
Talk Python To Me
Talk Python to Me is a weekly podcast hosted by developer and entrepreneur Michael Kennedy. We dive deep into the popular packages and software developers, data scientists, and incredible hobbyists doing amazing things with Python. If you're new to Python, you'll quickly learn the ins and outs of the community by hearing from the leaders. And if you've been Pythoning for years, you'll learn about your favorite packages and the hot new ones coming out of open source.
Latest episodes

28 snips
Jun 6, 2025 • 1h 12min
#508: Program Your Own Computer with Python
Glyph, an independent software developer and founder of the Twisted project, dives into programming your computer with Python. He discusses tools for automating boring tasks and building desktop apps that enhance productivity. The conversation highlights using local computing power over cloud services, the complexity of integrating with Windows' APIs, and valuable Python libraries for macOS. Glyph also emphasizes ethical AI use, open-source contributions, and the importance of community collaboration in developing applications.

59 snips
Jun 2, 2025 • 1h 4min
#507: Agentic AI Workflows with LangGraph
Sydney Runkle, an open-source developer at LangChain, dives into the world of agentic AI workflows using LangGraph. She explains how integrating agentic frameworks can supercharge Python applications with large language models (LLMs). The discussion highlights the balance of AI-driven workflows, transparency in software development, and the importance of context and memory in enhancing user interactions. Runkle also shares insights on developing intelligent agents and managing application interrupts, showcasing practical examples that bridge creativity with responsibility in AI.

92 snips
May 19, 2025 • 1h 4min
#506: ty: Astral's New Type Checker (Formerly Red-Knot)
Charlie Marsh, the founder of Astral, and Carl Meyer, a Python community member and Astral employee, delve into their exciting new type checker, TY. Formerly known as Red-Knot, TY aims to revolutionize type checking in Python with superior usability and performance. They discuss the importance of type annotations for better code clarity and reveal how TY addresses common developer challenges. Additionally, they emphasize ongoing innovations in Python tooling and the need for standardization in the Python type system.

50 snips
May 13, 2025 • 1h 12min
#505: t-strings in Python (PEP 750)
Dave Peck, a freelance software developer, joins Jim Baker, a veteran in Python and Jython, and Paul Everett, head of developer advocacy at JetBrains, to discuss the upcoming T-strings feature in Python. They delve into the evolution of string formatting, highlighting the security improvements of T-strings over f-strings, especially against SQL and HTML injections. The trio explores practical applications in web development, optimized templating, and the potential of T-strings for advanced data science workflows, all while sharing insights on community collaboration in Python's growth.

149 snips
May 5, 2025 • 1h 10min
#504: Developer Trends in 2025
Join Ines Montani, co-founder of Explosion and spaCy expert, Richard Campbell of .NET Rocks fame, Gina Häußge, maintainer of OctoPrint, and Calvin Hendryx-Parker, a seasoned Pythonista, as they dissect the latest developer trends. They explore the implications of the 2024 Stack Overflow survey, the rise of AI in coding, and the importance of community in learning. Expect insights on navigating the evolving programming landscape, the balance between AI tools and traditional practices, and how unique educational backgrounds shape today's developers.

130 snips
Apr 28, 2025 • 1h 9min
#503: The PyArrow Revolution
Reuven Lerner, a freelancer and Python educator, shares insights on the transformative power of PyArrow in data science. He discusses how PyArrow's columnar format speeds up data processing and its compatibility with robust file formats. The conversation also touches on merging data importation techniques in Pandas and PyArrow, the interplay between Pandas and NumPy, and the performance benefits of modern data storage options like Parquet. Reuven emphasizes community engagement and the evolving role of large language models in programming.

40 snips
Apr 21, 2025 • 1h 4min
#502: Django Ledger: Accounting with Python
Do you or your company need accounting software? Well, there are plenty of SaaS products out there that you can give your data to. but maybe you also really like Django and would rather have a foundation to build your own accounting system exactly as you need for your company or your product. On this episode, we're diving into Django Ledger, created by Miguel Sanda, which can do just that.
Episode sponsors
Auth0
Talk Python Courses
Links from the show
Miguel Sanda on Twitter: @elarroba
Miguel on Mastodon: @elarroba@fosstodon.org
Miguel on GitHub: github.com
Django Ledger on Github: github.com
Django Ledger Discord: discord.gg
Get Started with Django MongoDB Backend: mongodb.com
Wagtail CMS: wagtail.org
Watch this episode on YouTube: youtube.com
Episode transcripts: talkpython.fm
--- Stay in touch with us ---
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Michael on Mastodon: mkennedy

51 snips
Apr 14, 2025 • 1h 1min
#501: Marimo - Reactive Notebooks for Python
Akshay Agrawal, co-founder and developer of Marimo, shares insights on creating a revolutionary reactive Python notebook that ensures your code and outputs remain perfectly in sync. He discusses challenges with traditional Jupyter notebooks, emphasizing the need for reproducibility in data science and software engineering. The conversation also touches on his experiences at Google Brain and Stanford, startup funding for open-source initiatives, and the innovative features of Marimo that enhance user experience and collaboration in programming.

65 snips
Apr 10, 2025 • 58min
#500: Django Simple Deploy and other DevOps Things
In this conversation with Eric Matthes, educator and author of Python Crash Course, listeners are introduced to Django Simple Deploy—a tool that streamlines the deployment of Django apps. Eric discusses the challenges developers face when going live, and how his project eliminates boilerplate tasks. They explore diverse hosting platforms and the evolution of deployment strategies, including the benefits of Docker and edge-based solutions. Eric emphasizes resource exploration and community engagement for developers of all skill levels.

61 snips
Mar 31, 2025 • 1h 8min
#499: BeeWare and the State of Python on Mobile
Russell Keith-Magee, a key contributor to the BeeWare project and a member of the Anaconda team, discusses the exciting advancements in creating native mobile apps using Python. He dives into the Toga GUI toolkit and the Briefcase tool for app packaging, highlighting the recent support for iOS and Android in CPython. The conversation emphasizes the user-friendly potential of Python in mobile development and explores community efforts to enhance accessibility and functionality across platforms. Russell also shares insights on the broader implications for Python's evolution in mobile environments.