The MIT Press Podcast

Biomedical research using various animal species and in vitro cellular systems has resulted in both major successes and translational failure. In Model Systems in Biology: History, Philosophy, and Practical Concerns (MIT Press, 2022), comparative neurobiologist Georg Striedter examines how biomedical researchers have used animal species and in vitro cellular systems to understand and develop treatments for human diseases ranging from cancer and polio to Alzheimer’s disease and schizophrenia. Although there have been some major successes, much of this “translational” research on model systems has failed to generalize to humans. Striedter explores the history of such research, focusing on the models used and considering the question of model selection from a variety of perspectives—the philosophical, the historical, and that of practicing biologists.Striedter reviews some philosophical concepts and ethical issues, including concerns over animal suffering and the compromises that result. He traces the history of the most widely used animal and in vitro models, describing how they compete with one another in a changing ecosystem of models. He examines how therapies for bacterial and viral infections, cancer, cardiovascular diseases, and neurological disorders have been developed using animal and cell culture models—and how research into these diseases has both taken advantage of and been hindered by model system differences. Finally, Striedter argues for a “big tent” biology, in which a diverse set of models and research strategies can coexist productively.Rachel Pagones is an acupuncturist, educator, and author based in Cambridge, England. Her book, Acupuncture as Revolution: Suffering, Liberation, and Love (Brevis Press) was published in 2021.

How should we form new beliefs? In particular, what inferential strategies are epistemically justified for forming new beliefs? Nowadays the dominant theory is Bayesianism, whereby we ought to reason in accordance with Bayes’s rule based in the axioms of probability theory. In The Art of Abduction (The MIT Press, 2022), Igor Douven defends the alternative Inference to the Best Explanation (abduction), in which explanatory considerations play an essential role in determining what we should come to believe. Douven, who is research professor at CNRS, lays out and responds to traditional arguments against abduction and shows how abduction can be a better reasoning strategy than Bayesianism in many contexts. He also considers how abduction fares in the context of social epistemology, and provides an answer to the traditional problem of skepticism about the existence of an external world.Carrie Figdor is professor of philosophy at the University of Iowa.

This is part two of a two part interview.Mark Solovey’s ‘Social Science for What?’ is essential reading for anyone in either the history of science policy or the history of the social sciences in the United States. The book is not, as the subtitle might imply, merely an institutional history of the social sciences at the U.S. National Science Foundation (NSF). Rather, Solovey’s follow-up to his 2013 book, ‘Shaky Foundations: The Politics-Patronage-Social Science Nexus in Cold War America’, is a commanding explanation of certain characteristics of academic social science as commonly practiced in the United States in the second half of the twentieth century.— Audra J. Wolfe, PhD. history and sociology of science, in ISIS Vol. 113, No. 2, June 2022In our first episode, Professor Solovey shared some of the political and legislative history establishing the National Science Foundation; heated controversy over the social sciences that undermined the effort to include them in the initial legislation for the new science agency; how they nevertheless became included on a small and cautious basis grounded in a scientistic strategy; and some of the landmark developments, controversies, and interesting individuals involved from roughly the mid-1940s to the late 1960s. This included Senator Harris's remarkable legislative proposal in the mid-to-late 1960s to establish a separate national social science foundation.This second part of the interview opens with the late 1960s' controversy over Project Camelot and draws on Mark’s 2001 journal article in the Social Studies of Science, titled ‘Project Camelot and the 1960s Epistemological Revolution: Rethinking the Politics–Patronage–Social Science Nexus’ - which remains the professor’s most often cited scholarly article. We then move up through the dark days of the Reagan years, along the way discussing key figures, from David Stockman to Talcott Parsons, Clifford Geertz, Thomas Kuhn, Milton Friedman, and Richard Atkinson, the emergence and impact of the Consortium of Social Science Associations (COSSA), alternatives to the scientistic strategy, and persistent challenges faced by the social sciences at the levels of institutional representation, leadership and funding constraints relative to the natural sciences - all of which continue to the present day.We end with Professor Solovey’s call for reviving the idea of a new federal agency for the social sciences, a National Social Science Foundation, as first introduced by Senator Harris of Oklahoma, and finally, with some book recommendations.An open access edition of Social Science for What?: Battles over Public Funding for the "Other Sciences' at the National Science Foundation (MIT Press, 2020) was made possible by generous funding from the MIT Libraries.Mark Solovey is professor at the University of Toronto’s Institute for the History and Philosophy of Science and Technology. His research focuses on the development of the social sciences in the United States, and especially the controversies regarding the scientific identity of the social sciences, private and public funding for them, and public policy implications of social science expertise. He has written and co-edited a number of books related to the Cold War and social science history.Keith Krueger lectures in the SILC Business School at Shanghai University.

