
The Matt Walker Podcast
The Matt Walker Podcast is all about sleep, the brain, and the body. Matt is a Professor of Neuroscience at the University of California, Berkeley. He is the author of the book, Why We Sleep and has given a few TED talks. Matt is an awkward British nerd who adores science and the communication of science to the public.
Latest episodes

14 snips
Jan 13, 2025 • 56min
Ask Me Anything Part 14: Sleep, AI, Space, and Superpowers
Dr. Eti Ben Simon, an expert in sleep and emotion, joins Matt Walker for a lively discussion on the intersection of AI and sleep medicine. They delve into how AI enhances sleep stage scoring and personalizes treatment plans for conditions like sleep apnea. The conversation also touches on sleep deprivation's impact on ethical decisions and the unique challenges astronauts face in microgravity. Finally, they engage in a fun thought experiment, revealing their dream sleep superpowers, from insightful dreams to sleep exchanges.

51 snips
Jan 6, 2025 • 30min
#89 - Does Catch-up Sleep Work?
Dive into the intriguing world of catch-up sleep and its surprising effects on health. A recent study reveals a potential link between weekend sleep and a reduced risk of heart disease, but there's a catch. Weekend slumber only partially recovers sleep debt, leaving critical bodily systems still affected by weekday deprivation. Discover how sleep patterns influence circadian rhythms, food intake, blood sugar levels, and deep sleep quality. The key takeaway? Prioritizing consistent, quality rest throughout the week is vital for your well-being.

29 snips
Dec 23, 2024 • 1h 3min
#88 - Sleep & Sleeping Pills with Dr. Ranji Varghese
Dr. Ranji Varghese, a medical director at the Minnesota Regional Sleep Disorders Center and a psychiatrist, discusses the fascinating world of sleep and sleeping pills. He shares his journey into sleep medicine, emphasizing the complexities of diagnosing sleep disorders. Dr. Varghese breaks down how prescription medications work on neurotransmitters and the two main classes of sleep aids, benzodiazepines and non-benzodiazepines. He highlights the risks of dependency and alarming side effects, including complex sleep behaviors, urging a careful approach to treatment.

9 snips
Dec 16, 2024 • 23min
Beneath a Highland Moon - A Sleep Story Read by Matt Walker
Take a serene journey through the Scottish Highlands, where rolling hills and sparkling lochs create a tranquil backdrop. Immerse yourself in soothing nature sounds as you wander along winding paths and breathe in fresh air. Experience a calming escape from daily stress and embrace peaceful imagery designed to help you unwind. Plus, discover the importance of mental health and therapy, with a special mention of accessible online resources for support.

56 snips
Dec 9, 2024 • 50min
#87 - Sleep, Trauma Memories, AI & Memory Hacks, with Dr. Charan Ranganath
Dr. Charan Ranganath, a renowned neuroscientist and director of the Dynamic Memory Lab, shares fascinating insights on memory. They discuss the pivotal role of sleep in consolidating memories and challenge traditional views by presenting a web of interconnected associations. Ranganath explores the effects of trauma on memory, particularly in PTSD, and highlights innovative therapies, including psychedelics, that enhance neural plasticity to reprocess traumatic memories. This engaging conversation blends neuroscience with practical approaches to improving mental health.

41 snips
Dec 2, 2024 • 56min
Ask Me Anything Part 13: Circadian Rhythms, Biphasic Sleep, Gut Health, and Animal Sleep Secrets
Explore the intriguing relationship between circadian rhythms and how they affect medication effectiveness. Discover the concept of chronotherapy, which aligns medication timing with biological cycles for better outcomes. Dive into the science of sleep, including whether some people possess a genetic advantage allowing them to thrive on less sleep. Unravel the connection between gut health and sleep, highlighting the potential benefits of probiotics. Finally, gain insights into diverse animal sleep patterns and the importance of prioritizing quality sleep for overall well-being.

7 snips
Nov 25, 2024 • 25min
#86 - Sleeping Pills & Weight Loss
Discover the intriguing link between sleep and metabolism as the conversation delves into dual orexin receptor antagonists like suvorexant. Learn how this insomnia medication may boost fat burning during REM sleep while preserving muscle mass. The discussion underscores the importance of further research and highlights a holistic approach to weight management that incorporates diet and exercise. Tune in for fascinating insights about how sleep quality influences metabolic health and potential new pathways to manage weight!

Nov 18, 2024 • 24min
Starlight Stroll - A Sleep Story Read by Matt Walker
Dive into a tranquil journey that whisks you away from the hustle and bustle of daily life. Experience serene landscapes, from enchanting moonlit valleys to peaceful sun-dappled forests. Let soothing sounds wash over you as you prepare for a restful slumber. This guided narrative helps ease your mind and invite calm, perfect for those needing to unwind. Discover the importance of mental health, coupled with a reminder to nurture it just like physical well-being.

67 snips
Nov 11, 2024 • 52min
#85 - The Power and Limits of Memory with Dr. Charan Ranganath
In a fascinating discussion with Dr. Charan Ranganath, a renowned neuroscientist and director of the Dynamic Memory Lab at UC Davis, the intricacies of memory take center stage. They explore how emotional context and neuromodulators influence what we remember or forget. Dr. Ranganath shares his journey into memory research and insights into diverse memory types. He also addresses intriguing phenomena like hyperthymesia and false memories, emphasizing that forgetting can sometimes be just as beneficial as remembering, enriching our understanding of memory’s role in life.

38 snips
Nov 4, 2024 • 1h 4min
Ask Me Anything Part 12 - Meds, Pets, Sleeping Naked, and So Much More with Dr. Eti Ben Simon
Join Dr. Eti Ben Simon, a sleep science expert who frequently collaborates with Matt Walker, as they answer a range of listener questions. They delve into how various medications can disrupt sleep and even influence dreams. The duo discusses the benefits of sleeping naked for temperature regulation and intimacy, and the surprising effects pets can have on human sleep. Explore the science behind circadian rhythms, light exposure, and even snoring, making this a comprehensive guide to optimizing your sleep!