Nucleate Podcast

Sean McClain, Founder and CEO of AbSci, discusses using AI for drug development, the fusion of engineering and biology, the power of mentors in entrepreneurship, fostering diverse perspectives in leadership teams, and the challenges of pivoting to generative AI for antibodies.

[02:15] Bobby Gaspar’s background[05:10] The science of haematopoietic stem cell therapy[12:30] Spinning out Orchard Therapeutics[21:15] Reverse partnerships with pharma[25:55] Balancing regulatory compliance and innovation[29:45] Value based payments [35:15] Recent approval of Casgevy and gene therapy regulation[39:45] Failures in a biotech’s journey[43:00] Impact and meaning in therapeutics companies

On this episode of the podcast, Signal hosts Michael Retchin and Ursule Demael interview Prof. Lee Cronin from Chemify. Lee Cronin is a Professor at the University of Glasgow, where he leads a research group focused on digital chemistry, automating chemical synthesis and origin of life. Lee Cronin is also the co-founder and CEO of Chemify, a startup advancing digitization and robotics for chemistry. In this episode, we discuss the idea of building a search engine for chemistry, the founding story of Chemify, and important differences between running an academic lab and a successful Series A stage startup. Lee Cronin shares how unique aspects of his personality and persistence were critical to build Chemify. Lee Cronin is an outspoken scientist, who is active on Twitter and has appeared on the Lex Fridman podcast, making for a fascinating and engaging episode!

Trevor talks about his inspirations for his career path [1:22]How to choose his PhD advisor and lab [3:51]Career trajectory, handling moments of uncertainty, and learning from mistakes [9:56]Trevor discovered a niche at the intersection of biology, physics, and computer science [11:54]Mammoth is uniquely positioned as an innovative science-focused company that delivers for patients [18:36]Trevor's key leadership advice he has learned as a CEO [24:43]CRISPR technology has the potential to revolutionize healthcare [27:55]

Show NotesTony's career foundations as an academic scientist at MIT and early inspiration for entrepreneurship  [0:43]Engaging in entrepreneurial groups shaped Tony's early career [07:10]Tony's inspiration to co-found Petri [11:38]Pillar is rethinking the approach to biotech investing [25:21]Pillar's investment thesis [30:34]Tony's advice to a PhD student who is considering industry and entrepreneurship [35:59]

What sparked Dr. Goodman’s interest in biotech (0:00)Deciding to pivot from academia to venture capital (3:45)Failing fast and applying that mindset to science (9:44)Transitioning from academia to a start up (14:44)Advice for aspiring technical founders (20:03)Becoming an investor at MPM Capital (30:24)MPM’s investment thesis in oncology. (40:14)

Introducing Nucleate Signal, a celebration of the next generation of biotech leaders. In this episode, host Emmanuella Nnuji-John is joined by guest Cheri Ackerman, the co-founder and CEO of Concerto Bioscience.

In this episode, host Jingyi Liu and Sam Kessel are joined by guest Martin-Immanuel Bittner, the co-founder and CEO of Arctoris.