Neurology® Podcast

Show description/summary:1) Serum neurofilament light chain as a biomarker for mild traumatic brain injury in contact sports2) What's Trending: Biomarker validation and precision medicine in Parkinson disease.This podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the May 9, 2017 issue of Neurology. In the first segment, Dr. Kristen Heinan talks with Dr. Pashtun Shahim about his paper on serum neurofilament light chain as a biomarker for mild traumatic brain injury in contact sports. In the next part of the podcast Dr. Alberto Espay focuses his discussion with Dr. David Standaert on biomarker validation and precision medicine in Parkinson disease. Disclosures can be found at Neurology.org.DISCLOSURES: Dr. Espay serves as Associate Editor for the Journal of Clinical Movement Disorders; serves as an editorial board member of Parkinsonism and Related Disorders and The European Neurological Journal; serves on the scientific advisory board for Solvay Pharmaceuticals, Inc. (now Abbvie), Chelsea Therapeutics International, Ltd., Teva Pharmaceutical Industries Ltd., Impax, Merz Pharmaceuticals, Inc., Pfizer Inc, Solstice Neurosciences, Eli Lilly and Company, ACADIA Pharmaceuticals, Inc. and USWorldMeds; is a consultant for Chelsea Therapeutics International, Ltd., Solvay Pharmaceuticals, Inc. (now Abbvie), ACADIA Pharmaceuticals, Inc., Cynapsus and Lundbeck, Inc; receives royalties for publications of books from Lippincott, Williams & Wilkins and Cambridge University Press; serves on the speakers' bureau of UCB, Teva Pharmaceutical Industries Ltd., American Academy of Neurology and Movement Disorders Society; receives research support from the CleveMed/Great Lake Neurotechnilogies, Michael J. Fox Foundation and the NIH.Dr. Standaert serves on scientific advisory boards for the American Parkinson Disease Association; serves on the DSMB for Shire/Biropharma; received honoraria from the Movement Disorder Society and Georgia Regents University; is Associate Editor for Movement Disorders; receives publishing royalties for Movement Disorders (McGraw-Hill Publishers, 3rd ed.); consulted for Serina Therapeutics, Kirchner Group, Teva Neuroscience, Abbvie, and the U.S. Attorney's Office; receives research support from Abbvie, Acerta Pharmaceuticals, Ceregene, Quintiles, NIH, Alabama Department of Commerce, American Parkinson Disease Association, Michael J. Fox Foundation for Parkinson Research, Bachmann-Strauss Dystonia & Parkinson Foundation, and the Dystonia Medical Research Foundation.All other participants report no disclosures.

We are producing and releasing 4 special podcast interviews this month dedicated to responsible opioid prescribing. We are doing this largely as a response to the ongoing opioid epidemic in the U.S. and around the world. In Special Podcasts 1 and 2, Dr. Ted Burns interviews Dr. Charles Argoff from Albany Medical College in New York. Many state boards in the U.S. are now requiring a few hours of CME for responsible opioid prescribing practices, and these podcasts may be eligible for a total 2 hours of Category 1 CME, however please check with your individual U.S. state Board of Medicine mandates. Regardless of CME, we felt these topics deserved covering and we hope you check out all four episodes and find them helpful and informative.

We are producing and releasing 4 special podcast interviews this month dedicated to responsible opioid prescribing. We are doing this largely as a response to the ongoing opioid epidemic in the U.S. and around the world. In Special Podcasts 1 and 2, Dr. Ted Burns interviews Dr. Charles Argoff from Albany Medical College in New York. Many state boards in the U.S. are now requiring a few hours of CME for responsible opioid prescribing practices, and these podcasts may be eligible for a total 2 hours of Category 1 CME, however please check with your individual U.S. state Board of Medicine mandates. Regardless of CME, we felt these topics deserved covering and we hope you check out all four episodes and find them helpful and informative.

Show description/summary:1) Outcome of intracerebral hemorrhage associated with different oral anticoagulants2) Neurology Resident & Fellow section yearly recruitmentThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the May 2, 2017 issue of Neurology®. In the first segment, Dr. Andrew Southerland talks with Dr. David Werring about his paper on outcome of intracerebral hemorrhage with oral anticoagulants. Then, for our "What's Trending" feature of the week, Dr. Southerland focuses his interview with Dr. John Millichap on recent updates regarding the Neurology Resident & Fellow section. Disclosures can be found at Neurology.org. DISCLOSURES: Dr. Werring has served on scientific advisory boards for Allergan, Bayer, IXICO, and Amgen; has received speaker honoraria from Bayer; has served on the editorial board of the European Stroke Journal; has received publishing royalties from Cambridge University Press; has been a consultant for Ixico Ltd.; and has received research support from Pfizer, the Department of Health/Higher Education Funding Council For England, the Stroke Association/British Heart Foundation, and the Rosetrees Trust.Dr. Southerland serves as Podcast Deputy Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: "Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;" and gave legal expert review. Dr. Millichap has received speaker honoraria from Invitae; serves on the editorial board for Neurology and Pediatric Neurology Briefs; receives publishing royalties from BMJ Best Practice and UpToDate; and has received research support from UCB Pharma, Thrasher Research Fund, and Citizens United for Research in Epilepsy.

