Chai Discovery, share their groundbreaking work on the Chai-2 model, revolutionizing antibody design with a remarkable 20% success rate. They discuss how AI can optimize complex molecular properties, reshaping the landscape of drug discovery. The duo emphasizes the importance of structure prediction and offers insights into how biotech professionals can leverage this innovative technology. Tune in to hear their vision for the future of drug development and the skills bioscientists should embrace to thrive in this evolving field.
