No Priors: Artificial Intelligence | Technology | Startups
Conviction
At this moment of inflection in technology, co-hosts Elad Gil and Sarah Guo talk to the world's leading AI engineers, researchers and founders about the biggest questions: How far away is AGI? What markets are at risk for disruption? How will commerce, culture, and society change? What’s happening in state-of-the-art in research? “No Priors” is your guide to the AI revolution. Email feedback to show@no-priors.com.Sarah Guo is a startup investor and the founder of Conviction, an investment firm purpose-built to serve intelligent software, or "Software 3.0" companies. She spent nearly a decade incubating and investing at venture firm Greylock Partners.Elad Gil is a serial entrepreneur and a startup investor. He was co-founder of Color Health, Mixer Labs (which was acquired by Twitter). He has invested in over 40 companies now worth $1B or more each, and is also author of the High Growth Handbook.
Episodes
Mentioned books
459 snips
Oct 4, 2025 • 58min
The Impact of AI, from Business Models to Cybersecurity, with Palo Alto Networks CEO Nikesh Arora
Nikesh Arora, CEO of Palo Alto Networks and former Google executive, shares insights on AI's transformative power in business and cybersecurity. He discusses the evolution of search from ads to transaction-based models, highlighting the role of agentic AI in reshaping user experiences. Nikesh explains the pressing cybersecurity challenges posed by AI, including faster attack timelines and the rise of deepfakes. He also emphasizes leadership principles for navigating this rapidly changing landscape and expresses optimism for AI's potential to drive positive disruption.
329 snips
Sep 25, 2025 • 1h 2min
Reinventing K-12 Education Using AI with Alpha School Principal Joe Liemandt
Joe Liemandt, founder of Trilogy and principal of Alpha School, shares his revolutionary approach to K-12 education. Imagine mastering academics in just two hours! Joe discusses replacing traditional teachers with 'Guides' and focusing on project-based workshops to ignite students' passions. He emphasizes the use of incentives to motivate learning and personalizes education to tackle varying student needs. The conversation delves into the mental health crisis in schools and the potential of AI to transform education, all while aiming to redefine what school can be.
490 snips
Sep 18, 2025 • 31min
AI Agents Talking to AI Agents: Reinventing Commerce with Decagon CEO Jesse Zhang
Jesse Zhang, co-founder and CEO of Decagon, previously founded Lowkey, which was acquired by Niantic. He discusses the evolution of AI customer-service agents and how Decagon's unique approach is reshaping brand-consumer interactions. Jesse shares insights on securing large enterprise clients, the impact of AI on productivity, and his philosophy on hiring talent. He also explores the future of agentic AI, emphasizing conversation-based pricing and a vision for agents communicating with each other to enhance customer experience.
395 snips
Sep 15, 2025 • 58min
Jared Kushner: BrainCo, Affinity Partners, and the Geopolitics of AI
Jared Kushner, a businessman and investor known for his role as Senior Advisor to Donald Trump, joins the discussion with Sarah Guo and Elad Gil. He shares insights about founding Affinity Partners and his AI venture, BrainCo, while emphasizing the importance of private sector skills in government. They dive into the geopolitics of AI, the potential for collaboration in the Middle East, and discuss the Abraham Accords. Kushner also addresses how his diplomatic experiences shape his investment strategies and the need for stability in the region.
437 snips
Sep 5, 2025 • 45min
A New Operating System for Physicians with OpenEvidence Founder Daniel Nadler
Daniel Nadler, the founder of OpenEvidence, unveils how his innovative company has revolutionized medical information access, achieving a remarkable 40% adoption rate among American doctors in just 18 months. He discusses treating physicians as consumers to enhance their experience and address the enhancement of patient communication. The conversation also delves into how technology is set to reshape medical education and practice while examining motivation and recruitment philosophies that drive success in this transformative landscape.
306 snips
Aug 28, 2025 • 41min
Reshaping America’s Economy for the Superintelligence Century with Jacob Helberg
Jacob Helberg, Under Secretary of State for Economic Growth, Energy, and the Environment, discusses the transformative potential of AI in reshoring American manufacturing and enhancing supply chain security. He envisions AI as a powerful tool for productivity rather than a job-killer, promoting a tech and energy partnership in the Middle East. Helberg also tackles the path toward increased nuclear energy and highlights the importance of an open-source AI ecosystem. The conversation paints a vivid picture of the 'superintelligence century' and America’s economic evolution.
1,526 snips
Aug 21, 2025 • 42min
How Agentic AI is Transforming The Startup Landscape with Andrew Ng
Andrew Ng, co-founder of Google Brain and Coursera, discusses the transformation of startups through agentic AI with Sarah Guo and Elad Gil. They delve into how AI is reshaping successful founder profiles and the vital role of small teams. Ng emphasizes the importance of coding skills for everyone in an organization and critiques the concept of 'vibe coding.' They also explore the future of AI in engineering, the need for adaptable leadership, and the potential for models to bootstrap themselves, all while navigating the startup landscape.
409 snips
Aug 14, 2025 • 47min
Chips, Neoclouds, and the Quest for AI Dominance with SemiAnalysis Founder and CEO Dylan Patel
Dylan Patel, Founder and CEO of SemiAnalysis, dives into the complex world of AI infrastructure and semiconductors. He discusses what it would take to challenge industry giant Nvidia and shares his admiration for Android technology. Predictions about OpenAI's upcoming open-source model reveal its potential ripple effects on the AI landscape. Dylan also sheds light on the evolving neocloud market, addressing sustainability and profitability challenges. Plus, he shares a thought-provoking question he would pose to Mark Zuckerberg.
497 snips
Aug 7, 2025 • 45min
The Shifting Value of Content in the AI Age with Cloudflare CEO Matthew Prince
Matthew Prince, co-founder and CEO of Cloudflare, shares insights on the evolving internet landscape as it shifts from search engines to AI. He discusses the implications for content creators and the need for fair compensation models in an AI-driven environment. Matthew also addresses the monopolization concerns surrounding AI corporations and how Cloudflare is positioning itself to empower independent creators. The conversation highlights the importance of innovative strategies and adaptive approaches to navigate the future of content monetization.
386 snips
Jul 31, 2025 • 37min
America’s Plan to Dominate the Full AI Stack with Sriram Krishnan
Sriram Krishnan, a Senior White House Policy Advisor on AI and former tech executive, dives into the intricacies of America’s AI Action Plan. He discusses the significance of winning the AI race, emphasizing how it reflects on American cultural power. Sriram explores the critical bottlenecks in energy infrastructure and the need for America to own the full AI stack, from hardware to software. He also addresses the balance between innovation and responsible AI policies, and the implications of a technocracy in fostering technological leadership.
