Podcast Notes Playlist: Latest Episodes

Invest Like the Best: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- My guest today is David Senra. David is the host of Founders podcast and a dear friend. This is our third time doing Invest Like the Best together and we have conversations like this one all the time. In today’s episode, David distills wisdom from 400 entrepreneur biographies into a single word: focus. He reveals why exceptional builders like Todd Graves and James Dyson create billion-dollar empires through obsessive dedication to simple ideas—whether perfecting chicken fingers or designing vacuum cleaners—while rejecting conventional growth timelines and investor pressure. David challenges us all to find the one thing we’d pursue even without recognition or reward, or what I like to call your life’s work. We discuss the concept of “anti-business,” raising capital as a founder, and decades-long commitment. Please enjoy this discussion with David Senra.  For the full show notes, transcript, and links to mentioned content, check out the episode page here. ----- This episode is brought to you by Ramp. Ramp’s mission is to help companies manage their spend in a way that reduces expenses and frees up time for teams to work on more valuable projects. Go to Ramp.com/invest to sign up for free and get a $250 welcome bonus. –  This episode is brought to you by AlphaSense. AlphaSense has completely transformed the research process with cutting-edge AI technology and a vast collection of top-tier, reliable business content. Invest Like the Best listeners can get a free trial now at Alpha-Sense.com/Invest and experience firsthand how AlphaSense and Tegus help you make smarter decisions faster. – This episode is brought to you by Ridgeline. Ridgeline has built a complete, real-time, modern operating system for investment managers. It handles trading, portfolio management, compliance, customer reporting, and much more through an all-in-one real-time cloud platform. Head to ridgelineapps.com to learn more about the platform. ----- Editing and post-production work for this episode was provided by The Podcast Consultant (https://thepodcastconsultant.com). Show Notes: (00:00:00) Welcome to Invest Like the Best (00:05:43) The Essence of Focus in Entrepreneurship (00:09:20) The Value of Long-Term Commitment (00:17:41) The Importance of Simplicity and Mastery (00:37:11) The Miracle of Entrepreneurship (00:44:56) James Dyson's Journey to Success (00:47:03) The Importance of Passion in Business (00:49:12) Critique of Modern Consumerism (00:52:18) The Value of Craftsmanship (00:56:36) The Drive for Excellence (01:04:06) The Importance of Hiring Top Talent (01:09:54) Creative Financing Strategies (01:19:35) Defining a Founder

Doctor's Farmacy with Mark Hyman, MD: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Cutting-edge medical advances are unlocking new ways to slow aging and enhance health. Plasmapheresis removes harmful inflammatory molecules, toxins, and cellular waste from plasma, helping to reduce biological aging and improve resilience. Muse cells, a powerful form of stem cell therapy, show promise in regenerating tissue and treating complex conditions like ALS and stroke. And peptides—small, naturally occurring signaling molecules—support healing, immune balance, and cellular repair, offering practical tools for longevity and optimized health. In this episode, I talk with Dr. Darshan Shah, Dr. Adeel Khan, and Dr. Edwin Lee about medical advancements that are the ultimate longevity biohacks. Dr. Darshan Shah is a board-certified surgeon, longevity medicine expert, author, and founder of Next Health—the world’s largest Health Optimization and Longevity clinic. He has performed over 20,000 surgical procedures and advised thousands on extending healthspan and lifespan. A prodigy in medicine, Dr. Shah earned his MD at 21 and trained at the Mayo Clinic. He has since launched multiple health ventures, authored a book, and patented medical devices. Committed to ongoing learning, he holds alumni status at Harvard Business School and Singularity University. Dr. Shah is a sought-after speaker on health and longevity. Dr. Adeel Khan, M.D. is a cell and gene therapy specialist with a visionary approach that is changing the way we perceive healthcare worldwide. Khan has cemented his reputation as a regenerative medicine expert and a driven entrepreneur. Dr. Edwin Lee is a board-certified endocrinologist, author, and international speaker specializing in hormonal balance, regenerative, and functional medicine. He founded the Institute for Hormonal Balance in Orlando in 2008 and completed fellowships in Critical Care and Endocrinology at the University of Pittsburgh. Dr. Lee is the lead investigator of an IRB-approved senolytic study exploring compounds like Dasatinib, Quercetin, and Fisetin, and recently published the first human trial using BPC157 for knee pain. He is an assistant professor at the University of Central Florida College of Medicine, co-founder of the Clinical Peptide Society, and founder of SavePeptides.org. His latest book is The Fountain of Youth with Peptides. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: This Breakthrough Blood Therapy Could Add Years To Your LifeStem Cells & Peptides: The Secret to Reversing Chronic Pain and Aging?How Peptides Enhance Healing and Longevity

