

The Matt Walker Podcast
Dr. Matt Walker
The Matt Walker Podcast is all about sleep, the brain, and the body. Matt is a Professor of Neuroscience at the University of California, Berkeley. He is the author of the book, Why We Sleep and has given a few TED talks. Matt is an awkward British nerd who adores science and the communication of science to the public.
Episodes
Mentioned books

26 snips
Sep 8, 2025 • 45min
Ask Me Anything Part 22: Latitude, Pain Gating, Temperature & Shift Work
Discover how extreme latitudes affect sleep patterns, with practical tips for managing light exposure. Learn about the importance of aligning sleep with one's chronotype and debunk myths like the 'sleep before midnight' concept. Delve into the brain's pain suppression mechanisms during sleep and the role of significant auditory stimuli. Gain insights into temperature regulation for better sleep quality, especially for shift workers. This lively discussion blends science and personal experiences to illuminate the complexities of sleep.

74 snips
Sep 1, 2025 • 29min
#106 - Can A Sleeping Pill Help Fight Alzheimer’s?
Matt dives into the fascinating connection between sleep and Alzheimer’s, highlighting how the brain’s glymphatic system cleanses harmful proteins during deep sleep. He uncovers the dangers of chronic sleep deprivation, which can exacerbate cognitive decline. Exciting research on new sleep medications, particularly orexin antagonists, suggests they may enhance this cleaning process and offer neuroprotection. Findings indicate these drugs could potentially improve Alzheimer’s biomarkers. Prioritizing high-quality sleep emerges as a vital strategy for long-term brain health.

73 snips
Aug 25, 2025 • 1h 1min
Ask Me Anything Part 21: Sleep Debt, Snooze Button, Naps & Sleep Myths
Join two experts as they tackle the snooze button's negative impact on sleep quality and share strategies for waking up more effectively. Discover the truth behind sleep debt, the effects of eating salt at night, and the myths surrounding sleep aids like grounding sheets. They also explore how different sleep stages can influence mood and examine sleep fragmentation and its health effects. Finally, learn about innovative research linking mitochondrial stress to sleep patterns, revealing new insights into the science of sleep.

75 snips
Aug 18, 2025 • 21min
#105 - Delta Sleep Inducing Peptides
Discover the intriguing rise and fall of Delta Sleep-Inducing Peptide, once thought to be the miracle cure for insomnia. In the 1970s, researchers celebrated its ability to induce deep sleep in animals, stirring excitement across the scientific community. However, as cautionary tales unfolded, the dream of a simple solution to sleep issues faded. Hold onto your pillow as the complex nature of sleep regulation and the problems of scientific overconfidence are unveiled, reminding us there's no one-size-fits-all remedy for restful slumber.

30 snips
Aug 11, 2025 • 25min
#104 - Humans Can Navigate Like Bats
Discover the fascinating world of human echolocation, a skill once thought exclusive to animals. Learn how individuals like Daniel Kish use sound to navigate with precision. Delve into groundbreaking research showing that our brains can adapt, allowing anyone to harness echolocation through training. Explore the potential to enhance human sensory capabilities beyond traditional limits and rethink how we perceive our environment. This journey into the brain's adaptability reveals that echolocation is not just a rare gift, but a learnable skill for all.

20 snips
Aug 4, 2025 • 30min
#103 - 172 Diseases, One Hidden (Sleep) Cause?
Challenge your sleep assumptions! Discover how the consistency of your sleep schedule may outweigh the quantity. New research reveals that irregular sleep patterns can significantly increase the risk of serious diseases. Many who consider themselves long sleepers are actually suffering from poor sleep quality. Improved sleep habits could potentially prevent over 20% of cases for 92 diseases. Learn practical strategies for optimizing your sleep and understand its profound impact on health and longevity.

Jul 28, 2025 • 29min
The Dreamer's Embrace: A Sleep Story Read by Matt Walker
Immerse yourself in a soothing narrative as an elderly widower named Henry embarks on a heartfelt journey across a tranquil ocean. His sleepless nights are filled with cherished memories of his late wife, Margaret. As waves cradle him towards a dreamlike reunion, the story beautifully conveys themes of remembrance and healing. Accompanied by relaxation techniques, this peaceful voyage invites you to let go of your troubles and embrace restful slumber.

51 snips
Jul 21, 2025 • 26min
#102 - Mouth Taping
The podcast dives into the viral trend of mouth taping, designed to aid snoring and sleep apnea. It explores the benefits of nasal breathing while highlighting potential dangers for those with moderate to severe conditions. Emerging research suggests possible advantages for mild obstructive sleep apnea, but there are significant safety concerns. Matt emphasizes the risks, particularly for children and those with respiratory issues, urging listeners to seek professional guidance before experimenting. Caution is key amidst the hype!

24 snips
Jul 14, 2025 • 1h 5min
Ask Me Anything Part 20: Sleep Under the Influence
Explore the intriguing links between substances and sleep in this insightful discussion. THC may help you doze off, but chronic use can wreak havoc on your REM sleep. Caffeine's long half-life can cut deep sleep by 40%, while alcohol fragments your slumber despite initially sedating you. Discover innovative hacks like the 'nappuccino' to boost alertness. Delve into psychedelics like LSD, which disrupt sleep but lead to a REM sleep rebound, and learn how ketamine may enhance deep sleep, possibly aiding depression.

34 snips
Jul 7, 2025 • 55min
#101 - The Sleep Prescription To Better Immunity with Dr. Aric Prather
Dr. Aric Prather, a UCSF sleep expert and professor, dives into the vital connection between sleep and immune health. He explains how inadequate sleep can elevate your risk of colds and diminish vaccine effectiveness. Dr. Prather also discusses chronic inflammation as a byproduct of sleep deprivation and how it complicates age-related diseases. The conversation highlights sleep as a powerful yet often ignored tool for boosting immunity, presenting actionable strategies for improving sleep quality to enhance overall health.