Show description/summary:1) Epidemiology and Prognosis of Mild Traumatic Brain Injury in Returning Soldiers: A Cohort Study2) What's Trending: Alemtuzumab treatment and multiple sclerosisThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 18, 2017 issue of Neurology. In the first segment, Dr. Michael Jaffee talks with Dr. Karen Schwab about her paper on mild traumatic brain injury in returning soldiers. For our "What's Trending" feature of the week, Dr. Mark Keegan talks with Dr. Gavin Giovannoni about his paper on alemtuzumab treatment and multiple sclerosis. For more information on traumatic brain injury services for active duty military and veterans, please visit the Defense and Veterans Brain Injury Center website at http://dvbic.dcoe.mil. Disclosures can be found at Neurology.org.DISCLOSURES: Dr. Jaffee serves on the scientific advisory board for Neurohabitation, Inc., and has received research support from the Florida State Department of Elderly Affairs.Dr. Schwab receives research support from Congressionally Directed Medical Research Programs (Grant #W81XWH-08-2-0105).Dr. Keegan serves on the editorial board for Multiple Sclerosis and Related Disorders; served as eMedicine Chief Editor from 2009 to 2015; receives publishing royalties for Common Pitfalls in Multiple Sclerosis and CNS Demyelinating Diseases: Case-Based Learning (Cambridge University Press 2016); consults for Novartis, Bristol Meyers Squibb, and Bionest; and received research support from Biogen for the ARISE study.Dr. Giovannoni consulted and served on scientific advisory boards for Biogen-Idec, Fiveprime, Genzyme, GW Pharma, Ironwood, Merck-Serono, Novartis, Roche, Sanofi-Aventis, Synthon BV, Teva, Vertex Pharmaceuticals, Abbvie, and Canbex; receives speaker honoraria from Biogen-Idec, Genzyme, GW Pharma, Merck-Serono, Novartis, Roche, and Teva Pharmaceuticals; serves as an editor for Multiple Sclerosis and Related Disorders; served on speaker's bureaus for Novartis and Teva; and received research support from Genzyme and Merck.

Show description/summary:1) Practice guideline summary: Sudden unexpected death in epilepsy 2) What's Trending: 21st Century Cures ActThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 25, 2017 issue of Neurology. In the first segment, Dr. Andrew Schomer interviews Dr. Cynthia Harden about the AAN practice summary guideline on sudden unexpected death in epilepsy (SUDEP). Then, for our "What's Trending" feature of the week, Dr. Jason Crowell talks with Dr. Nicholas Johnson about the 21st Century Cures Act. Disclosures can be found at Neurology.org.DISCLOSURES: Dr. Johnson serves as Associate Editor for Neurology: Genetics; receives research support from Ionis Pharmaceuticals, Biogen Idec, Balerion Therapeutics, Cytokinetics, Acceleron, NINDS (grant 1K23NS091511-01), Muscular Dystrophy Association, and Myotonic Dystrophy Foundation; and consults for AMO Pharma and AveXis. Dr. Schomer, Harden, and Crowell report no disclosures.

Show description/summary:1) Intracerebral hemorrhage location and outcome among clinical trial participants 2) What's Trending: childhood amnesiaThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 11, 2017 issue of Neurology. In the first segment, Dr. Andrew Schomer talks with Dr. Craig Anderson about his paper on intracerebral hemorrhage location and outcome among clinical trial participants. Then, for our "What's Trending" feature of the week, Dr. Ted Burns talks with Dr. Cristina Alberini about her paper on childhood amnesia. Disclosures can be found at Neurology.org.DISCLOSURES: Dr. Anderson served on scientific advisory boards for Astra Zeneca and Medtronic; receives honoraria and travel funding from Takeda China and Boehringer Ingelheim; serves on editorial boards for Stroke, Cerebrovascular Diseases, and International Journal of Stroke; and receives research support from the National Medical Research Council of Australia (grants 1052555, 1020462, and 1081356).Dr. Alberini serves on editorial boards for Neural Plasticity, Journal of Cell Science, Frontiers in Neuroscience, Neurobiology of Learning and Memory, Behavioral Neuroscience, Learning and Memory, European Brain Research Institute (EBRI) International Scientific Council (ISC), and Cellular and Molecular Neuroscience of Hippocampus. Dr. Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc. All other participants report no disclosures.