My First Million: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Episode 703: Sam Parr ( https://x.com/theSamParr ) and Shaan Puri ( https://x.com/ShaanVP ) talk to George Mack ( https://x.com/george__mack ) about high agency.  — Links: • Steal Sam's guide to turn ChatGPT into your Executive Coach: https://clickhubspot.com/wec • High Agency - https://www.highagency.com/  • Nick Mowbray episode - https://www.youtube.com/watch?v=4pHcxoZ0j9A  — Check Out Shaan's Stuff: Need to hire? You should use the same service Shaan uses to hire developers, designers, & Virtual Assistants → it’s called Shepherd (tell ‘em Shaan sent you): https://bit.ly/SupportShepherd — Check Out Sam's Stuff: • Hampton - https://www.joinhampton.com/ • Ideation Bootcamp - https://www.ideationbootcamp.co/ • Copy That - https://copythat.com • Hampton Wealth Survey - https://joinhampton.com/wealth • Sam’s List - http://samslist.co/ My First Million is a HubSpot Original Podcast // Brought to you by HubSpot Media // Production by Arie Desormeaux // Editing by Ezra Bakker Trupiano

Knowledge Project: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Most accelerators fund ideas. Y Combinator funds founders—and transforms them. With a 1% acceptance rate and alumni behind 60% of the past decade’s unicorns, YC knows what separates the founders who break through from those who burn out. It's not the flashiest résumé or the boldest pitch but something President Garry Tan says is far rarer: earnestness. In this conversation, Garry reveals why this is the key to success, and how it can make or break a startup. We also dive into how AI is reshaping the whole landscape of venture capital and what the future might look like when everyone has intelligence on tap.  If you care about innovation, agency, or the future of work, don’t miss this episode.  Approximate timestamps: Subject to variation due to dynamically inserted ads. (00:02:39) The Success of Y Combinator (00:04:25) The Y Combinator Program (00:08:25) The Application Process (00:09:58) The Interview Process (00:16:16) The Challenge of Early Stage Investment (00:22:53) The Role of San Francisco in Innovation (00:28:32) The Ideal Founder (00:36:27) The Importance of Earnestness (00:42:17) The Changing Landscape of AI Companies (00:45:26) The Impact of Cloud Computing (00:50:11) Dysfunction with Silicon Valley (00:52:24) Forecast for the Tech Market (00:54:40) The Regulation of AI (00:55:56) The Need for Agency in Education (01:01:40) AI in Biotech and Manufacturing (01:07:24) The Issue of Data Access and The Legal Aspects of AI Outputs (01:13:34) The Role of Meta in AI Development (01:28:07) The Potential of AI in Decision Making (01:40:33) Defining AGI (01:42:03) The Use of AI and Prompting (01:47:09) AI Model Reasoning (01:49:48) The Competitive Advantage in AI (01:52:42) Investing in Big Tech Companies (01:55:47) The Role of Microsoft and Meta in AI (01:57:00) Learning from MrBeast: YouTube Channel Optimization (02:05:58) The Perception of Founders (02:08:23) The Reality of Startup Success Rates (02:09:34) The Impact of OpenAI (02:11:46) The Golden Age of Building Newsletter - The Brain Food newsletter delivers actionable insights and thoughtful ideas every Sunday. It takes 5 minutes to read, and it’s completely free. Learn more and sign up at fs.blog/newsletter Upgrade — If you want to hear my thoughts and reflections at the end of the episode, join our membership: ⁠⁠⁠⁠⁠⁠⁠fs.blog/membership⁠⁠ and get your own private feed. Watch on YouTube: @tkppodcast Learn more about your ad choices. Visit megaphone.fm/adchoices

