Dr. Jonathan Stea, a mental health expert and author, dives into the pitfalls of alternative medicine and the misinformation fueling its popularity. He discusses the psychological allure of pseudoscience and highlights the dangers of relying on unverified treatments. The conversation also explores cannabis's complex role in mental health, the troubling misuse of stimulants like Adderall, and the ethics of patient autonomy in treatment choices. Stea underscores the importance of evidence-based practices and the responsibility of mental health professionals in combating misinformation.

Nurse Blake, a leading voice in nursing advocacy, shares his insights on the profession's challenges. He highlights the emotional strain nursing inflicts on workers, emphasizing the need for humor to cope. The conversation dives into the evolving landscape of nursing, including non-traditional roles and the importance of mental health. Nurse Blake critiques media portrayals of nurses while promoting authentic representation. He also discusses the significance of camaraderie and laughter in enhancing patient care and addressing the ongoing issues within healthcare.

Renowned food scientist Marion Nestle discusses the food industry's influence on public health, unethical marketing practices targeting lower-income communities, and the impact of artificial sweeteners. They also explore the ethical dilemma of athlete sponsorships by soda companies and the meat industry's control over sustainability in dietary guidelines.

Dr. Mike Israetel discusses the dark side of steroids, the future of exercise pills, benefits of AI, and mistakes in deadlifting on the podcast. He also provides insights on starting a fitness journey, gaining muscles while staying lean, and differences between anabolic steroids and TRT.

Dr. Jack Turban discusses transgender healthcare, gender dysphoria treatment, and the importance of affirming gender identities. Topics include puberty blockers for children, challenges in Europe vs. USA healthcare, transgender athletes, and the debate on bathroom laws.

Dr. Jonathan Haidt discusses the harms of social media, focusing on the impact on Generation Z and contrasting it with previous generations. Topics include the influence of smartphones on adolescent socialization, the evolution of social media's impact on society, and the negative effects on mental health, especially in girls. The podcast also explores the challenges faced by different age groups and the ongoing scientific debates surrounding social media.

YouTube sensation Tommy Innit joins Doctor Mike to discuss his stand-up comedy, therapy sessions, hospitalization for water-related issues, and a hilarious account of his unexpected testicle surgery. The conversation covers anxiety, internet fame, and seeking advice from YouTubers like Logan Paul in critical situations.

The podcast discusses the risks of YouTube medicine, mindfulness, Ayurvedic medical tests, popularity of Ayurveda, weaknesses of Ayurveda, advantages of Ayurveda, and the existence of 'thought', offering insights on mental health stigma, Enlightenment, and placebo effects.

Entrepreneur Bryan Johnson discusses his pursuit of extending human life through technology in 'The Checkup with Doctor Mike'. Topics include using AI for immortality, tracking health, dangers of overpopulation, plasma transfusions, sleep tracking, and the harms of extreme health optimization.

Dr. Paul Offit discusses the truth behind COVID-19, including booster shots, mistakes of Trump and Biden administrations, misinformation, social media debates, and the lab leak theory. He emphasizes the importance of public trust, accurate reporting, and being prepared for future disasters.