CMAJ Podcasts

Allopurinol hypersensitivity syndrome (AHS) affects approximately 1 in 1,000 patients prescribed allopurinol, with reported mortality rates between 20% and 25%. The risk of AHS is nearly 100 times higher in carriers of the HLA-B*58:01 allele than in noncarriers. Populations with a high allele frequency include Han Chinese (6%-8%), Korean (12%), and Thai (6%-8%) people.In this episode, Drs. Wid Yaseen and Jonathan Zipursky discuss their paper published in CMAJ, titled "Five things to know about…allopurinol hypersensitivity syndrome". Dr. Jonathan Zipursky is a general internist, clinical pharmacologist, and clinician scientist at Sunnybrook Health Sciences Centre. Dr. Yaseen is a second-year internal medicine resident physician at the University of Toronto. They argue that the syndrome's frequency is often underestimated and emphasize the importance of genetic testing in susceptible populations.Next, Dr. David Juurlink broadens the discussion beyond allopurinol to describe other common medications whose effectiveness and safety are significantly influenced by genetic predispositions. Dr. Juurlnk is a staff internist and head of division of clinical pharmacology and toxicology at Sunnybrook Health Sciences Centre in Toronto. He is also a medical toxicologist at the Ontario Poison Centre.  He explores the need for expanded genetic testing to protect patients and ensure proper dosing.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Fragility fractures are a major health concern for older adults and can result in disability, admission to hospital and long-term care, and reduced quality of life. The Canadian Task Force on Preventive Health Care guideline published in CMAJ provides evidence-based recommendations on screening for primary prevention of fragility fractures.In this special episode of the CMAJ podcast, CMAJ editor-in-chief Dr. Kirsten Patrick speaks to Dr. Roland Grad, a family physician and an author of the new guideline, about the evidence reviews conducted by the task force, the main points of the new guideline, and how family doctors can use it in practice. The guideline recommends screening females over 65 using the FRAX tool without bone mineral density (BMD) as a risk assessment first strategy. Dr. Grad emphasizes the importance of shared decision making, which can be facilitated using the Fragility Fracture Decision Aid, which incorporates the FRAX tool. This online, interactive tool helps  guide discussions with patients about their fracture risk and potential benefits of preventive treatment.Links to resources mentioned in the interview:Canadian Task Force on Preventive Healthcare guidelineFragility Fractures Clinician InfographicFragility Fracture Decision Aid Article in Journal of Systematic ReviewsComments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

An estimated 23%-45% of patients undergoing major surgery have anemia, with the most common causes being iron deficiency anemia and anemia of inflammation or chronic disease.In this episode, Drs. Mojola Omole and Blair Bigham speak with Dr. Clarissa Skorupski and Dr. Yulia Lin, two authors of the practice paper in CMAJ, "Five things to know about preoperative anemia in major elective surgery." Dr. Skorupski is a third-year internal medicine resident at the University of Toronto, and Dr. Yulia Lin is the division head of transfusion medicine and tissue bank at Sunnybrook Health Sciences in Toronto. They highlight the high prevalence of preoperative anemia, its adverse outcomes, and the importance of targeting a preoperative hemoglobin level of 130 g/L for both sexes.Next, Drs. Bigham and Omole take a critical look at the WHO guideline which sets a lower hemoglobin threshold of 120 g/L for female bodies. They speak with Dr. Michelle Sholzberg, the head of hematology-oncology and the director of the Hematology Oncology Clinical Research Group at St. Michael's Hospital in Toronto. Dr. Sholzberg argues that the WHO's sex-based hemoglobin thresholds for diagnosing anemia perpetuate structural discrimination in medicine, as they normalize anemia in females and are based on outdated data with a high risk of bias. Dr. Sholzberg describes how the policies and clinical practices following the biased thresholds may impact health-related quality of life, cognitive function, and the health of pregnant individuals and their babies.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Many patients report their symptoms of endometriosis are often dismissed by healthcare providers as “normal” dysmenorrhea. This worldwide trend results in delays to diagnosis that are estimated to range from 6 to 11 years from symptom onset. On this episode, Drs. Bigham and Omole speak with Dr. Catharine Allaire, a clinical professor at UBC's Department of Obstetrics and Gynaecology and co-author of the review in CMAJ entitled “Diagnosis and management of endometriosis”. Dr. Allaire discusses the challenges and delays in diagnosing endometriosis, its symptoms and causes, and the different varieties of the condition. She also explains the role of imaging in diagnosing endometriosis and how it can be managed through various treatment options from hormone therapies to surgery.Drs. Bigham and Omole also speak with Hannah Robinson, an emergency department nurse who has struggled with endometriosis for seven years. She describes the challenges she faced receiving a diagnosis and accessing care.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Clinicians may find diagnosing polyneuropathy challenging due to the vague and insidious onset of symptoms. Identifying signs consistent with polyneuropathy and determining which investigations to conduct and when to be concerned can be daunting.Polyneuropathy involves simultaneous dysfunction of multiple peripheral nerves, with the most common form being distal symmetric polyneuropathy. Symptoms primarily occur distally, mainly at the bottom of the feet, and progress proximally. Sensory symptoms are more frequent than motor symptoms and signs. Patients with distal symmetric polyneuropathy may experience neuropathic pain, impairments in walking, and distal motor function, significantly impacting their quality of life.Dr. Ario Mirian, a fifth-year neurology resident at the University of Western Ontario's Schulich School of Medicine and Dentistry, is the lead author of a review article in CMAJ entitled "Diagnosis and management of patients with polyneuropathy". In this episode, Dr. Mirian presents a practical approach to diagnosing and managing polyneuropathy while highlighting 'red flags' that should prompt clinicians to investigate potentially serious underlying causes, such as malignancy or vasculitis.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

