The Matt Walker Podcast

Dr. Matt Walker
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44 snips
Jan 12, 2026 • 50min

Ask Me Anything Part 24: Tinnitus, SAD, Sleep Divorce, and Vaccines

Eti Ben Simon, a clinical sleep researcher, joins to share insights on sleep disorders. They dive into how sleep loss worsens tinnitus and the surprising link between seasonal affective disorder and circadian rhythms. A shocking study reveals that inadequate sleep can cut vaccine-induced antibody production by half! They also discuss the concept of 'sleep divorce' for couples and highlight the crucial role of deep sleep in building immune memory. Tips on optimizing shared sleep arrangements make for a practical, informative conversation.
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21 snips
Jan 5, 2026 • 20min

#120 - How Sleep Deprivation Hijacks Your Genetic Code

Sleep deprivation takes center stage, revealing how just one week of poor sleep can alter over 700 genes. Discover the chaos it wreaks on our circadian rhythms, pushing our bodies toward stress while promoting muscle breakdown and fat storage. Explore alarming insights on lung and hippocampal gene functions, showing how memory and respiratory health suffer. Matt highlights the ongoing molecular disruptions and the critical need for sleep, framing it as nature’s way of preserving us against deterioration.
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Dec 29, 2025 • 25min

The Midnight Bookshop: A Sleep Story Read by Matt Walker

Dive into a serene escape as you picture a cozy British bookshop hidden between old brick buildings. With calming breathing exercises, you’ll explore the shop's inviting scents and warm atmosphere. Wander through the aisles, feeling the books' spines, and settle into an armchair wrapped in a soft blanket. Take in the gentle ripples of the canal outside while embracing the tranquil sanctuary. Finally, drift into deep relaxation, letting go of tension and allowing the stillness to guide you into restorative sleep.
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37 snips
Dec 22, 2025 • 20min

#119 - Your Brain On GLP-1s

The discussion dives into the fascinating roles of GLP-1 agonists in brain health, noting their presence in memory centers. Animal studies reveal their neuroprotective effects, reducing inflammation and aiding learning. The conversation highlights the crucial link between metabolic health and sleep, suggesting a holistic approach to brain care. Limitations in translating animal findings to humans are addressed, and caution is urged regarding GLP-1s as a potential miracle cure. Ultimately, it emphasizes the intricate connections among metabolism, sleep, and brain well-being.
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53 snips
Dec 15, 2025 • 19min

#118 - A Sleep Medication to Lower the Risk of Alzheimer's

Explore the fascinating connection between sleep and Alzheimer's disease. Learn how the brain's glymphatic system cleans out harmful proteins during deep sleep. Discover the impact of just one night of poor sleep on toxic protein levels and brain aging. The discussion turns to innovative sleep medications that may help reduce these toxins. However, prioritizing natural sleep habits remains crucial for brain health. This enlightening conversation offers hope and optimism about the future of sleep medicine.
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26 snips
Dec 8, 2025 • 57min

Ask Me Anything Part 23: The Gut, Grief, Creativity, and Microsleeps

Join sleep scientist Eti Ben Simon as she delves into the intricate relationship between sleep and health. Discover how sleep deprivation affects gut health and learn about probiotics that might help. They candidly discuss the intertwining of grief and insomnia, offering strategies to improve sleep during sorrowful times. Explore how REM sleep boosts creativity and problem-solving, revealing techniques like Edison's napping method. Finally, they highlight the dangers of microsleeps and potential tech solutions to combat drowsy driving.
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24 snips
Dec 1, 2025 • 18min

#117 - Can Creatine & Exercise Overcome Sleep Deprivation?

Explore the alarming effects of sleep deprivation on our bodies. Discover how creatine acts like a 'quick charge' for the brain, restoring energy levels and cognitive function. Learn about high-intensity interval training's role in preserving glucose tolerance and mitochondrial health. Exciting studies show that both creatine and exercise can help mitigate the short-term consequences of sleeplessness, highlighting their importance as temporary aids. However, the conversation emphasizes that nothing can truly replace the restorative benefits of a good night's sleep.
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34 snips
Nov 24, 2025 • 26min

#116 - 40 Hz Brain Stimulation

Dive into the fascinating world of 40 Hz gamma rhythms, known for their role in high-order cognition. Discover how non-invasive light and sound can synchronize brain activity and potentially aid Alzheimer’s patients by encouraging immune cells to clear toxic plaques. Unpack the paradox of 40 Hz stimulation that can surprisingly promote sleepiness while improving mood and insomnia. With promising yet preliminary results, this exploration hints at a future where brain entrainment could revolutionize our approach to cognitive health.
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25 snips
Nov 17, 2025 • 17min

#115 - Sleep Deprivation for Depression

Explore the intriguing idea of using sleep deprivation as a rapid treatment for depression. Discover its surprising origins in the 1970s and the phenomenon of temporary remission followed by a high relapse rate. Uncover the neuroscientific theories behind why this method might work, including the calming of hyperactive brain regions. Dive into contrasting clinical experiences and a recent meta-analysis that questions its long-term efficacy. This discussion sheds light on the complexities of sleep's role in mental health.
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113 snips
Nov 10, 2025 • 26min

#114 - How to Boost your HRV

Dive into the fascinating world of Heart Rate Variability (HRV), where a healthy heart dances like a jazz drummer instead of ticking like a metronome. Discover how quality sleep is your secret weapon for boosting HRV, and learn why even slight sleep disturbances can hit hard. Uncover the power of exercise, particularly HIIT, to enhance heart flexibility and how stress-reducing techniques can calm the chaos. Plus, find out how substances like alcohol and caffeine can impact your heart health. It's all about nurturing that vital balance!

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