Shawn Ryan Show: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Marat Gabidullin, born in Siberia and raised in Uzbekistan, served in Soviet airborne forces until 1994, then spent three years in prison for shooting a crime boss. After security work in Russia, he joined the Wagner Group in 2015, rose to lead a reconnaissance company, and was badly wounded near Palmyra in 2016. He later advised the ISIS Hunters Battalion and fought at Khasham, but quit Wagner in 2019, briefly ran a Redut detachment in Syria, and left disillusioned. Gabidullin’s 2022 memoir denounced Wagner and Russia’s invasion of Ukraine; he now lives in France. Journalist and researcher John Lechner reports from conflict zones and specializes in Russian PMCs. His book Death Is Our Business (Bloomsbury, 2025) charts the rise of Wagner, following earlier work such as Beginner’s Chechen and upcoming Circassian and Sango language texts. A former policy analyst for the U.S. Commission on International Religious Freedom and an emerging-markets banker at Deutsche Bank and Lazard, Lechner holds degrees from Harvard (Slavic Languages) and Georgetown (MSFS). Fluent in five languages and conversant in several others, he is a recognized expert on Russian foreign policy and has written for The Washington Post, The New York Times, The Atlantic, and Foreign Policy. He lives in Washington, DC. Shawn Ryan Show Sponsors: ⁠https://www.roka.com⁠ - USE CODE SRS https://www.americanfinancing.net/SRS NMLS 182334, nmlsconsumeraccess.org https://www.expressvpn.com/SRS https://www.shawnlikesgold.com https://www.hillsdale.edu/SRS https://www.shopify.com/SRS https://trueclassic.com/SRS https://www.ziprecruiter.com/SRS Guest Links: Marat Gabidullin FB - https://www.facebook.com/share/15TBVmf2mt/  Book - Moi, Marat, ex-commandant de l'armée Wagner - Les dessous de l'armée secrète de Poutine enfin révélé https://a.co/d/csNMjFH  Book - Ma vérité https://a.co/d/bLZYssf  John Lechner X - https://x.com/JohnLechner1 IG - https://www.instagram.com/johnalechner/ FB - https://www.facebook.com/john.lechner.5 Book - Death Is Our Business: Russian Mercenaries and the New Era of Private Warfare https://a.co/d/7rKXhnI Learn more about your ad choices. Visit podcastchoices.com/adchoices

Doctor's Farmacy with Mark Hyman, MD: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Many people struggle with mysterious symptoms like fatigue, brain fog, food sensitivities, and skin issues—only to be misdiagnosed or dismissed altogether. This conversation highlights how histamine intolerance and mast cell activation syndrome can be the hidden drivers behind a wide range of chronic conditions, and why they're often overlooked in conventional medicine. From the role of gut health, food triggers, and environmental toxins to deeper root causes like Lyme disease or mold exposure, it’s clear that personalized, Functional Medicine is key to uncovering real answers. Understanding the immune system’s role in histamine reactions—and how even “healthy” foods can be inflammatory for some—is a critical step toward healing. In this episode, I talk with Dr. Todd LePine, Dr. Elizabeth Boham, and Dr. Mark Pimentel about what histamine intolerance is, how it can be related to gut health, and why it’s important to address it. Dr. Todd LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders, and the neurobiology of mood and cognitive disorders. Dr. LePine enjoys skiing, kayaking, hiking, camping, and golfing in the beautiful Berkshires, and is a fitness enthusiast. Dr. Elizabeth Boham is Board Certified in Family Medicine from Albany Medical School, and she is an Institute for Functional Medicine Certified Practitioner and the Medical Director of The UltraWellness Center. Dr. Boham lectures on a variety of topics, including Women’s Health and Breast Cancer Prevention, insulin resistance, heart health, weight control and allergies. She is on the faculty for the Institute for Functional Medicine. Dr. Mark Pimentel is a Professor of Medicine and Gastroenterology through the Geffen School of Medicine and an Associate Professor of Medicine at Cedars-Sinai. Dr. Pimentel is also the Executive Director of the Medically Associated Science and Technology (MAST) program at Cedars-Sinai, an enterprise of physicians and researchers dedicated to the study of the gut microbiome in order to develop effective diagnostic tools and therapies to improve patient care.  Dr. Pimentel has over 150 publications in many high-profile journals, and he is the author of the book, The Microbiome Connection: Your Guide to IBS, SIBO, and low fermentation eating. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN10 to save 10%. Full-length episodes can be found here: Is Histamine Intolerance The Cause Of Your Mysterious Symptoms? What is Histamine Intolerance? Surprising Symptoms You Need to Know IBS: It’s Not In Your Head—Advances In Diagnosing And Treating, Bloating And Tummy Troubles