For The Real World of College: What Higher Education Is and What It Can Be (MIT Press, 2022), Wendy Fischman and Howard Gardner analyzed in-depth interviews with more than 2,000 students, alumni, faculty, administrators, parents, trustees, and others, which were conducted at ten institutions ranging from highly selective liberal arts colleges to less-selective state schools. What they found challenged characterizations in the media: students are not preoccupied by political correctness, free speech, or even the cost of college. They are most concerned about their GPA and their resumes; they see jobs and earning potential as more important than learning. Many say they face mental health challenges, fear that they don't belong, and feel a deep sense of alienation. Given this daily reality for students, has higher education lost its way? Fischman and Gardner contend that US universities and colleges must focus sharply on their core educational mission.Fischman and Gardner, both recognized authorities on education and learning, argue that higher education in the United States has lost sight of its principal reason for existing: not vocational training, not the provision of campus amenities, but to increase what Fischman and Gardner call "higher education capital"--to help students think well and broadly, express themselves clearly, explore new areas, and be open to possible transformations. Fischman and Gardner offer cogent recommendations for how every college can become a community of learners who are open to change as thinkers, citizens, and human beings.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland.

Graduate students and newly-minted economists often find that while their time in graduate school taught them a lot about great research of the past and the methods needed to do their own research, they didn't learn that much about the other aspects of the job. How do you submit a paper to a journal? How do you respond to reviewer comments? How do you write referee reports for other people? How do you present you findings in clear and compelling way, whether in a paper or in a talk? Academic advisors and other mentors can help fill the gap, but may not even realize they need to communicate things that they know implicitly. The existence of this hidden curriculum also perpetuates the insider bias and lack of diversity in economics, making it harder for the best ideas to rise to the top.Marc Bellemare's new book Doing Economics: What You Should Have Learned in Grad School--But Didn't (MIT, 2022), helps fill the gap. This book is essential reading for economists and other quantitative social scientists trying to succeed in academia and adjacent fields. Graduate students and junior faculty should read it cover to cover. Senior faculty can also benefit from having a copy around to help make sure their own advice is comprehensive and up-to-date.Author Marc Bellemare is the Distinguished McKnight University Professor, Distinguished University Teaching Professor, and Northrop Professor in the Department of Applied Economics at the University of Minnesota, where he also directs the Center for International Food and Agricultural Policy. He is also currently a co-editor of the American Journal of Agricultural Economics. He also blogs regularly and can be found on Twitter.Host Peter Lorentzen is an Associate Professor in the Department of Economics at the University of San Francisco, where he leads a new Master's program in Applied Economics focused on the digital economy. His own research focus is the political economy of governance in China.

Erika Balsom and Hila Peleg's edited volume Feminist Worldmaking and the Moving Image (MIT Press, 2022) offers intersectional, intergenerational, and international perspectives on nonfiction film- and videomaking by and about women, examining practices that range from activist documentaries to avant-garde experiments. Concentrating primarily on the period between the 1970s and 1990s, the contributions revisit major figures, contexts, and debates across a polycentric, global geography. They explore how the moving image has been a crucial terrain of feminist struggle--a way of not only picturing the world but remaking it.The contributors consider key decolonial filmmakers, including Trinh T. Minh-ha and Sarah Maldoror; explore collectively produced films with ties to women's liberation movements in different countries; and investigate the cinematic expressions of tensions and alliances between feminism and anti-imperialist struggles. They grapple with the need for a broader more inclusive definition of the term "feminism"; meditate on the figure of the grandmother; reflect on realist aesthetics; and ask what a feminist film historiography might look like.The book, generously illustrated with film stills and other images, many in color, offers ten original texts, two conversations, and eight short essays composed in response to historical texts written by filmmakers. The historical texts, half of which are published in English for the first time, appear alongside the essays.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland.