The first interview is with Dr. Ted Burns and Dr. Merit Cudkowicz on the topic of ALS. This interview was part of the January 31, 2017 episode. The second interview, from October 25, 2016, is with Dr. Nath on HERV-K and ALS. In the third and final interview, originally released on February 28, 2017, Dr. Burns speaks with Dr. Richard Finkel about nusinersen and spinal muscular atrophy.

Show description/summary:1) Reduction in Time to Treatment in Pre-hospital Telemedicine Evaluation and Thrombolysis2) What's Trending: gut microbiota regulate motor deficits and neuroinflammation in Parkinson diseaseOur podcast has changed to a two-segment format! Enjoy two in-depth interviews each week, starting with one featured article from the Neurology® family of journals followed by an interview on a trending topic or on a notable article from Neurology Today.This podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the April 4, 2017 issue of Neurology. In the first segment, Dr. Andy Southerland interviews Dr. Shazam Hussain about his paper on time-to-treatment in pre-hospital telemedicine evaluation and thrombolysis. Then, for our "What's Trending" feature of the week, Dr. Alberto Espay talks with Dr. Sarkis Mazmanian about his paper on how gut microbiota regulate motor deficits and neuroinflammation in Parkinson Disease. Disclosures can be found at Neurology.org.DISCLOSURES: Dr. Southerland serves as Podcast Deputy Editor for Neurology; receives research support from the American Heart Association-American Stroke Association National Clinical Research Program, American Academy of Neurology, American Board of Psychiatry and Neurology, Health Resources Services Administration and the NIH; has a provisional patent application titled: "Method, system and computer readable medium for improving treatment times for rapid evaluation of acute stroke via mobile telemedicine;" and gave legal expert review.Dr. Hussain served on scientific advisory boards for pulsar neurovascular, penumbra, Inc., and Prolong Medical.Dr. Espay serves as Associate Editor for the Journal of Clinical Movement Disorders; serves as an editorial board member of Parkinsonism and Related Disorders and The European Neurological Journal; serves on the scientific advisory board for Solvay Pharmaceuticals, Inc. (now Abbvie), Chelsea Therapeutics International, Ltd., Teva Pharmaceutical Industries Ltd., Impax, Merz Pharmaceuticals, Inc., Pfizer Inc, Solstice Neurosciences, Eli Lilly and Company, ACADIA Pharmaceuticals, Inc. and USWorldMeds; is a consultant for Chelsea Therapeutics International, Ltd., Solvay Pharmaceuticals, Inc. (now Abbvie), ACADIA Pharmaceuticals, Inc., Cynapsus and Lundbeck, Inc; receives royalties for publications of books from Lippincott, Williams & Wilkins and Cambridge University Press; serves on the speakers' bureau of UCB, Teva Pharmaceutical Industries Ltd., American Academy of Neurology and Movement Disorders Society; receives research support from the CleveMed/Great Lake Neurotechnilogies, Michael J. Fox Foundation and the NIH.For full disclosures, please contact Dr. Mazmanian directly at sarkis [at] caltech.edu.

1) Early Decompressive Craniectomy for Malignant Cerebral Infarction: Meta-analysis and Clinical Decision Algorithm2) What's Trending: Update on the Resident and Fellows section 3) Topic of the Month: Brain tumors - gliomasThis podcast begins and closes with Dr. Robert Gross, Editor-in-Chief, briefly discussing highlighted articles from the March 28, 2017 issue of Neurology. In the first segment, Dr. Bryan Eckerle talks with Dr. Bradley Molyneaux and Dr. Christopher Streib about their Neurology® Clinical Practice paper on early decompressive craniectomy for malignant cerebral infarction. Dr. Ted Burns talks with Dr. Roy Strowd about recent updates regarding the Neurology® Resident & Fellows section for our "What's Trending" feature of the week. In the next part of the podcast, Dr. Kait Nevel focuses her interview with Dr. David Schiff on gliomas. Disclosures can be found at Neurology.org. DISCLOSURES:Dr. Molyneaux has received research support from Remedy Pharmaceuticals, Inc.Dr. Streib has served on the Institute for Clinical Systems Improvement (ICSI) Stroke Guidelines Committee (no reimbursement).Dr. Burns serves as Podcast Editor for Neurology®; and has received research support for consulting activities with UCB, CSL Behring, Walgreens and Alexion Pharmaceuticals, Inc. Dr. Strowd serves on the editorial board of Neurology (Resident & Fellow section); and has received research support from the Wake Forest School of Medicine Center for Translational Sciences Award, the KL2 Career Development Award, and the American Academy of Neurology.Dr. Schiff has served on the scientific advisory boards of Genetech, Celldex, Orbus, and Vascular Biogenics Oxigene; has received travel funding/speaker honoraria from Merck; serves on the editorial boards of Neurology, Neurosurgery, Neuro-Oncology, and Lancet Neurology; receives publishing royalties from UpToDate, and has been a consultant for Cavion.All other participants report no disclosures.