Conversations with Tyler: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Harvard economist Kenneth Rogoff approaches global finance with the same strategic foresight that made him a chess grandmaster. Author of the new book Our Dollar, Your Problem, Rogoff doesn't sugarcoat America's future: he foresees a significant inflation shock within a decade, far more severe than the post-COVID bout. When this second wave hits, he warns, "credibility's really going to be shot." In this conversation, Ken and Tyler tackle international economic dynamics, unresolved macro puzzles, the state of chess, and more, including whether trade deficits are truly unsustainable, why China's investment-heavy growth model has reached its limits, how currency depreciation neutralizes tariff effects, Pakistan’s IMF bailouts, whether more Latin American countries should dollarize, Japan's deceptively peaceful economic decline, Europe's coming fiscal reckoning, how the US will eventually confront its ballooning debt, the puzzling absence of a recession during our recent disinflation, the potential of phasing out large denomination currency notes, the future relevance of stablecoins, whether America should start a CBDC, Argentina's chances under Milei, who will be the next dominant player in chess, hanging out with Bobby Fischer, drawing out against Magnus Carlsen, and how to save classical chess from excessive computer preparation. Read a full transcript enhanced with helpful links, or watch the full video. Recorded April 2nd, 2025. Help keep the show ad free by donating today! Other ways to connect Follow us on X and Instagram Follow Tyler on X Follow Kenneth on X Sign up for our newsletter Join our Discord Email us: cowenconvos@mercatus.gmu.edu Learn more about Conversations with Tyler and other Mercatus Center podcasts here.

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"History 102" with WhatifAltHist's Rudyard Lynch and Erik Torenberg: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- In this episode of History 102, 'WhatIfAltHist' creator Rudyard Lynch and co-host Austin Padgett examine Native American genetic origins and cultural complexity, challenging popular narratives of "noble savages." They discuss surprising genetic links to Pacific Islanders and ancient Europeans, the sophisticated warfare and political structures of tribes like the Iroquois and Cherokee, and how European contact transformed indigenous societies through disease, technology, and shifting power dynamics. -- 📰 Be notified early when Turpentine's drops new publication: https://www.turpentine.co/exclusiveaccess -- SPONSOR: NETSUITE | SHOPIFY | ORACLE More than 40,000 businesses have already upgraded to NetSuite by Oracle, the #1 cloud financial system bringing accounting, financial management, inventory, HR, into ONE proven platform. If you're looking for an ERP platform, get a one-of-a-kind flexible financing program on NetSuite: https://netsuite.com/zen - Download your free CFO's guide to AI and machine learning. Shopify is the world's leading e-commerce platform, offering a market-leading checkout system Shoppay and exclusive AI apps. Nobody does selling better than Shopify. Get a $1 per month trial at https://shopify.com/momentofzen Oracle Cloud Infrastructure (OCI): Oracle's next-generation cloud platform delivers blazing-fast AI and ML performance with 50% less for compute and 80% less for outbound networking compared to other cloud providers. OCI powers industry leaders like Vodafone and Thomson Reuters with secure infrastructure and application development capabilities. New U.S. customers can get their cloud bill cut in half by switching to OCI before March 31, 2024 at https://oracle.com/cognitive -- FOLLOW ON X: @whatifalthist (Rudyard) @LudwigNverMises (Austin) @TurpentineMedia -- KEY HIGHLIGHTS OF THE DISCUSSION Learn more about your ad choices. Visit megaphone.fm/adchoices

Infinite Loops: Read the notes at at podcastnotes.org. Don't forget to subscribe for free to our newsletter, the top 10 ideas of the week, every Monday --------- Nathan Baschez is the cofounder and CEO of Lex, an AI word-processor. He also cofounded Every, was the first employee at Substack AND co-created Product Hunt. Suffice to say, Nathan knows a thing or two about building on the internet. He joins the show to discuss how AI is changing writing, why it’s time to rethink the article, the rise of solo founders and MUCH more. I hope you enjoy this conversation as much as I did. For the full transcript, episode takeaways, and bucketloads of other goodies designed to make you go, “Hmm, that’s interesting!”, check out our Substack. Important Links: Lex Twitter Substack LinkedIn Show Notes: Lex: Your Spotter In the Writing Gym Letting People Into Your Creative Process Collaboration-as-a-Service Creation Is Fundamentally About Choices What Will Become of the AI Holdouts? AI Is Like the Internet In 1995 Can AI Unfuck the Government? Blindspots While Working In Organizations Rethinking The ‘Article’ As A Medium Memes Are Dense Information Packets It’s Time for Solo Founders Why Learning About Cumulative Cultural Evolution Is Vital What’s Next for Lex? Writing As A Way To Design Thoughts Nathan As World Emperor Books Mentioned: A Swim in a Pond in the Rain: In Which Four Russians Give a Master Class on Writing, Reading, and Life; by George Saunders The WEIRDest People in the World: How the West Became Psychologically Peculiar and Particularly Prosperous; by Joseph Henrich The Secret of Our Success: How Culture Is Driving Human Evolution, Domesticating Our Species, and Making Us Smarter; by Joseph Henrich