In Formulations: Architecture, Mathematics, Culture (MIT Press, 2022), Andrew Witt examines the visual, methodological, and cultural intersections between architecture and mathematics. The linkages Witt explores involve not the mystic transcendence of numbers invoked throughout architectural history, but rather architecture’s encounters with a range of calculational systems—techniques that architects inventively retooled for design. Witt offers a catalog of mid-twentieth-century practices of mathematical drawing and calculation in design that preceded and anticipated digitization as well as an account of the formal compendia that became a cultural currency shared between modern mathematicians and modern architects.Witt presents a series of extensively illustrated “biographies of method”—episodes that chart the myriad ways in which mathematics, particularly the mathematical notion of modeling and drawing, was spliced into the creative practice of design. These include early drawing machines that mechanized curvature; the incorporation of geometric maquettes—“theorems made flesh”—into the toolbox of design; the virtualization of buildings and landscapes through surveyed triangulation and photogrammetry; formal and functional topology; stereoscopic drawing; the economic implications of cubic matrices; and a strange synthesis of the technological, mineral, and biological: crystallographic design.Trained in both architecture and mathematics, Witt uses mathematics as a lens through which to understand the relationship between architecture and a much broader set of sciences and visual techniques. Through an intercultural exchange with other disciplines, he argues, architecture adapted not only the shapes and surfaces of mathematics but also its values and epistemic ideals.Bryan Toepfer, AIA, NCARB, CAPM is the Principal Architect for TOEPFER Architecture, PLLC, an Architecture firm specializing in Residential Architecture and Virtual Reality. He has authored two books, “Contractors CANNOT Build Your House,” and “Six Months Now, ARCHITECT for Life.” He is an Assistant Professor at Alfred State College and has served as the Director of Government Affairs and as the Director of Education for the AIA Rochester Board of Directors. Always eager to help anyone understand the world of Architecture, he hosts the New Books Network – Architecture podcast, is an NCARB Licensing Advisor and helps coach candidates taking the Architectural Registration Exam. btoepfer@toepferarchitecture

We are not what we think we are. Our self-image as natural individuated subjects is determined behind our backs: historically by political forces, cognitively by the language we use, and neurologically by sub-personal mechanisms, as revealed by scientific and philosophical analyses.Under contemporary capitalism, as the gap between this self-image and reality becomes an ever greater source of social and mental distress, these theoretical insights are potential dynamite. Shifting his explorations from the sonic to the social, amplifying alienation and playing with psychic noise, artist and performer Mattin finally lights the fuse.The noise is here to stay. Alienation is a constitutive part of subjectivity and an enabling condition for exploring social dissonance—the territory upon which we already find ourselves, the condition we inhabit today.Mattin speaks (and sings) to Pierre d’Alancaisez about his performance score Social Dissonance, in which the audience is the instrument and the legacy of the Marxist theory of alienation.Mattin is an artist, musician and theorist working conceptually with noise and improvisation. Through his practice and writing, he explores performative forms of estrangement as a way to deal with structural alienation. Mattin has exhibited and toured worldwide.He has performed in festivals such as Performa and Club Transmediale and lectured in institutions such as Dutch Art Institute, Cal Arts, Bard, and Goldsmiths. Mattin is part of the bands Billy Bao and Regler and has over 100 releases on different labels worldwide. He co-hosts the podcast Social Discipline. Mattin took part in 2017 in documenta14 in Athens and Kassel. Information on the Social Dissonance concert at Documenta 14 A video recording of one of the performances Social Discipline podcast Pierre d’Alancaisez is a contemporary art curator, cultural strategist, researcher. Sometime scientist, financial services professional.

An argument that social, political, and economic systems maintain power by discarding certain people, places, and things. Discard studies is an emerging field that looks at waste and wasting broadly construed. Rather than focusing on waste and trash as the primary objects of study, discard studies looks at wider systems of waste and wasting to explore how some materials, practices, regions, and people are valued or devalued, becoming dominant or disposable. In Discard Studies: Wasting, Systems, and Power (MIT Press, 2022), Max Liboiron and Josh Lepawsky argue that social, political, and economic systems maintain power by discarding certain people, places, and things. They show how the theories and methods of discard studies can be applied in a variety of cases, many of which do not involve waste, trash, or pollution. Liboiron and Lepawsky consider the partiality of knowledge and offer a theory of scale, exploring the myth that most waste is municipal solid waste produced by consumers; discuss peripheries, centers, and power, using content moderation as an example of how dominant systems find ways to discard; and use theories of difference to show that universalism, stereotypes, and inclusion all have politics of discard and even purification—as exemplified in “inclusive” efforts to broaden the Black Lives Matter movement. Finally, they develop a theory of change by considering “wasting well,” outlining techniques, methods, and propositions for a justice-oriented discard studies that keeps power in view.

Howard Gardner's Frames of Mind was that rare publishing phenomenon--a mind-changer. Widely read by the general public as well as by educators, this influential book laid out Gardner's theory of multiple intelligences. It debunked the primacy of the IQ test and inspired new approaches to education; entire curricula, schools, museums, and parents' guides were dedicated to the nurturing of the several intelligences. In his new book, A Synthesizing Mind: A Memoir from the Creator of Multiple Intelligences Theory (MIT Press, 2022), Gardner reflects on his intellectual development and his groundbreaking work, tracing his evolution from bookish child to eager college student to disengaged graduate student to Harvard professor.Galina Limorenko is a doctoral candidate in Neuroscience with a focus on biochemistry and molecular biology of neurodegenerative diseases at EPFL in Switzerland.