Sleep Unplugged with Dr. Chris Winter

Chris Winter, MD
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Dec 8, 2025 • 41min

#181 - Sleep Aids and Dementia: All Manner of Pills

You probably saw the headlines out of California as they sent a jolt through the sleep world as well as social media: Do common sleep medications increase your risk of dementia? In this episode we will:Review what the UCSF study actually found — and what the headlines got wrongDetermine which medications are most often implicated (benzodiazepines vs Z-drugs vs trazodone)Take a deep dive into the three best studies on sleeping pills and dementia riskFind out why some large studies do show a connection… and others don’tLearn the real risks you should take seriously — even if dementia isn’t one of themThink about how doctors should actually practice prescribing sleep meds in older adultsProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Dec 1, 2025 • 36min

#180 - Top 10 Sleep Threat Power Rankings: Sleeping Eyes, You’re Missing (Out)

This week marks the 7th month we have put out the Top 10 Sleep Threats Power Rankings, but it's the first time we have devoted an entire episode to the list. this week, we have a special guest assessor, Dr. Jade Wu. In this episode we will:Find out what Jade thinks are the top threats to your sleepFocus on mental health as a sleep detractorLearn more about the concept of FOMO or "fear of missing out" and how research is indicating it is a real threat to the sleep of manyProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Nov 24, 2025 • 35min

#179 - The 4th Annual Holiday Sleep Gift Guide Extravaganza: The Perfect Gift

Fear not, the Sleep Unplugged podcast is once again here to solve your holiday shopping dilemmas with some of my favorite sleep product companies. In this episode, we will explore a host of sleep-themed gift ideas and product recommendations. In this episode, we will feature the following products:SideSleeperZ slip-proof sleep maskAuthenticity50 beddingBee Ulmo honeyBlueAir air purification systems (MiniRestful)Dagsmejan sleepwearHästens mattresses and sleep productsHoneydew Sleep pillowsLoftie alarm clocksMoonbrew drink mixNatrol Sleep & Restore supplementsOzlo sleep earbudsPath waterQuietOn noise cancelling sleep earbudsSleeping Dove comfortersSleep ProteinTruvaga vagal nerve stimulatorWeLove Creations earplugsZdenProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Nov 17, 2025 • 39min

#178 - Orexin Agonists Are Here: This Is The New Stuff

The orexin receptor agonists are coming. After years of managing narcolepsy with stimulants, sodium oxybate, and wake-promoting agents, we soon will have medications that target the root cause of the disorder: the loss of orexin signaling. These new drugs—developed by Takeda, Alkermes, and Centessa—aren’t just incremental improvements. They represent a genuine shift in how we understand and treat hypersomnolence disorders. In this episode, we will:Define what orexin is and why losing it destabilizes wakefulness, REM boundaries, muscle tone, and cognitionLearn how orexin agonists work—not as stimulants, but as replacement therapy for a missing neurotransmitterFind out why OX2R is the key receptor, and how selective agonists restore stable wakefulness, reduce cataplexy, and normalize attentionReview the available clinical data from the new wave of programs: oveporexton (Takeda), alixorexton (Alkermes), and ORX750 (Centessa)See what makes these drugs different from modafinil, amphetamines, solriamfetol, and oxybate therapiesLearn why Phase 1, Phase 2, and Phase 3 trials matter—with quick insights on how these drugs reached such strong resultsConsider safety and side effects, including what Hy’s Law means and why regulators watch liver signals so closelyLook ahead to what these medications may mean for NT1, NT2, IH, and other hypersomnolence disorders in the coming yearsSpeculate why this class represents one of the most exciting moments in modern sleep medicineProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Nov 10, 2025 • 38min

#177 - Sleep Fragmentation - Picking Up the Pieces

At the root of many sleep disorders of sleep fragmentation. It's a big part of sleep medicine that many people don't know much about. In this episode we will:Define sleep fragmentationContrast the differences between arousals from sleep and awakenings from sleepUnderstand why sleep fragmentation goes unnoticed by providers and patients alikeList some common causes of sleep fragmentationReview how sleep fragmentation appears in sleep dataTouch upon research about sleep fragmentation specifically and performanceProvide strategies for reducing sleep fragmentationProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Nov 3, 2025 • 37min

#176 - Media and Insomnia: It’s So Hard To Tell From Just A Magazine

The media can be a fantastic source of information about insomnia, or it can be a lens that distorts and confuses the issue. In this episode we will:Contrast to contemporary insomnia articles from popular mediaUnderstand the difference between causation and relationshipsLearn how the use to percentages can distort the scale of an effectRead how media frequently confuses "sleep deprivation" and "insomnia"Evaluate an example of how media can positively educate and help readers understand insomnia betterProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Oct 27, 2025 • 39min

#175 - World Series, Performance, and Sleep: Out of the Blue

For the first time in my career, two team for who I work will meet for the championship, this time it's the Los Angeles Dodgers (my 10th year with the club) and the Toronto Blue Jays (my 3rd year with the club). In this episode we will:Discuss my work in MLBTalk about how these two teams came to sleep medicine as a performance toolLearn how anybody or any organization could benefit from sleepProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Oct 20, 2025 • 37min

#174 - Hydration and Sleep: It's In The Water

Explore the surprising connection between hydration and sleep quality! Discover how dehydration can disrupt your sleep architecture and raise your heart rate. Learn strategies for optimal hydration, including the best times and types of fluids to consume. Delve into fascinating studies linking sleep duration with hydration levels. Plus, find out how cultures differ in their fluid intake and the importance of humidification for a better night's rest. Hydration might just be the secret to improving your sleep!
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Oct 13, 2025 • 22min

#173 - Sleep and Altitude: Only Look Up

Whether you’re skiing in Aspen, hiking Kilimanjaro, or just wondering why sleep feels so strange in the mountains, altitude messes with your rest in fascinating ways. In this episode we will:Explore the biology of what’s really happening in the brain and body when oxygen thins outFind out why your sleep becomes fragmented and restless, and what recent research reveals about the role of hypoxia, periodic breathing, and even oxidative stress in your slumber at altitudeShare new data on how altitude amplifies both insomnia and sleep apneaUnpack the science behind those sleepless nights at high elevationProvide practical, evidence-based strategies to make them better Produced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!
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Oct 6, 2025 • 29min

#172 - Sleep Hygiene is Not Insomnia Therapy: Save Me Tonight

We’ve all heard the sleep hygiene advice: turn off your screens, keep your room cool, avoid caffeine after lunch. While we can agree that these practices set the stage for better sleep, does engaging in them actually help those with sleep problems?  In this episode we will:Examine the intended role of sleep hygieneLook at what research tell us in terms of using sleep hygiene as a tool for insomnia treatmentDive into what it means for an insomnia therapy to workDifferentiate between actions geared at changing sleep behaviors and actions geared towards changing interpretations of sleep behaviorsProduced by: Maeve WinterMore Twitter: @drchriswinter IG: @drchriwinter Threads: @drchriswinter Bluesky: @drchriswinter The Sleep Solution and The Rested Child Thanks for listening and sleep well!

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