The use of electric scooters (e-scooters) has witnessed a substantial surge globally.However, the presence of these motorized vehicles on sidewalks poses a significant risk to pedestrians. A recent practice paper published in CMAJ describes the case of a 68-year-old woman who suffered serious injuries while walking on a city sidewalk after being hit by an e-scooter traveling at approximately 30 km/h. While the authors of the paper recognize e-scooters as a popular, efficient and green form of transportation, they argue effective policies are needed to mitigate risks associated with their use. On this episode, Drs. Blair Bigham and Mojola Omole speak with Zach Williams, the director of policy and government partnerships and Jamie Perkins the director of communications for  Superpedestrian. Superpedestrian is an e-scooter company that spun off from the MIT Sensible City Lab. They discuss the necessary changes to urban infrastructure as well as the responsibilities of e-scooter providers to ensure safety for riders and pedestrians.The discussion then shifts to Catherine McKenney, a former Ottawa city councilor and mayoral candidate, who proposed substantial investments in biking infrastructure during their campaign. They argue that debates about safe urban transit have become too polarized and that it is not a matter of being for or against cars, but rather about finding effective solutions to make transportation safe and efficient for all users.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Uptake of the SARS-CoV-2 vaccine for children aged 5–11 years has been lower than anticipated in Canada. Although research has explored parental intentions toward SARS-CoV-2 vaccination for children, the drivers of parents’ decisions to seek vaccination for their children - or not -  have not been studied in-depth. A research paper published in CMAJ,  entitled Parents’ perspectives on SARS-CoV-2 vaccinations for children: a qualitative analysis, sought to explore parents’ decision-making. It was a collaboration between physicians, social scientists and research scientists. On this episode, four of the paper’s authors discuss their findings with hosts, Drs. Omole and Bigham. They emphasize the importance of existing trusting relationships between parents and their primary care providers when it comes to making difficult healthcare decisions for children.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Early in the COVID-19 pandemic, Ontario saw a 5600% increase in virtual visits to health care practitioners, while in-office visits decreased by 79% from the previous year. In 2018, only 4% of family physicians in Canada were offering video visits while, at the peak of the pandemic, about 80% of primary care visits were being delivered virtually in Ontario.Media reports at the time suggested patients were substituting emergency department (ED) visits when in-person consultations were unavailable, leading to additional strain on already stretched ED resources.A research paper published in CMAJ looked at whether this shift in care was in fact taking place. Dr. Hemant Shah is an internal medicine physician and hepatologist at Toronto General Hospital and co-author of the study entitled Association between virtual primary care and emergency department use during the first year of the COVID-19 pandemic in Ontario, Canada.On today’s episode, Dr. Shah discusses the study’s surprising findings with hosts Dr. Blair Bigham and Dr. Mojola Omole.  Drs Omole and Bigham then speak with Toni Leamon, the CMA’s patient voice chair, a member of CMA's Virtual Care Taskforce and a co-author of the CMA's Virtual Care Companion for Patients. She offers the patient’s vision of high quality virtual care.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Migraine is a common condition that affects around 12% of adults, with a higher prevalence in women (18%) than men (6%). Global burden of disease estimates in 2019 found migraine to be the leading cause of disability in women aged 15-49 years and the second leading cause of disability overall. On this episode, Drs. Mojole and Bigham interview three authors of two review articles on the topic published in CMAJ, which focus on diagnosis, acute treatment and prevention of migraine.  Dr. Velina Tzankova is a neurology resident at the University of Toronto; Dr. Werner Becker is a neurologist and the founding director of the Calgary Headache Assessment and Management Program, and currently professor emeritus in the Department of Clinical Neurosciences at the University of Calgary; and Dr. Tommy Chan is a neurologist and director of John H. Kreeft Headache Clinic at University Hospital in London, Ontario. As well, Drs. Bigham and Omole interview two women who have battled severe migraine since childhood: psychologist, Dr. Shanthy Edward, and med student, Zikra Awosanmi. They discuss the impact migraine headaches have had on their lives, the challenges they have faced accessing adequate treatment, and their thoughts on what physicians could better understand about this disabling condition.Comments or questions? Text us.Join us as we explore medical solutions that address the urgent need to change healthcare. Reach out to us about this or any episode you hear. Or tell us about something you'd like to hear on the leading Canadian medical podcast.You can find Blair and Mojola on X @BlairBigham and @DrmojolaomoleX (in English): @CMAJ X (en français): @JAMC FacebookInstagram: @CMAJ.ca The CMAJ Podcast is produced by PodCraft Productions

Suzie Goulding, founder of COVID Long Haulers Canada, shares her poignant journey with long COVID, shedding light on the debilitating fatigue and complex symptoms she faced. General internist Kieran Quinn discusses the nuances of diagnosing this condition, emphasizing clinical judgment over extensive tests. They explore the impact of treatments during acute COVID-19 on long COVID development and highlight the importance of understanding and support from the medical community. Their insights aim to reshape healthcare responses to this ongoing crisis.